LDHA - Ldha lactate dehydrogenase A Gene

Also Known as CDK1; Ldh1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24533

Summary

Enables several functions, including L-lactate dehydrogenase activity; NAD binding activity; and identical protein binding activity. Involved in several processes, including response to cAMP; response to estrogen; and response to glucose. Predicted to be located in cytosol and sperm fibrous sheath. Biomarker of hyperglycemia. Orthologous to human LDHA (Lactate Dehydrogenase A). [provided by Alliance of Genome Resources, Apr 2022]

LDHA Products (1)

mRNA Protein Name
NM_017025.2 NP_058721.1 L-lactate dehydrogenase A chain

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables L-lactate dehydrogenase activity IDA
IDA: Inferred from direct assay
17447164 RGD
enables NAD binding IDA
IDA: Inferred from direct assay
17447164 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
7138505 RGD
enables kinase binding IPI
IPI: Inferred from physical interaction
17572440 RGD
enables lactate dehydrogenase activity IDA
IDA: Inferred from direct assay
6849973 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
7138505 RGD
Biological Process GO Annotation Evidence References Source
involved in NAD metabolic process IDA
IDA: Inferred from direct assay
17447164 RGD
involved in lactate metabolic process IDA
IDA: Inferred from direct assay
6849973 RGD
involved in liver development IDA
IDA: Inferred from direct assay
6849973 RGD
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
9465046 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
6300127 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
17010207 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
11457846 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
16154111 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
12678657 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
15110778 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
7758843 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11176097 RGD
involved in skeletal muscle tissue development IDA
IDA: Inferred from direct assay
6849973 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

L-lactate dehydrogenase A chain

  • LDH muscle subunit

  • LDH-A

  • LDH-M

Recombinant LDHA Proteins

Cat. No. Product Name Accession Purity
HY-P73271 LDHA Protein, Rat (His) P04642 (M1-F332) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100742A (R)-GNE-140 Inhibitor 99.77% Unkown
HY-100742 GNE-140 racemate Inhibitor 99.25% Unkown
HY-100742B (S)-GNE-140 Inhibitor 99.30% Unkown
HY-N4185 Licoflavone A Inhibitor 99.95% Unkown
HY-124113 4'-Bromo-resveratrol 99.94% Unkown
HY-118241 GNE-140 Inhibitor 98.43% Unkown
HY-183858 NCATS-SM1440 Inhibitor / Unkown
HY-16964 LDHA-IN-1 Inhibitor / Unkown
HY-175562 LDH-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens LDHA NCBI NCBI:3939