HSP90AA1 - heat shock protein 90 alpha family class A member 1 Gene
Also Known as EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; Hsp103; HSPCAL1; HSPCAL4; HEL-S-65p
Species: Homo sapiens
About HSP90AA1
This gene has 10 transcripts (splice variants), 298 orthologues, 3 paralogues and is associated with 66 phenotypes. Ubiquitous expression in brain (RPKM 360.6), testis (RPKM 312.5) and 25 other tissues.
Summary
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
HSP90AA1 Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001017963.3 | NP_001017963.2 | heat shock protein HSP 90-alpha isoform 1 |
| NM_005348.4 | NP_005339.3 | heat shock protein HSP 90-alpha isoform 2 |
| XM_011536718.3 | XP_011535020.1 | heat shock protein HSP 90-alpha isoform X1 |
| NM_001017963.3 | NP_001017963.2 | heat shock protein HSP 90-alpha isoform 1 |
| NM_005348.4 | NP_005339.3 | heat shock protein HSP 90-alpha isoform 2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables ATP binding |
IDA
IDA: Inferred from direct assay
|
27353360 | GOA |
| enables ATP hydrolysis activity |
IDA
IDA: Inferred from direct assay
|
15937123 | GOA |
| enables DNA polymerase binding |
IPI
IPI: Inferred from physical interaction
|
10197982 | GOA |
| enables GTPase binding |
IPI
IPI: Inferred from physical interaction
|
24337748 | GOA |
| enables TPR domain binding |
IDA
IDA: Inferred from direct assay
|
9660753 | GOA |
| enables disordered domain specific binding |
IPI
IPI: Inferred from physical interaction
|
15713458 | GOA |
| enables histone deacetylase binding |
IPI
IPI: Inferred from physical interaction
|
16809764 | GOA |
| enables identical protein binding |
IDA
IDA: Inferred from direct assay
|
29127155 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
8289821 | GOA |
| enables nitric-oxide synthase regulator activity |
IDA
IDA: Inferred from direct assay
|
15937123 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9660753 | GOA |
| enables protein homodimerization activity |
IDA
IDA: Inferred from direct assay
|
29127155 | GOA |
| enables protein tyrosine kinase binding |
IPI
IPI: Inferred from physical interaction
|
20353823 | GOA |
| enables scaffold protein binding |
IPI
IPI: Inferred from physical interaction
|
10409742 | GOA |
| enables tau protein binding |
IPI
IPI: Inferred from physical interaction
|
19363271 | GOA |
| enables ubiquitin protein ligase binding |
IPI
IPI: Inferred from physical interaction
|
16207813 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
10791971 | GOA |
| located in mitochondrion |
IDA
IDA: Inferred from direct assay
|
25609812 | GOA |
| part of protein-containing complex |
IDA
IDA: Inferred from direct assay
|
23349634 | GOA |
HSP90AA1 Protein Structure
HATPase_c: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (42 - 192)
HSP90: Hsp90 protein (196 - 732)
- 0
- 200
- 400
- 600
- 732 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
heat shock protein HSP 90-alpha |
|
|
HSP90AA1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
