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LSM1 - LSM1 homolog, mRNA degradation associated Gene

Also Known as CASM; YJL124C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27257

About LSM1

Cytogenetic location: 8p11.23 Genomic coordinates (GRCh38): 8:38,163,321-38,176,730 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 16.1), placenta (RPKM 14.6) and 25 other tissues.

Summary

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung Cancer, mesothelioma and breast Cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]

LSM1 Products (1)

mRNA	Protein	Name
NM_014462.3	NP_055277.1	U6 snRNA-associated Sm-like protein LSm1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14667819	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in histone mRNA catabolic process	IMP IMP: Inferred from mutant phenotype	18172165	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18559850	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18559850	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSM1 Protein Structure

LSM

0
100
133 a.a.

Protein Preferred Names	Protein Names
U6 snRNA-associated Sm-like protein LSm1	LSM1 homolog, U6 small nuclear RNA associated

LSM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LSM1	O15116	COMT	Homo sapiens	P21964-2	Y2H Pooling	32814053
Intra	LSM1	O15116	COMT	Homo sapiens	P21964-2	Validated Y2H	32814053
Intra	LSM1	O15116	COMT	Homo sapiens	P21964-2	Y2H Array	32814053
Intra	LSM1	O15116	BEX5	Homo sapiens	Q5H9J7	Validated Y2H	32296183
Intra	LSM1	O15116	BEX5	Homo sapiens	Q5H9J7	Y2H Array	32296183
Intra	LSM1	O15116	BEX5	Homo sapiens	Q5H9J7	Y2H Prey Pooling	32296183
Intra	LSM1	O15116	MCCD1	Homo sapiens	P59942	Validated Y2H	32296183
Intra	LSM1	O15116	MCCD1	Homo sapiens	P59942	Y2H Array	32296183
Intra	LSM1	O15116	MCCD1	Homo sapiens	P59942	Y2H Prey Pooling	32296183
Intra	LSM1	O15116	DAPL1	Homo sapiens	A0PJW8	Y2H Prey Pooling	32296183
Intra	LSM1	O15116	DAPL1	Homo sapiens	A0PJW8	Y2H Array	32296183
Intra	LSM1	O15116	PATL1	Homo sapiens	Q86TB9	Anti Tag CoIP	33961781
Intra	LSM1	O15116	PATL1	Homo sapiens	Q86TB9	Validated Y2H	32296183
Intra	LSM1	O15116	LSM2	Homo sapiens	Q9Y333	Y2H Prey Pooling	32296183
Intra	LSM1	O15116	LSM2	Homo sapiens	Q9Y333	GMS	19628699
Intra	LSM1	O15116	LSM2	Homo sapiens	Q9Y333	Ion Exchange Chrom	19628699
Intra	LSM1	O15116	LSM2	Homo sapiens	Q9Y333	Validated Y2H	32296183
Intra	LSM1	O15116	LSM2	Homo sapiens	Q9Y333	Y2H	15231747
Intra	LSM1	O15116	LSM2	Homo sapiens	Q9Y333	Y2H Array	32296183
Intra	LSM1	O15116	LSM2	Homo sapiens	Q9Y333	Anti Tag CoIP	33961781
Intra	LSM1	O15116	LSM3	Homo sapiens	P62310	Y2H Prey Pooling	25416956
Intra	LSM1	O15116	LSM3	Homo sapiens	P62310	Ion Exchange Chrom	19628699
Intra	LSM1	O15116	LSM3	Homo sapiens	P62310	Y2H Array	26871637
Intra	LSM1	O15116	LSM3	Homo sapiens	P62310	Y2H	15231747
Intra	LSM1	O15116	LSM3	Homo sapiens	P62310	GMS	19628699
Intra	LSM1	O15116	LSM3	Homo sapiens	P62310	Validated Y2H	25416956
Intra	LSM1	O15116	LSM3	Homo sapiens	P62310	Validated Y2H	26871637
Intra	LSM1	O15116	LSM3	Homo sapiens	P62310	Validated Y2H	32296183
Intra	LSM1	O15116	LSM3	Homo sapiens	P62310	Y2H Prey Pooling	26871637
Intra	LSM1	O15116	PSMB5	Homo sapiens	P28074	Validated Y2H	32296183
Intra	LSM1	O15116	PSMB5	Homo sapiens	P28074	Y2H	15231747
Intra	LSM1	O15116	PSMB8	Homo sapiens	P28062-2	Validated Y2H	32296183
Intra	LSM1	O15116	LSM4	Homo sapiens	Q9Y4Z0	Anti Tag CoIP	33961781
Intra	LSM1	O15116	LSM4	Homo sapiens	Q9Y4Z0	MAPPIT	25416956
Intra	LSM1	O15116	LSM4	Homo sapiens	Q9Y4Z0	GMS	19628699
Intra	LSM1	O15116	LSM4	Homo sapiens	Q9Y4Z0	Y2H	15231747
Intra	LSM1	O15116	LSM4	Homo sapiens	Q9Y4Z0	Ion Exchange Chrom	19628699
Intra	LSM1	O15116	LSM6	Homo sapiens	P62312	GMS	19628699
Intra	LSM1	O15116	LSM6	Homo sapiens	P62312	Anti Tag CoIP	33961781
Intra	LSM1	O15116	LSM6	Homo sapiens	P62312	Ion Exchange Chrom	19628699
Intra	LSM1	O15116	AGR3	Homo sapiens	Q8TD06	Validated Y2H	32296183
Intra	LSM1	O15116	AGR2	Homo sapiens	O95994	Validated Y2H	32296183
Intra	LSM1	O15116	TCL1B	Homo sapiens	O95988	Y2H Prey Pooling	32296183
Intra	LSM1	O15116	TCL1B	Homo sapiens	O95988	Validated Y2H	32296183
Intra	LSM1	O15116	TCL1B	Homo sapiens	O95988	Y2H Array	32296183
Intra	LSM1	O15116	GSTA4	Homo sapiens	O15217	Y2H Array	32296183
Intra	LSM1	O15116	GSTA4	Homo sapiens	O15217	Y2H Prey Pooling	32296183
Intra	LSM1	O15116	GSTA4	Homo sapiens	O15217	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LSM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70198	LSM1 Protein, Human (His)	O15116 (M1-Y133)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Non-Functioning Pancreatic Endocrine Tumor	Non Functioning Pancreatic Endocrine Tumor Non-Functioning Epts Non-Functioning Endocrine Pancreatic Tumors
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07852	LSM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20769	Lsm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27283	Lsm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LSM1	MGD	MGI:1914457
Rattus norvegicus	LSM1	RGD	RGD:1304967
Felis catus	LSM1	VGNC	VGNC:107342
Canis familiaris	LSM1	VGNC	VGNC:42838
Bos taurus	LSM1	VGNC	VGNC:31050
Others	LSM1	NCBI