Sgk1 - serum/glucocorticoid regulated kinase 1 Gene

Also Known as Sgk

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29517

About Sgk1

Primary_assembly 1: 22,980,261-23,098,283 reverse strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 214 orthologues, 13 paralogues and is associated with 12 phenotypes. Biased expression in Kidney (RPKM 287.7), Thymus (RPKM 277.9) and 9 other tissues.

Summary

Enables 3-phosphoinositide-dependent protein kinase binding activity; protein serine/threonine kinase activity; and Tau Protein binding activity. Involved in several processes, including generation of neurons; glucocorticoid mediated signaling pathway; and learning or memory. Acts upstream of or within cellular response to Insulin stimulus; positive regulation of sodium ion transport; and regulation of protein localization. Located in neuron projection; nucleus; and perinuclear region of cytoplasm. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SGK1 (serum/glucocorticoid regulated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sgk1 Products (3)

mRNA Protein Name
NM_001193568.1 NP_001180497.1 serine/threonine-protein kinase Sgk1 isoform 1
NM_001193569.1 NP_001180498.1 serine/threonine-protein kinase Sgk1 isoform 2
NM_019232.3 NP_062105.2 serine/threonine-protein kinase Sgk1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3-phosphoinositide-dependent protein kinase binding IPI
IPI: Inferred from physical interaction
10357815 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
16982696 RGD
enables tau protein binding IPI
IPI: Inferred from physical interaction
16982696 RGD
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
17715136 RGD
involved in intracellular sodium ion homeostasis IDA
IDA: Inferred from direct assay
11250940 RGD
involved in long-term memory IMP
IMP: Inferred from mutant phenotype
11891330 RGD
involved in microtubule depolymerization IDA
IDA: Inferred from direct assay
16982696 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15795328 RGD
involved in negative regulation of microtubule polymerization IDA
IDA: Inferred from direct assay
16982696 RGD
involved in neuron projection morphogenesis IDA
IDA: Inferred from direct assay
16982696 RGD
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
16982696 RGD
involved in positive regulation of cell growth IDA
IDA: Inferred from direct assay
15795328 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
16049181 RGD
acts upstream of or within positive regulation of sodium ion transport IMP
IMP: Inferred from mutant phenotype
17715136 RGD
acts upstream of or within regulation of protein localization IMP
IMP: Inferred from mutant phenotype
17715136 RGD
involved in visual learning IMP
IMP: Inferred from mutant phenotype
14656333 RGD
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
10066787 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sgk1 Protein Structure

STKc_SGK

STKc_SGK: cd05575 (195 - 517)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 525 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Sgk1

  • serine/threonine protein kinase SGK

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15192 GSK 650394 Inhibitor 99.76% Unkown
HY-15193 EMD638683 Inhibitor 99.94% Unkown
HY-18607 SGK1-IN-1 Inhibitor 99.57% Unkown
HY-167832 PT109 Inhibitor 99.20% Unkown
HY-135893 SGK1-IN-2 Inhibitor 98.67% Unkown
HY-142686A SGK1-IN-3 hydrochloride Inhibitor 98.99% Unkown
HY-15193B EMD638683 (S-Form) Inhibitor 99.72% Unkown
HY-15193A EMD638683 (R-Form) Inhibitor 99.86% Unkown
HY-185412 SGK1-IN-9 Inhibitor / Unkown
HY-142686 SGK1-IN-3 Inhibitor / Unkown
HY-176823 PROTAC SGK3 degrader-2 Degrader / Unkown
HY-184333 SGK1-IN-10 Inhibitor / Unkown
HY-170933 SGK1-IN-6 Inhibitor / Unkown
HY-151009 308-R Inhibitor / Unkown
HY-128221 SGK1-IN-5 Inhibitor 98.2% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sgk1 NCBI NCBI:6446