HMOX2 - heme oxygenase 2 Gene

Also Known as HO-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3163

About HMOX2

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,474,736-4,510,347 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele, 255 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 23.0), brain (RPKM 16.1) and 25 other tissues.

Summary

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

HMOX2 Products (9)

mRNA Protein Name
NM_001127204.2 NP_001120676.1 heme oxygenase 2 isoform b
NM_001127205.2 NP_001120677.1 heme oxygenase 2 isoform b
NM_001127206.3 NP_001120678.1 heme oxygenase 2 isoform b
NM_001286267.2 NP_001273196.1 heme oxygenase 2 isoform a
NM_001286268.2 NP_001273197.1 heme oxygenase 2 isoform b
NM_001286269.2 NP_001273198.1 heme oxygenase 2 isoform b
NM_001286270.2 NP_001273199.1 heme oxygenase 2 isoform b
NM_001286271.2 NP_001273200.1 heme oxygenase 2 isoform c
NM_002134.4 NP_002125.3 heme oxygenase 2 isoform b
Molecular Function GO Annotation Evidence Références Source
enables heme oxygenase (decyclizing) activity IDA
IDA: Inferred from direct assay
1575508 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15528406 GOA
Biological Process GO Annotation Evidence Références Source
involved in response to hypoxia IDA
IDA: Inferred from direct assay
15528406 GOA
Cellular Component GO Annotation Evidence Références Source
located in plasma membrane IDA
IDA: Inferred from direct assay
15528406 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HMOX2 Protein Structure

Heme_oxygenase

Heme_oxygenase: Heme oxygenase (32 - 236)

