LDHC - lactate dehydrogenase C Gene

Also Known as CT32; LDH3; LDHX

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3948

About LDHC

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,412,318-18,452,063 (from NCBI)

This gene has 10 transcripts (splice variants), 98 orthologues and 5 paralogues. Restricted expression toward testis (RPKM 186.5).

Summary

Lactate Dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the Lactate Dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008]

LDHC Products (2)

mRNA Protein Name
NM_002301.5 NP_002292.1 L-lactate dehydrogenase C chain
NM_017448.5 NP_059144.1 L-lactate dehydrogenase C chain

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LDHC Protein Structure

Ldh_1_N

Ldh_1_N: lactate/malate dehydrogenase, NAD binding domain (21 - 160)

Ldh_1_C

Ldh_1_C: lactate/malate dehydrogenase, alpha/beta C-terminal domain (164 - 326)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
Protein Preferred Names Protein Names

L-lactate dehydrogenase C chain

  • LDH testis subunit

LDHC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LDHC P07864 LDHB Homo sapiens P07195
Anti Tag CoIP
33961781
Intra
LDHC P07864 LDHA Homo sapiens P00338
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

LDHC Antibodies

Cat. No. Product Name Application Reactivity
HY-P80739 Lactate Dehydrogenase C Antibody (YA315) WB Human
HY-P80739A Lactate Dehydrogenase C Antibody (YA315)(PBS only) WB Human

Related Diseases

Diseases Alias
Varicocele

  • Scrotal Varices

  • Varicoceles

  • Varicocele Of Scrotum

  • Scrotal Varicocele
Korean Hemorrhagic Fever

  • Hemorrhagic Fever With Renal Syndrome
Nuclear Senile Cataract

  • Senile Nuclear Cataract

  • Senile Nuclear Sclerosis
Phototoxic Dermatitis

  • Dermatitis, Phototoxic

  • Photosensitisation Reaction

  • Photosensitive Dermatitis

  • Photosensitiveness
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100742A (R)-GNE-140 Inhibitor 99.77% Unkown
HY-RS07573 LDHC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-100742AR (R)-GNE-140 (Standard) Inhibitor / Unkown
HY-RS21363 Ldhc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27882 Ldhc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LDHC RGD RGD:69366
Bos taurus LDHC VGNC VGNC:56270
Mus musculus LDHC MGD MGI:96764
Felis catus LDHC VGNC VGNC:82036
Macaca mulatta LDHC VGNC VGNC:74247
Canis familiaris LDHC VGNC VGNC:52264
Others LDHC NCBI