Sirpa - signal-regulatory protein alpha Gene

Also Known as Bit; Ptpns1; SHPS-1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25528

Summary

Enables GTPase regulator activity; enzyme binding activity; and protein binding activity involved in heterotypic cell-cell adhesion. Involved in several processes, including cellular response to cytokine stimulus; monocyte extravasation; and regulation of cytokine production. Located in cell surface. Orthologous to several human genes including SIRPA (signal regulatory protein alpha). [provided by Alliance of Genome Resources, Apr 2022]

Sirpa Products (1)

mRNA	Protein	Name
NM_013016.3	NP_037148.3	tyrosine-protein phosphatase non-receptor type substrate 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase regulator activity	IMP IMP: Inferred from mutant phenotype	16055727	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8810330	RGD
enables protein binding involved in heterotypic cell-cell adhesion	IPI IPI: Inferred from physical interaction	16055727	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	16055727	RGD
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	16055727	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration	IDA IDA: Inferred from direct assay	12023387	RGD
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	16055727	RGD
involved in cellular response to interleukin-1	IMP IMP: Inferred from mutant phenotype	12023387	RGD
involved in cellular response to type II interferon	IMP IMP: Inferred from mutant phenotype	12023387	RGD
involved in monocyte extravasation	IMP IMP: Inferred from mutant phenotype	12023387	RGD
involved in negative regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	21401967	RGD
involved in regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	16055727	RGD
involved in regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	16055727	RGD
involved in regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	16055727	RGD
involved in regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16055727	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	21401967	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tyrosine-protein phosphatase non-receptor type substrate 1	Brain immunoglobulin like protein with tyrosine - based activation motifs CD172 antigen-like family member A Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1) SHP substrate 1 brain Ig-like molecule with tyrosine-based activ

Recombinant Sirpa Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76072	SIRP alpha/CD172a Protein, Rat (HEK293, Fc)	BAA20368.1 (K32-N373)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76073	SIRP alpha/CD172a Protein, Rat (HEK293, His)	P97710 (K32-N373)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991693	Ipsoprubart	Inhibitor	97%	Phase 3
HY-P991016	Peluntamig		99.9%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12932	SIRPA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17207	Sirpa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23659	Sirpa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990555	BI-765063	Inhibitor	97.89%	Unkown
HY-P990723	Timdarpacept	Inhibitor	99.95%	Unkown
HY-P992346	DS-1103a	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sirpa	NCBI	NCBI:140885