Pikfyve - phosphoinositide kinase, FYVE-type zinc finger containing Gene

Also Known as Pip5k3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 316457

About Pikfyve

Primary_assembly 9: 66,563,727-66,657,868 forward strand.mRatBN7.2:CM026982.1

This gene has 4 transcripts (splice variants), 205 orthologues, 17 paralogues and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 173.2), Spleen (RPKM 145.9) and 9 other tissues.

Summary

Predicted to enable phosphotransferase activity, alcohol group as acceptor and zinc ion binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; phosphatidylinositol metabolic process; and vesicle organization. Predicted to act upstream of or within myelin assembly. Predicted to be located in several cellular components, including cytoplasmic vesicle membrane; membrane raft; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Orthologous to human PIKfyve (phosphoinositide kinase, FYVE-type zinc finger containing). [provided by Alliance of Genome Resources, Apr 2022]

Pikfyve Products (11)

mRNA Protein Name
XM_006245073.2 XP_006245135.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X3
XM_006245077.4 XP_006245139.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4
XM_039084597.1 XP_038940525.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X8
XM_006245076.4 XP_006245138.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4
XM_039084596.1 XP_038940524.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X5
XM_006245071.2 XP_006245133.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1
XM_006245074.4 XP_006245136.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4
XM_006245079.2 XP_006245141.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X7
XM_006245078.2 XP_006245140.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X6
XM_006245072.2 XP_006245134.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X2
XM_039084595.1 XP_038940523.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

Pikfyve Protein Structure

FYVE_PIKfyve_Fab1

FYVE_PIKfyve_Fab1: cd15725 (185 - 246)

DEP_PIKfyve

DEP_PIKfyve: cd04448 (388 - 469)

Fab1_TCP

Fab1_TCP: cd03334 (648 - 908)

PIPKc_PIKfyve

PIPKc_PIKfyve: cd17300 (1848 - 2114)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2129 a.a.
Protein Preferred Names Protein Names

1-phosphatidylinositol-3-phosphate 5-kinase

1-phosphatidylinositol 3-phosphate 5-kinase

  • phosphatidylinositol-3-phosphate 5-kinase type III

  • phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III

  • phosphoinositide kinase, FYVE finger containing

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-14644 Apilimod Inhibitor 99.80% Phase 2

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-118630 Vacuolin-1 Inhibitor 98.54% Unkown
HY-13228 YM-201636 Inhibitor 98.07% Unkown
HY-14644A Apilimod mesylate Inhibitor 99.58% Unkown
HY-15982 APY0201 Inhibitor 99.42% Unkown
HY-119624 MOMIPP Inhibitor 99.00% Unkown
HY-155994 PIK5-12d Degrader 99.15% Unkown
HY-151473 PIKfyve-IN-1 Inhibitor 99.64% Unkown
HY-160477 DC-SX029 Inhibitor 98.07% Unkown
HY-153119 TMX-4153 Degrader 98.96% Unkown
HY-161619 RMC-113 Inhibitor 99.54% Unkown
HY-159625 WX8 Inhibitor 99.43% Unkown
HY-154956 PIKfyve-IN-2 Inhibitor 98.0% Unkown
HY-163943 UNI418 Inhibitor 99.61% Unkown
HY-163133 PIKfyve-IN-3 99.55% Unkown
HY-170909 PIKfyve-IN-4 Inhibitor 99.53% Unkown
HY-123876 AS2677131 Inhibitor / Unkown
HY-177432 TMX-4140 Inhibitor / Unkown
HY-177091 AS2795440 Inhibitor / Unkown
HY-175631 PIKfyve ligand-1 Degrader / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pikfyve NCBI NCBI:200576