  • 0
  • 100
  • 200
  • 300
  • 316 a.a.
Protein Preferred Names Protein Names

heme oxygenase 2

  • heme oxygenase (decycling) 2

HMOX2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
HMOX2 P30519 RETREG3 Homo sapiens Q86VR2 32296183
Intra
HMOX2 P30519 RETREG3 Homo sapiens Q86VR2 32296183
Intra
HMOX2 P30519 RETREG3 Homo sapiens Q86VR2 32296183
Intra
HMOX2 P30519 RUSC1-AS1 Homo sapiens Q66K80 32814053
Intra
HMOX2 P30519 RUSC1-AS1 Homo sapiens Q66K80 32814053
Intra
HMOX2 P30519 RUSC1-AS1 Homo sapiens Q66K80 32814053
Intra
HMOX2 P30519 SLC30A8 Homo sapiens Q8IWU4 32296183
Intra
HMOX2 P30519 SLC30A8 Homo sapiens Q8IWU4 32296183
Intra
HMOX2 P30519 SLC30A8 Homo sapiens Q8IWU4 32296183
Intra
HMOX2 P30519 SGPL1 Homo sapiens O95470 32296183
Intra
HMOX2 P30519 SGPL1 Homo sapiens O95470 32296183
Intra
HMOX2 P30519 VMA21 Homo sapiens Q3ZAQ7 32296183
Intra
HMOX2 P30519 VMA21 Homo sapiens Q3ZAQ7 32296183
Intra
HMOX2 P30519 VMA21 Homo sapiens Q3ZAQ7 32296183
Intra
HMOX2 P30519 ELOVL5 Homo sapiens Q9NYP7 32296183
Intra
HMOX2 P30519 ELOVL5 Homo sapiens Q9NYP7 32296183
Intra
HMOX2 P30519 ELOVL5 Homo sapiens Q9NYP7 32296183
Intra
HMOX2 P30519 ARL13B Homo sapiens Q3SXY8 32296183
Intra
HMOX2 P30519 ARL13B Homo sapiens Q3SXY8 32296183
Intra
HMOX2 P30519 ARL13B Homo sapiens Q3SXY8 32296183
Intra
HMOX2 P30519 TRIM69 Homo sapiens Q86WT6-2 32814053
Intra
HMOX2 P30519 TRIM69 Homo sapiens Q86WT6-2 32814053
Intra
HMOX2 P30519 TRIM69 Homo sapiens Q86WT6-2 32814053
Intra
HMOX2 P30519 GPX8 Homo sapiens Q8TED1 32296183
Intra
HMOX2 P30519 GPX8 Homo sapiens Q8TED1 32296183
Intra
HMOX2 P30519 GPX8 Homo sapiens Q8TED1 32296183
Intra
HMOX2 P30519 KCNJ6 Homo sapiens P48051 32296183
Intra
HMOX2 P30519 KCNJ6 Homo sapiens P48051 32296183
Intra
HMOX2 P30519 KCNJ6 Homo sapiens P48051 32296183
Intra
HMOX2 P30519 STOM Homo sapiens P27105 32296183
Intra
HMOX2 P30519 STOM Homo sapiens P27105 32296183
Intra
HMOX2 P30519 ASGR2 Homo sapiens P07307-3 32296183
Intra
HMOX2 P30519 ASGR2 Homo sapiens P07307-3 32296183
Intra
HMOX2 P30519 AQP6 Homo sapiens Q13520 32296183
Intra
HMOX2 P30519 AQP6 Homo sapiens Q13520 32296183
Intra
HMOX2 P30519 AQP6 Homo sapiens Q13520 32296183
Intra
HMOX2 P30519 GPR152 Homo sapiens Q8TDT2 32296183
Intra
HMOX2 P30519 GPR152 Homo sapiens Q8TDT2 32296183
Intra
HMOX2 P30519 GPR152 Homo sapiens Q8TDT2 32296183
Intra
HMOX2 P30519 ZC2HC1C Homo sapiens Q53FD0-2 32814053
Intra
HMOX2 P30519 ZC2HC1C Homo sapiens Q53FD0-2 32814053
Intra
HMOX2 P30519 ZC2HC1C Homo sapiens Q53FD0-2 32814053
Intra
HMOX2 P30519 LRRC56 Homo sapiens Q8IYG6 32814053
Intra
HMOX2 P30519 LRRC56 Homo sapiens Q8IYG6 32814053
Intra
HMOX2 P30519 LRRC56 Homo sapiens Q8IYG6 32814053
Intra
HMOX2 P30519 CRB3 Homo sapiens Q9BUF7-2 32296183
