HMOX2 - heme oxygenase 2 Gene
Also Known as HO-2
Species: Homo sapiens
About HMOX2
This gene has 18 transcripts (splice variants), 1 gene allele, 255 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 23.0), brain (RPKM 16.1) and 25 other tissues.
Summary
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
HMOX2 Products (9)
| mRNA | Protein | Name |
|---|---|---|
| NM_001127204.2 | NP_001120676.1 | heme oxygenase 2 isoform b |
| NM_001127205.2 | NP_001120677.1 | heme oxygenase 2 isoform b |
| NM_001127206.3 | NP_001120678.1 | heme oxygenase 2 isoform b |
| NM_001286267.2 | NP_001273196.1 | heme oxygenase 2 isoform a |
| NM_001286268.2 | NP_001273197.1 | heme oxygenase 2 isoform b |
| NM_001286269.2 | NP_001273198.1 | heme oxygenase 2 isoform b |
| NM_001286270.2 | NP_001273199.1 | heme oxygenase 2 isoform b |
| NM_001286271.2 | NP_001273200.1 | heme oxygenase 2 isoform c |
| NM_002134.4 | NP_002125.3 | heme oxygenase 2 isoform b |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables heme oxygenase (decyclizing) activity |
IDA
IDA: Inferred from direct assay
|
1575508 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
15528406 | GOA |
| Biological Process GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| involved in response to hypoxia |
IDA
IDA: Inferred from direct assay
|
15528406 | GOA |
| Cellular Component GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
15528406 | GOA |
HMOX2 Protein Structure
Heme_oxygenase: Heme oxygenase (32 - 236)
- 0
- 100
- 200
- 300
- 316 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
heme oxygenase 2 |
|
HMOX2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
HMOX2 | P30519 | RETREG3 | Homo sapiens | Q86VR2 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | RETREG3 | Homo sapiens | Q86VR2 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | RETREG3 | Homo sapiens | Q86VR2 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | RUSC1-AS1 | Homo sapiens | Q66K80 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | RUSC1-AS1 | Homo sapiens | Q66K80 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | RUSC1-AS1 | Homo sapiens | Q66K80 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | SLC30A8 | Homo sapiens | Q8IWU4 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | SLC30A8 | Homo sapiens | Q8IWU4 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | SLC30A8 | Homo sapiens | Q8IWU4 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | SGPL1 | Homo sapiens | O95470 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | SGPL1 | Homo sapiens | O95470 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | VMA21 | Homo sapiens | Q3ZAQ7 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | VMA21 | Homo sapiens | Q3ZAQ7 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | VMA21 | Homo sapiens | Q3ZAQ7 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | ELOVL5 | Homo sapiens | Q9NYP7 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | ELOVL5 | Homo sapiens | Q9NYP7 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | ELOVL5 | Homo sapiens | Q9NYP7 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | ARL13B | Homo sapiens | Q3SXY8 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | ARL13B | Homo sapiens | Q3SXY8 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | ARL13B | Homo sapiens | Q3SXY8 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | TRIM69 | Homo sapiens | Q86WT6-2 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | TRIM69 | Homo sapiens | Q86WT6-2 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | TRIM69 | Homo sapiens | Q86WT6-2 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | KCNJ6 | Homo sapiens | P48051 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | KCNJ6 | Homo sapiens | P48051 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | KCNJ6 | Homo sapiens | P48051 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | STOM | Homo sapiens | P27105 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | STOM | Homo sapiens | P27105 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | ASGR2 | Homo sapiens | P07307-3 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | ASGR2 | Homo sapiens | P07307-3 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | GPR152 | Homo sapiens | Q8TDT2 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | ZC2HC1C | Homo sapiens | Q53FD0-2 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | ZC2HC1C | Homo sapiens | Q53FD0-2 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | ZC2HC1C | Homo sapiens | Q53FD0-2 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | LRRC56 | Homo sapiens | Q8IYG6 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | LRRC56 | Homo sapiens | Q8IYG6 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | LRRC56 | Homo sapiens | Q8IYG6 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | CRB3 | Homo sapiens | Q9BUF7-2 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | CRB3 | Homo sapiens | Q9BUF7-2 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | CRB3 | Homo sapiens | Q9BUF7-2 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | SSMEM1 | Homo sapiens | Q8WWF3 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | SSMEM1 | Homo sapiens | Q8WWF3 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | SSMEM1 | Homo sapiens | Q8WWF3 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | C3orf36 | Homo sapiens | Q3SXR2 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | C3orf36 | Homo sapiens | Q3SXR2 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | C3orf36 | Homo sapiens | Q3SXR2 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | RNASEK | Homo sapiens | Q6P5S7 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | RNASEK | Homo sapiens | Q6P5S7 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | RNASEK | Homo sapiens | Q6P5S7 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | ELOVL4 | Homo sapiens | Q9GZR5 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | GET1 | Homo sapiens | O00258 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | GET1 | Homo sapiens | O00258 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | FAM210B | Homo sapiens | Q96KR6 