HSP90AA1 | P07900 | ADAMTSL4 | Homo sapiens | Q6UY14-3 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | ADAMTSL4 | Homo sapiens | Q6UY14-3 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | ADAMTSL4 | Homo sapiens | Q6UY14-3 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | FKBP4 | Homo sapiens | Q02790 | 21360678 | |
|
Intra
|
HSP90AA1 | P07900 | FKBP4 | Homo sapiens | Q02790 | 19875381 | |
|
Intra
|
HSP90AA1 | P07900 | PTGES3 | Homo sapiens | Q15185 | 9817749 | |
|
Intra
|
HSP90AA1 | P07900 | PTGES3 | Homo sapiens | Q15185 | 25036637 | |
|
Intra
|
HSP90AA1 | P07900 | PTGES3 | Homo sapiens | Q15185 | 19875381 | |
|
Intra
|
HSP90AA1 | P07900 | CDK15 | Homo sapiens | Q96Q40 | 25036637 | |
|
Intra
|
HSP90AA1 | P07900 | CERS2 | Homo sapiens | Q96G23 | 20195357 | |
|
Intra
|
HSP90AA1 | P07900 | CERS2 | Homo sapiens | Q96G23 | 20195357 | |
|
Intra
|
HSP90AA1 | P07900 | CDK9 | Homo sapiens | P50750 | 33961781 | |
|
Intra
|
HSP90AA1 | P07900 | CAMK2A | Homo sapiens | Q9UQM7 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | CAMK2A | Homo sapiens | Q9UQM7 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | CAMK2A | Homo sapiens | Q9UQM7 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | MOS | Homo sapiens | P00540 | 25036637 | |
|
Intra
|
HSP90AA1 | P07900 | KAT5 | Homo sapiens | Q92993-2 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | KAT5 | Homo sapiens | Q92993-2 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | KAT5 | Homo sapiens | Q92993-2 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | CHORDC1 | Homo sapiens | Q9UHD1 | 19875381 | |
|
Intra
|
HSP90AA1 | P07900 | TOMM70 | Homo sapiens | O94826 | 33990585 | |
|
Intra
|
HSP90AA1 | P07900 | CDC37L1 | Homo sapiens | Q7L3B6 | 33961781 | |
|
Intra
|
HSP90AA1 | P07900 | CDC37 | Homo sapiens | Q16543 | 19875381 | |
|
Intra
|
HSP90AA1 | P07900 | CDC37 | Homo sapiens | Q16543 | 26496610 | |
|
Intra
|
HSP90AA1 | P07900 | CDC37 | Homo sapiens | Q16543 | 33961781 | |
|
Intra
|
HSP90AA1 | P07900 | CDC37 | Homo sapiens | Q16543 | 21360678 | |
|
Intra
|
HSP90AA1 | P07900 | PPP5C | Homo sapiens | P53041 | 19875381 | |
|
Intra
|
HSP90AA1 | P07900 | PPP5C | Homo sapiens | P53041 | 35271311 | |
|
Intra
|
HSP90AA1 | P07900 | EGFR | Homo sapiens | P00533 | 20029029 | |
|
Intra
|
HSP90AA1 | P07900 | FKBP5 | Homo sapiens | Q13451 | 21360678 | |
|
Intra
|
HSP90AA1 | P07900 | FKBP5 | Homo sapiens | Q13451 | 19875381 | |
|
Intra
|
HSP90AA1 | P07900 | CCDC117 | Homo sapiens | Q8IWD4 | 19875381 | |
|
Intra
|
HSP90AA1 | P07900 | RPS3A | Homo sapiens | P61247 | 16169070 | |
|
Intra
|
HSP90AA1 | P07900 | RPS3A | Homo sapiens | P61247 | 25416956 | |
|
Intra
|
HSP90AA1 | P07900 | RPAP3 | Homo sapiens | Q9H6T3 | 35271311 | |
|
Intra
|
HSP90AA1 | P07900 | RPAP3 | Homo sapiens | Q9H6T3 | 25036637 | |
|
Intra
|
HSP90AA1 | P07900 | RPAP3 | Homo sapiens | Q9H6T3 | 19875381 | |
|
Intra
|
HSP90AA1 | P07900 | RPAP3 | Homo sapiens | Q9H6T3 | 21360678 | |
|
Intra
|
HSP90AA1 | P07900 | STUB1 | Homo sapiens | Q9UNE7 | 16275660 | |
|
Intra
|
HSP90AA1 | P07900 | STUB1 | Homo sapiens | Q9UNE7 | 21360678 | |
|
Intra
|
HSP90AA1 | P07900 | STUB1 | Homo sapiens | Q9UNE7 | 16275660 | |
|
Intra
|
HSP90AA1 | P07900 | STUB1 | Homo sapiens | Q9UNE7 | 16307917 | |
|
Intra
|
HSP90AA1 | P07900 | STUB1 | Homo sapiens | Q9UNE7 | 19875381 | |
|
Intra