Intra
HMOX2 P30519 CRB3 Homo sapiens Q9BUF7-2 32296183
Intra
HMOX2 P30519 CRB3 Homo sapiens Q9BUF7-2 32296183
Intra
HMOX2 P30519 SSMEM1 Homo sapiens Q8WWF3 32296183
Intra
HMOX2 P30519 SSMEM1 Homo sapiens Q8WWF3 32296183
Intra
HMOX2 P30519 SSMEM1 Homo sapiens Q8WWF3 32296183
Intra
HMOX2 P30519 C3orf36 Homo sapiens Q3SXR2 32814053
Intra
HMOX2 P30519 C3orf36 Homo sapiens Q3SXR2 32814053
Intra
HMOX2 P30519 C3orf36 Homo sapiens Q3SXR2 32814053
Intra
HMOX2 P30519 FAM209A Homo sapiens Q5JX71 32296183
Intra
HMOX2 P30519 FAM209A Homo sapiens Q5JX71 32296183
Intra
HMOX2 P30519 FAM209A Homo sapiens Q5JX71 32296183
Intra
HMOX2 P30519 RNASEK Homo sapiens Q6P5S7 32296183
Intra
HMOX2 P30519 RNASEK Homo sapiens Q6P5S7 32296183
Intra
HMOX2 P30519 RNASEK Homo sapiens Q6P5S7 32296183
Intra
HMOX2 P30519 ELOVL4 Homo sapiens Q9GZR5 32296183
Intra
HMOX2 P30519 ELOVL4 Homo sapiens Q9GZR5 32296183
Intra
HMOX2 P30519 ELOVL4 Homo sapiens Q9GZR5 32296183
Intra
HMOX2 P30519 GET1 Homo sapiens O00258 32296183
Intra
HMOX2 P30519 GET1 Homo sapiens O00258 32296183
Intra
HMOX2 P30519 FAM210B Homo sapiens Q96KR6 32296183
Intra
HMOX2 P30519 FAM210B Homo sapiens Q96KR6 32296183
Intra
HMOX2 P30519 FAM210B Homo sapiens Q96KR6 32296183
Intra
HMOX2 P30519 UBE2A Homo sapiens P49459 32814053
Intra
HMOX2 P30519 UBE2A Homo sapiens P49459 32814053
Intra
HMOX2 P30519 UBE2A Homo sapiens P49459 32814053
Intra
HMOX2 P30519 NUDT1 Homo sapiens P36639-4 32814053
Intra
HMOX2 P30519 NUDT1 Homo sapiens P36639-4 32814053
Intra
HMOX2 P30519 NUDT1 Homo sapiens P36639-4 32814053
Intra
HMOX2 P30519 MLST8 Homo sapiens A0A0A0MR05 32814053
Intra
HMOX2 P30519 MLST8 Homo sapiens A0A0A0MR05 32814053
Intra
HMOX2 P30519 MLST8 Homo sapiens A0A0A0MR05 32814053
Intra
HMOX2 P30519 MRM1 Homo sapiens Q6IN84-2 32814053
Intra
HMOX2 P30519 MRM1 Homo sapiens Q6IN84-2 32814053
Intra
HMOX2 P30519 MRM1 Homo sapiens Q6IN84-2 32814053
Intra
HMOX2 P30519 CNST Homo sapiens Q6PJW8-3 32814053
Intra
HMOX2 P30519 CNST Homo sapiens Q6PJW8-3 32814053
Intra
HMOX2 P30519 CNST Homo sapiens Q6PJW8-3 32814053
Intra
HMOX2 P30519 LAPTM5 Homo sapiens Q13571 32296183
Intra
HMOX2 P30519 LAPTM5 Homo sapiens Q13571 32296183
Intra
HMOX2 P30519 LAPTM5 Homo sapiens Q13571 32296183
Intra
HMOX2 P30519 EBP Homo sapiens Q15125 32296183
Intra
HMOX2 P30519 EBP Homo sapiens Q15125 32296183
Intra
HMOX2 P30519 EBP Homo sapiens Q15125 32296183
Intra
HMOX2 P30519 SAR1A Homo sapiens Q9NR31 32296183
Intra
HMOX2 P30519 SAR1A Homo sapiens Q9NR31 32296183
Intra
HMOX2 P30519 SAR1A Homo sapiens Q9NR31 32296183
Intra
HMOX2 P30519 POLR2I Homo sapiens P36954 32814053
Intra
HMOX2 P30519 POLR2I Homo sapiens P36954 32814053
Intra
HMOX2 P30519 POLR2I Homo sapiens P36954 32814053
Intra
