LDHA - lactate dehydrogenase A Gene

Also Known as LDHM; GSD11; PIG19; HEL-S-133P

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3939

About LDHA

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,394,563-18,408,425 (from NCBI)

This gene has 25 transcripts (splice variants), 1 gene allele, 297 orthologues, 5 paralogues and is associated with 2 phenotypes. Ubiquitous expression in small intestine (RPKM 177.1), liver (RPKM 154.8) and 25 other tissues.

Summary

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the Lactate Dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]

LDHA Products (5)

mRNA	Protein	Name
NM_001135239.2	NP_001128711.1	L-lactate dehydrogenase A chain isoform 2
NM_001165414.2	NP_001158886.1	L-lactate dehydrogenase A chain isoform 3
NM_001165415.2	NP_001158887.1	L-lactate dehydrogenase A chain isoform 4
NM_001165416.2	NP_001158888.1	L-lactate dehydrogenase A chain isoform 5
NM_005566.4	NP_005557.1	L-lactate dehydrogenase A chain isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables L-lactate dehydrogenase activity	IMP IMP: Inferred from mutant phenotype	34381247	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in lactate metabolic process	IDA IDA: Inferred from direct assay	24816116	GOA
involved in pyruvate metabolic process	IDA IDA: Inferred from direct assay	24816116	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of oxidoreductase complex	IPI IPI: Inferred from physical interaction	24816116	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LDHA Protein Structure

Ldh_1_N

Ldh_1_C

0
100
200
300
332 a.a.

Protein Preferred Names	Protein Names
L-lactate dehydrogenase A chain	LDH muscle subunit

LDHA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LDHA	P00338	LDHC	Homo sapiens	P07864	Anti Tag CoIP	35271311
Intra	LDHA	P00338	LDHC	Homo sapiens	P07864	Anti Tag CoIP	28514442
Intra	LDHA	P00338	LDHC	Homo sapiens	P07864	Anti Tag CoIP	33961781
Intra	LDHA	P00338	HSPA8	Homo sapiens	P11142	Anti Tag CoIP	23523103
Intra	LDHA	P00338	HSPA8	Homo sapiens	P11142	Anti Bait CoIP	23523103
Intra	LDHA	P00338	HSPA8	Homo sapiens	P11142	Pull Down	23523103
Intra	LDHA	P00338	LDHB	Homo sapiens	P07195	Y2H Array	31515488
Intra	LDHA	P00338	LDHB	Homo sapiens	P07195	Y2H	21988832
Intra	LDHA	P00338	LDHB	Homo sapiens	P07195	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LDHA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70225	LDHA Protein, Human (His)	P00338-1 (M1-F332)	≥ 95%, as determined by reducing SDS-PAGE.