|
HSP90AA1 | P07900 | MAP3K14 | Homo sapiens | Q99558 | 14743216 | |
|
Intra
|
HSP90AA1 | P07900 | MAP3K7 | Homo sapiens | O43318-2 | 14743216 | |
|
Intra
|
HSP90AA1 | P07900 | RAF1 | Homo sapiens | P04049 | 25036637 | |
|
Intra
|
HSP90AA1 | P07900 | AHSA1 | Homo sapiens | O95433 | 35271311 | |
|
Intra
|
HSP90AA1 | P07900 | AHSA1 | Homo sapiens | O95433 | 19875381 | |
|
Intra
|
HSP90AA1 | P07900 | PRKACA | Homo sapiens | P17612 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | PRKACA | Homo sapiens | P17612 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | PRKACA | Homo sapiens | P17612 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | CTNNB1 | Homo sapiens | P35222 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | CTNNB1 | Homo sapiens | P35222 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | CTNNB1 | Homo sapiens | P35222 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | NR3C1 | Homo sapiens | P04150 | 20195357 | |
|
Intra
|
HSP90AA1 | P07900 | FYN | Homo sapiens | P06241 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | FYN | Homo sapiens | P06241 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | FYN | Homo sapiens | P06241 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | TXN | Homo sapiens | P10599 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | TXN | Homo sapiens | P10599 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | TXN | Homo sapiens | P10599 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | SRC | Homo sapiens | P12931 | 16844778 | |
|
Intra
|
HSP90AA1 | P07900 | ERBB2 | Homo sapiens | P04626 | 24658140 | |
|
Intra
|
HSP90AA1 | P07900 | AMHR2 | Homo sapiens | Q16671 | 25036637 | |
|
Intra
|
HSP90AA1 | P07900 | KSR2 | Homo sapiens | Q6VAB6 | 25036637 | |
|
Intra
|
HSP90AA1 | P07900 | PAFAH1B1 | Homo sapiens | P43034 | 20133715 | |
|
Intra
|
HSP90AA1 | P07900 | PAFAH1B1 | Homo sapiens | P43034 | 20133715 | |
|
Intra
|
HSP90AA1 | P07900 | FKBP8 | Homo sapiens | Q14318 | 17024179 | |
|
Intra
|
HSP90AA1 | P07900 | FKBP8 | Homo sapiens | Q14318 | 21360678 | |
|
Intra
|
HSP90AA1 | P07900 | IP6K2 | Homo sapiens | Q9UHH9 | 18195352 | |
|
Intra
|
HSP90AA1 | P07900 | IP6K2 | Homo sapiens | Q9UHH9 | 18195352 | |
|
Intra
|
HSP90AA1 | P07900 | CHUK | Homo sapiens | O15111 | 14743216 | |
|
Intra
|
HSP90AA1 | P07900 | CHUK | Homo sapiens | O15111 | 33961781 | |
|
Intra
|
HSP90AA1 | P07900 | CHUK | Homo sapiens | O15111 | 19875381 | |
|
Intra
|
HSP90AA1 | P07900 | IKBKG | Homo sapiens | Q9Y6K9 | 14743216 | |
|
Intra
|
HSP90AA1 | P07900 | IKBKG | Homo sapiens | Q9Y6K9 | 19875381 | |
|
Intra
|
HSP90AA1 | P07900 | BTBD1 | Homo sapiens | Q9H0C5 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | BTBD1 | Homo sapiens | Q9H0C5 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | BTBD1 | Homo sapiens | Q9H0C5 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | BTBD1 | Homo sapiens | Q9H0C5 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | HSP90AB1 | Homo sapiens | Q6PK50 | 25036637 | |
|
Intra
|
HSP90AA1 | P07900 | UNC45B | Homo sapiens | Q8IWX7 | 25036637 | |
|
Intra
|
HSP90AA1 | P07900 | CYTH1 | Homo sapiens | Q15438 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | CYTH1 | Homo sapiens | Q15438 | 32814053 | |