HMOX2 P30519 ELL2 Homo sapiens O00472 32814053
Intra
HMOX2 P30519 ELL2 Homo sapiens O00472 32814053
Intra
HMOX2 P30519 ELL2 Homo sapiens O00472 32814053
Intra
HMOX2 P30519 CBX4 Homo sapiens O00257-3 32814053
Intra
HMOX2 P30519 CBX4 Homo sapiens O00257-3 32814053
Intra
HMOX2 P30519 CBX4 Homo sapiens O00257-3 32814053
Intra
HMOX2 P30519 FYN Homo sapiens P06241 32814053
Intra
HMOX2 P30519 FYN Homo sapiens P06241 32814053
Intra
HMOX2 P30519 FYN Homo sapiens P06241 32814053
Intra
HMOX2 P30519 SYT1 Homo sapiens P21579 32296183
Intra
HMOX2 P30519 SYT1 Homo sapiens P21579 32296183
Intra
HMOX2 P30519 ARL6IP4 Homo sapiens Q66PJ3-4 32814053
Intra
HMOX2 P30519 ARL6IP4 Homo sapiens Q66PJ3-4 32814053
Intra
HMOX2 P30519 ARL6IP4 Homo sapiens Q66PJ3-4 32814053
Intra
HMOX2 P30519 SNW1 Homo sapiens Q13573 32814053
Intra
HMOX2 P30519 SNW1 Homo sapiens Q13573 32814053
Intra
HMOX2 P30519 SNW1 Homo sapiens Q13573 32814053
Intra
HMOX2 P30519 TMX2 Homo sapiens Q9Y320 32296183
Intra
HMOX2 P30519 TMX2 Homo sapiens Q9Y320 32296183
Intra
HMOX2 P30519 TMX2 Homo sapiens Q9Y320 32296183
Intra
HMOX2 P30519 CIMAP1D Homo sapiens Q3SX64 32814053
Intra
HMOX2 P30519 CIMAP1D Homo sapiens Q3SX64 32814053
Intra
HMOX2 P30519 CIMAP1D Homo sapiens Q3SX64 32814053
Intra
HMOX2 P30519 MGST3 Homo sapiens O14880 32296183
Intra
HMOX2 P30519 MGST3 Homo sapiens O14880 32296183
Intra
HMOX2 P30519 NUP54 Homo sapiens Q7Z3B4 32814053
Intra
HMOX2 P30519 NUP54 Homo sapiens Q7Z3B4 32814053
Intra
HMOX2 P30519 NUP54 Homo sapiens Q7Z3B4 32814053
Intra
HMOX2 P30519 BCL2L13 Homo sapiens Q9BXK5 32296183
Intra
HMOX2 P30519 BCL2L13 Homo sapiens Q9BXK5 32296183
Intra
HMOX2 P30519 BCL2L13 Homo sapiens Q9BXK5 32296183
Intra
HMOX2 P30519 CD79A Homo sapiens P11912 32296183
Intra
HMOX2 P30519 CD79A Homo sapiens P11912 32296183
Intra
HMOX2 P30519 ERGIC3 Homo sapiens Q9Y282 32296183
Intra
HMOX2 P30519 ERGIC3 Homo sapiens Q9Y282 32296183
Intra
HMOX2 P30519 ERGIC3 Homo sapiens Q9Y282 32296183
Intra
HMOX2 P30519 TMEM14B Homo sapiens Q9NUH8 32296183
Intra
HMOX2 P30519 TMEM14B Homo sapiens Q9NUH8 32296183
Intra
HMOX2 P30519 TMEM14B Homo sapiens Q9NUH8 32296183
Intra
HMOX2 P30519 BAAT Homo sapiens Q14032 32814053
Intra
HMOX2 P30519 BAAT Homo sapiens Q14032 32814053
Intra
HMOX2 P30519 BAAT Homo sapiens Q14032 32814053
Intra
HMOX2 P30519 SEMA4G Homo sapiens Q9NTN9-3 32814053
Intra
HMOX2 P30519 SEMA4G Homo sapiens Q9NTN9-3 32814053
Intra
HMOX2 P30519 SEMA4G Homo sapiens Q9NTN9-3 32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HMOX2 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P79126 HO-2/HMOX2 Protein, Human (His) P30519-1 (S2-L291) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Neonatal Jaundice
  • Neonatal Hyperbilirubinemia

