HARS1 - histidyl-tRNA synthetase 1 Gene

Also Known as HRS; HARS; CMT2W; USH3B

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 3035

Summary

Aminoacyl-tRNA synthetases are a class of Enzymes that charge tRNAs with their cognate Amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

HARS1 Products (1)

mRNA Protein Name
NM_001289092.2 NP_001276021.1 histidine--tRNA ligase, cytoplasmic isoform 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
29235198 GOA
enables histidine-tRNA ligase activity IDA
IDA: Inferred from direct assay
29235198 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
22958643 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
29235198 GOA
Biological Process GO Annotation Evidence References Source
involved in histidyl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
29235198 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21464306 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histidine--tRNA ligase, cytoplasmic

  • HisRS

  • Jo-1 antigen

  • histidine translase

HARS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HARS1 P12081 HARS1 Homo sapiens P12081
X-Ray Diffraction
22958643
Intra
HARS1 P12081 HARS1 Homo sapiens P12081
GMS
22958643
Intra
HARS1 P12081 TNIK Homo sapiens Q9UKE5
Y2H
17043677
Intra
HARS1 P12081 MTNR1B Homo sapiens P49286
Y2H
26514267
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HARS1 Proteins

Cat. No. Product Name Accession Purity
HY-P73933 HARS/HisRS Protein, Human (sf9, His) P12081-1/NP_002100.2 (A2-C509) ≥ 90%, as determined by reducing SDS-PAGE.

HARS1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81278B HARS Antibody (YA978) WB, IP Human
HY-P81278BA HARS Antibody (YA978)(PBS only) WB, IP Human

Related Agents

  • Clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990782 Efzofitimod 99.29% Phase 3