Dhcr24 - 24-dehydrocholesterol reductase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 298298

Summary

Predicted to enable enzyme binding activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; and peptide antigen binding activity. Involved in several processes, including Ras protein signal transduction; negative regulation of cell population proliferation; and steroid metabolic process. Located in several cellular components, including cytoskeleton; cytosol; and nucleus. Human ortholog(s) of this gene implicated in lipid metabolism disorder. Orthologous to human DHCR24 (24-dehydrocholesterol reductase). [provided by Alliance of Genome Resources, Apr 2022]

Dhcr24 Products (1)

mRNA Protein Name
NM_001080148.2 NP_001073617.2 delta(24)-sterol reductase precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
15577914 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15577914 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
17210742 RGD
involved in steroid metabolic process IMP
IMP: Inferred from mutant phenotype
17210742 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

delta(24)-sterol reductase

  • 3-beta-hydroxysterol delta-24-reductase

  • seladin-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10016 E 2012 Modulator 97.01% Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-143228 SH-42 Inhibitor 99.87% Unkown
HY-164561 TASIN-30 99.96% Unkown
HY-148660 SFI003 Inducer 99.75% Unkown
HY-167709 Azacosterol Inhibitor 99.85% Unkown
HY-RS03726 DHCR24 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17385 Dhcr24 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23840 Dhcr24 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dhcr24 NCBI NCBI:1718