Hsp90aa1 - heat shock protein 90 alpha family class A member 1 Gene

Also Known as Hsp86; Hsp90; Hspca

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 299331

About Hsp90aa1

Primary_assembly 6: 129,702,383-129,707,268 reverse strand.mRatBN7.2:CM026979.1

This gene has 1 transcript (splice variant), 271 orthologues, 11 paralogues and is associated with 17 phenotypes. Biased expression in Brain (RPKM 2165.3), Testes (RPKM 1934.7) and 9 other tissues.

Summary

Enables several functions, including Rho GDP-dissociation inhibitor binding activity; nucleotide binding activity; and sulfonylurea receptor binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; positive regulation of lamellipodium assembly; and positive regulation of protein import into nucleus. Located in several cellular components, including basolateral plasma membrane; brush border membrane; and sperm mitochondrial sheath. Part of protein-containing complex. Biomarker of portal hypertension. Orthologous to human HSP90AA1 (heat shock protein 90 alpha family class A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Hsp90aa1 Products (1)

mRNA	Protein	Name
NM_175761.2	NP_786937.1	heat shock protein HSP 90-alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12755697	RGD
enables CTP binding	IDA IDA: Inferred from direct assay	12755697	RGD
enables GTP binding	IDA IDA: Inferred from direct assay	12755697	RGD
enables Rho GDP-dissociation inhibitor binding	IDA IDA: Inferred from direct assay	19910677	RGD
enables UTP binding	IDA IDA: Inferred from direct assay	12755697	RGD
enables dATP binding	IDA IDA: Inferred from direct assay	12755697	RGD
enables mRNA binding	IDA IDA: Inferred from direct assay	19703590	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15001530	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	8943293	RGD
enables sulfonylurea receptor binding	IPI IPI: Inferred from physical interaction	20427569	RGD
enables tau protein binding	IPI IPI: Inferred from physical interaction	19363271	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	20427569	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cardiac muscle cell apoptotic process	IEP IEP: Inferred from expression pattern	21620734	RGD
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	15302889	RGD
involved in positive regulation of cardiac muscle contraction	IEP IEP: Inferred from expression pattern	21620734	RGD
involved in positive regulation of cell size	IMP IMP: Inferred from mutant phenotype	20980790	RGD
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	15302889	RGD
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	20980790	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	EXP EXP: Inferred from Experiment	15152036	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: Inferred from direct assay	15152036	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	22860061	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	15229138	RGD
involved in response to salt stress	IEP IEP: Inferred from expression pattern	15497505	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	24478030	RGD
involved in skeletal muscle contraction	IEP IEP: Inferred from expression pattern	20851858	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15497505	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	15497505	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	15497505	RGD
located in cell surface	IDA IDA: Inferred from direct assay	15302889	RGD
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	15497505	RGD
located in myelin sheath	IDA IDA: Inferred from direct assay	17960831	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	20796173	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20796173	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	20796173	RGD
located in sperm flagellum	IDA IDA: Inferred from direct assay	24478030	RGD
located in sperm mitochondrial sheath	IDA IDA: Inferred from direct assay	24478030	RGD
located in sperm plasma membrane	IDA IDA: Inferred from direct assay	24478030	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hsp90aa1 Protein Structure

PRK14083

0
200
400
600
733 a.a.

Protein Preferred Names	Protein Names
heat shock protein HSP 90-alpha	HSP 86 heat shock 86 kDa heat shock protein 1, alpha heat shock protein 86 heat shock protein 90, alpha (cytosolic), class A member 1 heat shock protein 90kDa alpha family class A member 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N5074	Terrestrosin D		99.30%	Unkown
HY-RS06415	HSP90AA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183319	Anticancer agent 320		/	Unkown
HY-183760	AChE/BChE-IN-37	Inhibitor	/	Unkown
HY-187191	Autophagy-IN/Ferroptosis inducer-modulator-1		/	Unkown
HY-RS06416	Hsp90aa1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06417	Hsp90aa1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N10379	19-epi-Scholaricine		99.14%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hsp90aa1	NCBI	NCBI:3320