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製品番号: HY-128221

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SGK1-IN-5

SGK1-IN-5 is a SGK1 inhibitor with an IC₅₀ of 0.003 μM. SGK1-IN-5 can be used for the research of osteoarthritis, rheumatism.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度 : 98.2%
CAS 番号: 1426214-51-8
分子式: C₁₇H₁₂Cl₂N₆O₂S
分子量:435.29

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

SGK1-IN-5 構造式

CAS 番号: 1426214-51-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

SGK1-IN-5 is a SGK1 inhibitor with an IC₅₀ of 0.003 μM. SGK1-IN-5 can be used for the research of osteoarthritis, rheumatism^[1].

IC₅₀ & Target

^[1]

SGK1

0.003 μM (IC₅₀)

SGK アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
U2OS	IC₅₀	1.4 μM Compound: 1	Inhibition of recombinant human SGK1 (S61 to L431, S422D) expressed in human U20S cells assessed as inhibition of GSK3beta phosphorylation after 6 hrs by fluorescence assay Inhibition of recombinant human SGK1 (S61 to L431, S422D) expressed in human U20S cells assessed as inhibition of GSK3beta phosphorylation after 6 hrs by fluorescence assay	[PMID: 24900601]
U2OS	IC₅₀	1.4 μM Compound: 14g	Inhibition of SGK1 in human U2OS cells assessed as phosphorylation of GSK3beta Inhibition of SGK1 in human U2OS cells assessed as phosphorylation of GSK3beta	[PMID: 25589934]

体外実験

SGK1-IN-5 (example 1) inhibits SGK-1 depenent phosphorylation of GSK3beta in U2OS cells, with an IC₅₀ of 1.4 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1426214-51-8
性状 Solid
分子量 435.29
分子式 C₁₇H₁₂Cl₂N₆O₂S
Color Light yellow to yellow
SMILES

O=S(C1=CC=CC(Cl)=C1Cl)(NC2=CC=C(C3=CN=C4C(NN=C4N)=N3)C=C2)=O
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Marc Nazare, et al. N-[4-(1H-PYRAZOLO[3,4-b]PYRAZIN-6-YL)-PHENYL]-SULFONAMIDES AND THEIR USE AS PHARMACEUTICALS. US20130072493A1.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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