LSM1 - LSM1 homolog, mRNA degradation associated Gene

Homo sapiens

Also known as CASM; YJL124C

Gene ID: 27257 | Gene type: protein coding

About LSM1

Cytogenetic location: 8p11.23 Genomic coordinates (GRCh38): 8:38,163,321-38,176,730 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 16.1), placenta (RPKM 14.6) and 25 other tissues.

Summary

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung Cancer, mesothelioma and breast Cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]

LSM1 Products(1)

mRNA	Protein	Name
NM_014462.3	NP_055277.1	U6 snRNA-associated Sm-like protein LSm1

LSM1 Protein Structure

LSM

0
100
133 a.a.

Protein Preferred Names

Protein Names

U6 snRNA-associated Sm-like protein LSm1

LSM1 homolog, U6 small nuclear RNA associated

Recombinant LSM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70198	LSM1 Protein, Human (His)	O15116 (M1-Y133)	≥95%

Related Diseases

Diseases

Alias

Non-Functioning Pancreatic Endocrine Tumor

Non Functioning Pancreatic Endocrine Tumor	Non-Functioning Epts
Non-Functioning Endocrine Pancreatic Tumors

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07852	LSM1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LSM1	MGD	MGI:1914457
Rattus norvegicus	LSM1	RGD	RGD:1304967
Felis catus	LSM1	VGNC	VGNC:107342
Canis familiaris	LSM1	VGNC	VGNC:42838
Bos taurus	LSM1	VGNC	VGNC:31050
Others	LSM1	NCBI