CDK15 - cyclin dependent kinase 15 Gene

Also Known as PFTK2; ALS2CR7; PFTAIRE2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 65061

About CDK15

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:201,806,429-201,895,550 (from NCBI)

This gene has 10 transcripts (splice variants), 198 orthologues and 26 paralogues. Biased expression in ovary (RPKM 1.2), gall bladder (RPKM 0.5) and 13 other tissues.

Summary

Enables protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CDK15 Products (4)

mRNA Protein Name
NM_001261435.1 NP_001248364.1 cyclin-dependent kinase 15 isoform 1
NM_001261436.1 NP_001248365.1 cyclin-dependent kinase 15 isoform 2
NM_001366386.2 NP_001353315.1 cyclin-dependent kinase 15 isoform 4
NM_139158.2 NP_631897.1 cyclin-dependent kinase 15 isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22939624 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
24866247 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK15 Protein Structure

Pkinase

Pkinase: Protein kinase domain (105 - 387)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 429 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 15

  • PFTAIRE protein kinase 2

CDK15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CDK15 Q96Q40 HSP90AA1 Homo sapiens P07900
Anti Tag CoIP
33961781
Intra
CDK15 Q96Q40 FKBP5 Homo sapiens Q13451
Lumier
25036637
Intra
CDK15 Q96Q40 FKBP5 Homo sapiens Q13451
Anti Tag CoIP
33961781
Intra
CDK15 Q96Q40 FKBP5 Homo sapiens Q13451
TAP
23602568
Intra
CDK15 Q96Q40 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
22939624
Intra
CDK15 Q96Q40 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis 2, Juvenile

  • ALS2

  • Als, Juvenile

  • Alsj

  • Amyotrophic Lateral Sclerosis Type 2

  • Amyotrophic Lateral Sclerosis 2

  • Amyotrophic Lateral Sclerosis Type 2, Juvenile

  • Amyotrophic Lateral Sclerosis Juvenile

  • Amyotrophic Lateral Sclerosis Juvenile 2

  • Sclerosis, Lateral, Amyotrophic, Type Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS26883 Cdk15 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CDK15 RGD RGD:1306205
Macaca mulatta CDK15 VGNC VGNC:70951
Felis catus CDK15 VGNC VGNC:60696
Bos taurus CDK15 VGNC VGNC:106681
Canis familiaris CDK15 VGNC VGNC:39047
Mus musculus CDK15 MGD MGI:3583944
Others CDK15 NCBI