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | FAM210B | Homo sapiens | Q96KR6 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | FAM210B | Homo sapiens | Q96KR6 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | UBE2A | Homo sapiens | P49459 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | UBE2A | Homo sapiens | P49459 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | UBE2A | Homo sapiens | P49459 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | NUDT1 | Homo sapiens | P36639-4 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | NUDT1 | Homo sapiens | P36639-4 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | NUDT1 | Homo sapiens | P36639-4 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | MLST8 | Homo sapiens | A0A0A0MR05 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | MLST8 | Homo sapiens | A0A0A0MR05 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | MLST8 | Homo sapiens | A0A0A0MR05 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | MRM1 | Homo sapiens | Q6IN84-2 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | MRM1 | Homo sapiens | Q6IN84-2 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | MRM1 | Homo sapiens | Q6IN84-2 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | CNST | Homo sapiens | Q6PJW8-3 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | CNST | Homo sapiens | Q6PJW8-3 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | CNST | Homo sapiens | Q6PJW8-3 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | LAPTM5 | Homo sapiens | Q13571 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | LAPTM5 | Homo sapiens | Q13571 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | LAPTM5 | Homo sapiens | Q13571 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | POLR2I | Homo sapiens | P36954 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | POLR2I | Homo sapiens | P36954 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | POLR2I | Homo sapiens | P36954 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | ELL2 | Homo sapiens | O00472 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | ELL2 | Homo sapiens | O00472 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | ELL2 | Homo sapiens | O00472 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | CBX4 | Homo sapiens | O00257-3 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | CBX4 | Homo sapiens | O00257-3 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | CBX4 | Homo sapiens | O00257-3 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | FYN | Homo sapiens | P06241 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | FYN | Homo sapiens | P06241 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | FYN | Homo sapiens | P06241 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | SYT1 | Homo sapiens | P21579 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | SYT1 | Homo sapiens | P21579 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | ARL6IP4 | Homo sapiens | Q66PJ3-4 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | ARL6IP4 | Homo sapiens | Q66PJ3-4 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | ARL6IP4 | Homo sapiens | Q66PJ3-4 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | SNW1 | Homo sapiens | Q13573 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | SNW1 | Homo sapiens | Q13573 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | SNW1 | Homo sapiens | Q13573 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | TMX2 | Homo sapiens | Q9Y320 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | TMX2 | Homo sapiens | Q9Y320 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | TMX2 | Homo sapiens | Q9Y320 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | CIMAP1D | Homo sapiens | Q3SX64 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | CIMAP1D | Homo sapiens | Q3SX64 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | CIMAP1D | Homo sapiens | Q3SX64 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | MGST3 | Homo sapiens | O14880 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | MGST3 | Homo sapiens | O14880 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | NUP54 | Homo sapiens | Q7Z3B4 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | NUP54 | Homo sapiens | Q7Z3B4 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | NUP54 | Homo sapiens | Q7Z3B4 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | BCL2L13 | Homo sapiens | Q9BXK5 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | BCL2L13 | Homo sapiens | Q9BXK5 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | BCL2L13 | Homo sapiens | Q9BXK5 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | CD79A | Homo sapiens | P11912 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | CD79A | Homo sapiens | P11912 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
HMOX2 | P30519 | BAAT | Homo sapiens | Q14032 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | BAAT | Homo sapiens | Q14032 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | BAAT | Homo sapiens | Q14032 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | SEMA4G | Homo sapiens | Q9NTN9-3 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | SEMA4G | Homo sapiens | Q9NTN9-3 | 32814053 | |
|
Intra
|
HMOX2 | P30519 | SEMA4G | Homo sapiens | Q9NTN9-3 | 32814053 |
Recombinant HMOX2 Proteins
| Cat. No. | Nom du produit | Accession | Pureté |
|---|---|---|---|
| HY-P79126 | HO-2/HMOX2 Protein, Human (His) | P30519-1 (S2-L291) | ≥ 95%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Neonatal Jaundice |
|
|
| Gastroparesis |
|
|
| Hemochromatosis, Type 2b |
|
|
| Inflammatory Bowel Disease 30 |
|
|
| Kernicterus |
|
|
| Porphyria, Acute Intermittent |
|
|
| Hirschsprung Disease 1 |
|
|
| Renovascular Hypertension |
|
|
| Gilbert Syndrome |
|
|
| Bilirubin Metabolic Disorder |
|
|
| Deficiency Anemia |
|
|
| Hypertension, Essential |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | HMOX2 | VGNC | VGNC:73489 |
| Rattus norvegicus | HMOX2 | RGD | RGD:67402 |
| Mus musculus | HMOX2 | MGD | MGI:109373 |
| Felis catus | HMOX2 | VGNC | VGNC:67599 |
| Bos taurus | HMOX2 | VGNC | VGNC:29886 |
| Canis familiaris | HMOX2 | VGNC | VGNC:41720 |
| Others | HMOX2 | NCBI |