LDHA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80422	Lactate Dehydrogenase Antibody (YA316)	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse
HY-P80738	Lactate Dehydrogenase A Antibody (YA317)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat
HY-P80738A	Lactate Dehydrogenase A Antibody (YA317)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat
HY-P80994	Lactate Dehydrogenase A Antibody (YA3482)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P80994A	Lactate Dehydrogenase A Antibody (YA3482)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P86602	Lactate Dehydrogenase Antibody (YA6294)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86628	Lactate Dehydrogenase Isoenzyme V Antibody (YA6320)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Fanconi-Bickel Syndrome	Glycogen Storage Disease Xi Lactate Dehydrogenase A Deficiency Hepatorenal Glycogenosis With Renal Fanconi Syndrome Hepatic Glycogenosis With Amino Aciduria And Glucosuria Fanconi Syndrome With Intestinal Malabsorption And Galactose Intolerance Pseudo-Phlorizin Diabetes Glycogen Storage Disease Due To Lactate Dehydrogenase M-Subunit Deficiency FBS Hepatic Glycogenosis With Fanconi Nephropathy GSD11 Gsd Xi Glycogen Storage Disease Due To Glut2 Deficiency Glycogenosis Fanconi Type Lactate Dehydrogenase Deficiency Type A Glycogenosis, Fanconi Type Fanconi Bickel Syndrome Glut2 Deficiency Gsd Due To Glut2 Deficiency Glycogenosis Due To Glut2 Deficiency Gsd Due To Lactate Dehydrogenase M-Subunit Deficiency Glycogenosis Due To Lactate Dehydrogenase M-Subunit Deficiency Ldh-M Subunit Deficiency Glycogen Storage Disease 11 Storage Disease, Glycogen, Type Xi Glycogenosis With Glucoaminophosphaturia
Myoglobinuria
Leiomyomatosis
Hyperinsulinemic Hypoglycemia, Familial, 7	HHF7 Exercise-Induced Hyperinsulinemic Hypoglycemia Exercise-Induced Hyperinsulinism Familial Hyperinsulinemic Hypoglycemia 7 Eihi Hyperinsulinism Due To Monocarboxylate Transporter 1 Deficiency Hyperinsulinism Due To Slc16a1 Deficiency Hyperinsulinemic Hypoglycemia, Exercise-Induced Exercise Induced Hyperinsulinemic Hypoglycemia Hyperinsulinemic Hypoglycemia Exercise-Induced Hyperinsulinemic Hypoglycemia Familial 7
Glycogen Storage Disease	Glycogenosis Glycogenoses Gsd Storage Disease, Glycogen Gsd - [Glycogen Storage Disease] Glycogen Thesaurismosis Diffuse Glycogenosis Generalised Glycogen Storage Disease Generalised Glycogenosis Generalised Glycogen Storage Disease Of Infants Glycogen Synthase Deficiency
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Retinitis Pigmentosa-Deafness Syndrome	Retinitis Pigmentosa 8, Formerly Rp8, Formerly Retinitis Pigmentosa 21, Formerly Rp21, Formerly Usher Syndrome
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Intrahepatic Gall Duct Cancer	Malignant Neoplasm Of Intrahepatic Bile Ducts Malignant Neoplasm Of Intrahepatic Gall Duct Ca Intrahepatic Bile Ducts Malignant Neoplasm Of Intrahepatic Biliary Passages Intrahepatic Bile Duct Carcinoma
Alzheimer Disease 13	AD13 Alzheimer Disease-13 Alzheimer'S Disease 13 Alzheimer'S Disease 13, Late Onset
Esophagus Carcinoma In Situ	Carcinoma In Situ Of Esophagus Carcinoma In Situ Of Oesophagus Oesophagus Carcinoma In Situ Severe Esophageal Dysplasia Stage 0 Carcinoma Of The Esophagus Stage 0 Carcinoma Of The Oesophagus Severe Oesophageal Dysplasia
Stress Polycythemia	Gaisbock'S Syndrome Polycythemia, Emotional Pseudopolycythaemia Gaisboeck'S Syndrome Pseudopolycythemia Gaisbock Syndrome Stress Erythrocytosis Pseudo-Polycythemia Relative Erythrocytosis
Liver Carcinoma In Situ	Carcinoma In Situ Of Liver And Biliary System Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Amyotrophic Lateral Sclerosis 3	ALS3 Amyotrophic Lateral Sclerosis Type 3
Parkinson Disease 17	PARK17 Parkinson'S Disease 17 Autosomal Dominant Parkinson Disease 17 Parkinson Disease, Type 17
Combined Oxidative Phosphorylation Deficiency 33	COXPD33
Prolapse Of Urethra	Urethrocele
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100742A	(R)-GNE-140	Inhibitor	99.77%	Unkown
HY-100742	GNE-140 racemate	Inhibitor	99.25%	Unkown
HY-100742B	(S)-GNE-140	Inhibitor	99.30%	Unkown
HY-N4185	Licoflavone A	Inhibitor	99.95%	Unkown
HY-124113	4'-Bromo-resveratrol		99.94%	Unkown
HY-118241	GNE-140	Inhibitor	98.43%	Unkown
HY-183858	NCATS-SM1440	Inhibitor	/	Unkown
HY-16964	LDHA-IN-1	Inhibitor	/	Unkown
HY-175562	LDH-IN-4	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LDHA	RGD	RGD:2996
Felis catus	LDHA	VGNC	VGNC:81201
Mus musculus	LDHA	MGD	MGI:96759
Others	LDHA	NCBI