2. Gene
  3. Vdr - vitamin D receptor Gene

Vdr - vitamin D receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Nr1i1

Gene ID: 24873 | Gene type: protein coding

About Vdr

Primary_assembly 7: 128,987,981-129,037,677 reverse strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 462 orthologues, 19 paralogues and is associated with 109 phenotypes. Biased expression in Kidney (RPKM 182.4), Lung (RPKM 16.2) and 3 other tissues.

Summary

Enables calcitriol binding activity; nuclear receptor activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of bone trabecula formation; and positive regulation of parathyroid hormone secretion. Located in several cellular components, including T-tubule; chromatin; and nuclear lumen. Colocalizes with caveola. Used to study vitamin D-dependent rickets type 2A. Biomarker of secondary hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); lipid storage disease (multiple); melanoma (multiple); and tuberculosis (multiple). Orthologous to human VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Apr 2022]

Vdr Products(1)

mRNA Protein Name
NM_017058.2 NP_058754.2 vitamin D3 receptor

Vdr Protein Structure

NR_DBD_VDR

NR_DBD_VDR: cd06955 (15 - 121)

NR_LBD_VDR

NR_LBD_VDR: cd06933 (123 - 421)

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  • 423 a.a.
Protein Preferred Names Protein Names

vitamin D3 receptor

1,25-dihydroxyvitamin D3 receptor

nuclear receptor subfamily 1 group I member 1

vitamin D (1,25- dihydroxyvitamin D3) receptor

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10002 Calcitriol Agonist 99.94% Unkown
HY-32351 Calcifediol 99.94% Unkown
HY-10003 Alfacalcidol Activator 99.93% Unkown
HY-32339 Maxacalcitol Activator 99.71% Unkown
HY-32351A Calcifediol monohydrate 99.89% Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-32344 Inecalcitol / Phase 2
Pre-clinical Phase
Bioactive Molecules (34)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147337 MeTC7 Antagonist 98.52% Unkown
HY-12398 TEI-9647 Agonist / Unkown
HY-12407 ZK168281 Antagonist 98.43% Unkown
HY-76814 Calcitriol-d6 Activator 99.06% Unkown
HY-103053 PS121912 Inhibitor ≥95.0% Unkown
HY-12398A TEI-9648 Inhibitor 99.30% Unkown
HY-12397 ZK159222 Antagonist 98.59% Unkown
HY-13332 Calcifediol-d6 Activator 98.91% Unkown
HY-15332 Alfacalcidol-d6 Activator ≥98.0% Unkown
HY-13294 Impurity C of Alfacalcidol Activator 99.81% Unkown
HY-32351S Calcifediol-d3 99.06% Unkown
HY-10002A (1S)-Calcitriol 98.31% Unkown
HY-15329 Maxacalcitol-d6 Activator 99.63% Unkown
HY-13292 Impurity B of Calcitriol Activator 98.04% Unkown
HY-13293 Impurity C of Calcitriol Activator 99.84% Unkown
HY-131961 Triciferol 98.61% Unkown
HY-15265 Impurity F of Calcipotriol Activator 99.40% Unkown
HY-15266 24R-Calcipotriol Activator / Unkown
HY-75035 Calcipotriol Impurity C Activator 99.20% Unkown
HY-75041 Calcitriol Impurities A Activator 99.78% Unkown
HY-77274 Calcitriol Impurities D Activator 95.18% Unkown
HY-15264 MC 1046 Activator 91.48% Unkown
HY-114310 VDR agonist 1 / Unkown
HY-10002S1 Calcitriol-d3 / Unkown
HY-10003S Alfacalcidol-d7 Activator / Unkown
HY-149899 VDR agonist 2 Agonist / Unkown
HY-32351AS Calcifediol-d6 monohydrate / Unkown
HY-32351AS1 Calcifediol-13C5 monohydrate / Unkown
HY-RS15632 VDR Human Pre-designed siRNA Set A / Unkown
HY-RS15633 Vdr Mouse Pre-designed siRNA Set A / Unkown
HY-RS15634 Vdr Rat Pre-designed siRNA Set A / Unkown
HY-10002S Calcitriol-13C3 Inhibitor ≥97.0% Unkown
HY-107218 11-Hydroxysugiol Modulator / Unkown
HY-32345 Elocalcitol Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vdr NCBI NCBI:7421
Mus musculus Vdr NCBI NCBI:22337