2. Gene
  3. RGS17 - regulator of G protein signaling 17 Gene

RGS17 - regulator of G protein signaling 17 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RGSZ2; RGS-17; hRGS17

Gene ID: 26575 | Gene type: protein coding

About RGS17

Cytogenetic location: 6q25.2 Genomic coordinates (GRCh38): 6:153,004,459-153,131,282 (from NCBI)

This gene has 2 transcripts (splice variants), 207 orthologues and 23 paralogues. Broad expression in thyroid (RPKM 1.8), brain (RPKM 1.6) and 17 other tissues.

Summary

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

RGS17 Products(1)

mRNA Protein Name
NM_012419.5 NP_036551.3 regulator of G-protein signaling 17

RGS17 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (84 - 199)

  • 0
  • 100
  • 210 a.a.
Protein Preferred Names Protein Names

regulator of G-protein signaling 17

Recombinant RGS17 Proteins

Cat. No. Product Name Accession Purity
HY-P700384 RGS17 Protein, Human (GST) Q9UGC6 (M1-S210) ≥95%

Related Diseases

Diseases Alias
Jejunal Somatostatinoma

Jejunal Delta Cell Somatostatin Producing Tumor

Somatosatinoma Of Jejunum

Jejunal Somatostatin-Producing Neuroendocrine Tumor
Posterior Uveal Melanoma

Medium/Large Size Posterior Uveal Melanoma

Small Size Posterior Uveal Melanoma

Ciliary Body And Choroid Melanoma, Medium/Large Size

Ciliary Body And Choroid Melanoma, Small Size
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11911 RGS17 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RGS17 VGNC VGNC:45526
Macaca mulatta RGS17 VGNC VGNC:76731
Bos taurus RGS17 VGNC VGNC:33916
Felis catus RGS17 VGNC VGNC:102501
Rattus norvegicus RGS17 RGD RGD:1305515
Mus musculus RGS17 MGD MGI:1927469
Others RGS17 NCBI