|
Intra
|
HSP90AA1 | P07900 | CYTH1 | Homo sapiens | Q15438 | 32814053 | |
|
Cross
|
HSP90AA1 | P07900 | S100a1 | Rattus norvegicus | P35467 | 14638689 |
Recombinant HSP90AA1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P72238 | HSP90AA1 Protein, Human (His-SUMO) | P07900-1 (D9-D232) | ≥ 90%, as determined by reducing SDS-PAGE. |
HSP90AA1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80714 | Hsp90 alpha/beta Antibody (YA356) | WB, IHC-F, IHC-P, ICC/IF, IP | Human, Mouse, Rat |
| HY-P80714A | Hsp90 alpha/beta Antibody (YA356)(PBS only) | WB, IHC-F, IHC-P, ICC/IF, IP | Human, Mouse, Rat |
| HY-P83995 | Hsp90 alpha Antibody (YA3692) | WB, IHC-P, FC, ELISA | Human, Mouse, Monkey |
| HY-P83995A | Hsp90 alpha Antibody (YA3692)(PBS only) | WB, IHC-P, FC, ELISA | Human, Mouse, Monkey |
| HY-P87175 | Hsp90 alpha Antibody(YA6866) | WB, IHC-P, ICC/IF, FC | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Leukemia, Chronic Myeloid |
|
|
| Complement Component 7 Deficiency |
|
|
| Long Qt Syndrome |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Myeloma, Multiple |
|
|
| Retinitis Pigmentosa |
|
|
| Adenocarcinoma |
|
|
| Candidiasis |
|
|
| Neuroblastoma |
|
|
| Spastic Ataxia |
|
|
| Anaplastic Large Cell Lymphoma |
|
|
| Spinal And Bulbar Muscular Atrophy, X-Linked 1 |
|
|
| Machado-Joseph Disease |
|
|
| Cortisone Reductase Deficiency 2 |
|
|
| Microcephaly 7, Primary, Autosomal Recessive |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Cystic Fibrosis |
|
|
| Herpes Simplex |
|
|
| Eye Disease |
|
|
| Pheochromocytoma |
|
|
| Melanoma |
|
|
| Malaria |
|
|
| Epidermolysis Bullosa Acquisita |
|
|
| Leukemia, Acute Myeloid |
|
|
| Axonal Neuropathy |
|
|
| Colorectal Cancer |
|
|
| Retinitis Pigmentosa 61 |
|
|
| Muscular Dystrophy |
|
|
| Breast Cancer |
|
|
| Influenza |
|
|
| Huntington Disease |
|
|
| Lung Cancer |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Gastric Cancer |
|
|
| Varicocele |
|
|
| Multiple Sclerosis |
|
|
| Nervous System Disease |
|
|
| Autosomal Dominant Cerebellar Ataxia |
|
|
| Pancreatic Adenocarcinoma |
|
|
| Bladder Cancer |
|
|
| Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome |
|
|
| Ovarian Cancer |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Prostate Cancer |
|
|
| Testicular Cancer |
|
|
| Liver Carcinoma In Situ |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Gastrointestinal Stromal Tumor |
|
|
| Peripheral Nervous System Disease |
|
|
| Pick Disease Of Brain |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Disease By Infectious Agent |
|
|
| Asthma |
|
|
| Pancreatic Cancer |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Burkitt Lymphoma |
|
|
| Hand-Foot-Genital Syndrome |
|
|
| Glioblastoma |
|
|
| Peutz-Jeghers Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | HSP90AA1 | VGNC | VGNC:108305 |
| Rattus norvegicus | HSP90AA1 | RGD | RGD:631409 |
| Canis familiaris | HSP90AA1 | VGNC | VGNC:50532 |
| Mus musculus | HSP90AA1 | MGD | MGI:96250 |
| Bos taurus | HSP90AA1 | VGNC | VGNC:53940 |
| Felis catus | HSP90AA1 | VGNC | VGNC:80954 |
| Others | HSP90AA1 | NCBI |