  • Neonatal Icterus

  • Jaundice Neonatal

  • Jaundice, Neonatal

  • Hyperbilirubinemia, Neonatal

Gastroparesis
  • Gastroparesis Syndrome

  • Delayed Gastric Emptying

  • Gastric Atonia

  • Gastroparalysis

Hemochromatosis, Type 2b
  • Hemochromatosis Type 2b

  • HFE2B

  • Hemochromatosis 2b

Inflammatory Bowel Disease 30
  • Inflammatory Bowel Disease 30

  • IBD30

Kernicterus
  • Bilirubin Encephalopathy

  • Hyperbilirubinemic Encephalopathy

  • Kernicterus Spectrum Disorder

Porphyria, Acute Intermittent
  • Acute Intermittent Porphyria

  • Porphobilinogen Deaminase Deficiency

  • Pbgd Deficiency

  • AIP

  • Porphyria, Swedish Type

  • Uroporphyrinogen Synthase Deficiency

  • Ups Deficiency

  • Porphyria, Acute Intermittent, Nonerythroid Variant

  • Hydroxymethylbilane Synthase Deficiency

  • Aip - Acute Intermittent Porphyria

  • Porphyria Intermittent Acute

  • Pyrroloporphyria

  • Hmbs Deficiency

  • Porphyria Acute Intermittent

Hirschsprung Disease 1
  • Hirschsprung Disease

  • Aganglionic Megacolon

  • Hscr

  • Hirschsprung'S Disease

  • Congenital Megacolon

  • Congenital Intestinal Aganglionosis

  • Colonic Aganglionosis

  • Hirschsprung Disease, Susceptibility To, 1

  • Hirschsprung Disease, Protection Against

  • HSCR1

  • Mgc

  • Pelvirectal Achalasia

  • Total Intestinal Aganglionosis

  • Megacolon, Aganglionic

  • Macrocolon

  • Hscr 1

  • Hirschsprung Disease Type 1

  • Hirschsprung Disease, Type 1

  • Congenital Dilatation Of Colon

  • Aganglionosis

  • Congenital Aganglionic Megacolon

  • Aganglionosis Of Colon

  • Bowel Aganglionosis

  • Colon Aganglionosis

  • Hirschsprung Megacolon

Renovascular Hypertension
  • Hypertension, Renovascular

  • Hypertension Renovascular

Gilbert Syndrome
  • Gilbert Disease

  • Gilbert'S Disease

  • Gilbert'S Syndrome

  • Cholemia, Familial

  • Familial Nonhemolytic Jaundice

  • Meulengracht Syndrome

  • Gilbert Syndrome, Susceptibility To

  • Hyperbilirubinemia, Gilbert Type

  • Hblrg

  • Hyperbilirubinemia, Arias Type

  • Hyperbilirubinemia I

  • Constitutional Hyperbilirubinemia

  • Gilbert-Meulengracht Syndrome

  • Hereditary Nonhemolytic Jaundice

  • Hyperbilirubinemia Arias Type

  • Hyperbilirubinemia Type 1

  • Constitutional Liver Dysfunction

  • Gilbert-Lereboullet Syndrome

  • Hyperbilirubinemia 1

  • Unconjugated Benign Bilirubinemia

  • GILBS

  • Gilberts Syndrome

  • Familial Nonhaemolytic Jaundice

  • Constitutional Hyperbilirubinaemia

  • Hereditary Nonhaemolytic Bilirubinaemia

  • Familial Nonhaemolytic Bilirubinaemia

  • Idiopathic Hyperbilirubinaemia

  • Icterus Intermittens Juvenilis

  • Chronic Intermittent Juvenile Jaundice

  • Low-Grade Chronic Hyperbilirubinaemia Syndrome

  • Benign Unconjugated Bilirubinaemia Syndrome

  • Hereditary Nonhaemolytic Jaundice

  • Idiopathic Unconjugated Hyperbilirubinaemia

  • Gilbert--Lereboullet Syndrome

  • Constitutional Hepatic Dysfunction

  • Meulengracht Icterus

  • Cholaemia Familiaris Simplex

  • Familial Cholaemia

  • Congenital Familial Cholaemia

  • Physiologic Cholaemia

  • Hyperbilirubinaemia Type 1

  • Gilbert Cholaemia

Bilirubin Metabolic Disorder
  • Hyperbilirubinemia

  • Hereditary Hyperbilirubinemia

  • Hyperbilirubinemia, Hereditary

  • Hyperbilirubinaemia

Deficiency Anemia
  • Anemia

  • Deficiency Anemias

  • Anaemia

Hypertension, Essential
  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration

Alzheimer Disease, Familial, 1
  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta HMOX2 VGNC VGNC:73489
Rattus norvegicus HMOX2 RGD RGD:67402
Mus musculus HMOX2 MGD MGI:109373
Felis catus HMOX2 VGNC VGNC:67599
Bos taurus HMOX2 VGNC VGNC:29886
Canis familiaris HMOX2 VGNC VGNC:41720
Others HMOX2 NCBI