2. Gene
  3. ACER2 - alkaline ceramidase 2 Gene

ACER2 - alkaline ceramidase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ASAH3L; ALKCDase2

Gene ID: 340485 | Gene type: protein coding

About ACER2

Cytogenetic location: 9p22.1 Genomic coordinates (GRCh38): 9:19,409,009-19,452,505 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 2 paralogues. Biased expression in stomach (RPKM 29.1), urinary bladder (RPKM 17.8) and 8 other tissues.

Summary

The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The Ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010]

ACER2 Products(1)

mRNA Protein Name
NM_001010887.3 NP_001010887.2 alkaline ceramidase 2

ACER2 Protein Structure

Ceramidase

Ceramidase: Ceramidase (10 - 261)

  • 0
  • 100
  • 200
  • 275 a.a.
Protein Preferred Names Protein Names

alkaline ceramidase 2

alkCDase 2

Related Diseases

Diseases Alias
Farber Lipogranulomatosis

Farber Disease

Acid Ceramidase Deficiency

Ceramidase Deficiency

Ac Deficiency

N-Laurylsphingosine Deacylase Deficiency

Farber'S Disease

FRBRL

Farber'S Lipogranulomatosis

Acylsphingosine Deacylase Deficiency

Farber-Uzman Syndrome

Acy
Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy

Jankovic-Rivera Syndrome

SMAPME

Sma-Pme

Spinal Muscular Atrophy-Progressive Myoclonic Epilepsy Syndrome

Hereditary Myoclonus-Progressive Distal Muscular Atrophy Syndrome

Hereditary Myoclonus With Progressive Distal Muscular Atrophy

Jankovic Rivera Syndrome

Myoclonus, Hereditary, With Progressive Distal Muscular Atrophy

Myoclonus Hereditary Progressive Distal Muscular Atrophy

Atrophy, Muscular, Spinal, With Progressive Myoclonic Epilepsy
Hereditary Sensory And Autonomic Neuropathy Type 1

Hereditary Sensory And Autonomic Neuropathy Type I

Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome

Hsan1e

Hsan1

Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy

Hsn1e

Hsnie

Hereditary Sensory Neuropathy Type Ie

Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome

Hereditary Sensory And Autonomic Neuropathy Type Ie

Hereditary Sensory And Autonomic Neuropathy Type 1e

Hereditary Sensory Neuropathy With Hearing Loss And Dementia

Dnmt1-Complex Disorder

Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss

Hsn Ie

Hereditary Sensory Autonomic Neuropathy, Type 1

Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0260 Methylprednisolone 99.75% Yes
HY-12404 Diminazene aceturate 99.16% Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99346 Regdanvimab Inhibitor 95.00% Unkown
Pre-clinical Phase
Bioactive Molecules (41)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14393 Emodin Inhibitor 99.20% Yes
HY-19414 MLN-4760 Inhibitor 99.93% Unkown
HY-110066 (Z)-Guggulsterone 99.30% Unkown
HY-15275 BMS-265246 Inhibitor 98.92% Unkown
HY-N0639 Punicalin 99.89% Unkown
HY-122445 Resorcinolnaphthalein Activator 99.87% Unkown
HY-P2536 Mca-Ala-Pro-Lys(Dnp)-OH 99.80% Unkown
HY-P2222A DX600 TFA Inhibitor 99.94% Unkown
HY-B0260R Methylprednisolone (Standard) 99.67% Unkown
HY-P2222 DX600 Inhibitor / Unkown
HY-138067 SSAA09E2 Inhibitor 98.17% Unkown
HY-126419 Kobophenol A Inhibitor 99.90% Unkown
HY-19414A (R)-MLN-4760 Inhibitor 99.51% Unkown
HY-D1270 Direct Violet 1 Inhibitor / Unkown
HY-B0260S3 Methylprednisolone-d7 ≥99.0% Unkown
HY-P2616A Mca-YVADAP-Lys(Dnp)-OH TFA Chemical 98.85% Unkown
HY-RS00001 ACE2 Rat Pre-designed siRNA Set A Inhibitor / Unkown
HY-100450 BML-111 ≥98.0% Unkown
HY-113478S Ursodeoxycholic acid-2,2,4,4-d4 99.52% Unkown
HY-P3141 STIEEQAKTFLDKFNHEAEDLFYQSSLASWN 95.28% Unkown
HY-P3142 NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ 96.51% Unkown
HY-14393S Emodin-d4 Inhibitor / Unkown
HY-14393R Emodin (Standard) Inhibitor / Unkown
HY-149373 Garcinone B Inhibitor / Unkown
HY-149767 CMX990 Inhibitor / Unkown
HY-156441 SARS-CoV-2-IN-65 Inhibitor / Unkown
HY-156862 (+)-Chloroquine / Unkown
HY-157966 SARS-CoV-2 3CLpro-IN-23 Inhibitor / Unkown
HY-158073 ML2006a4 Inhibitor / Unkown
HY-161261 SARS-CoV-2-IN-81 Inhibitor / Unkown
HY-B0260S Methylprednisolone-d3 / Unkown
HY-B0260S2 Methylprednisolone-d4 / Unkown
HY-B0260S4 Methylprednisolone-d2 / Unkown
HY-P2616 Mca-YVADAP-Lys(Dnp)-OH Chemical / Unkown
HY-P3258 SP-10 / Unkown
HY-P4546 Abz-Ser-Pro-3-nitro-Tyr / Unkown
HY-RS00152 ACE2 Human Pre-designed siRNA Set A / Unkown
HY-RS00154 ACER2 Human Pre-designed siRNA Set A / Unkown
HY-157154 MAT-POS-e194df51-1 Inhibitor / Unkown
HY-161070 Antiviral agent 46 Inhibitor / Unkown
HY-P5827 SBP1 peptide / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9801 Anti-Spike-RBD mAb / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ACER2 VGNC VGNC:59507
Rattus norvegicus ACER2 RGD RGD:1304629
Canis familiaris ACER2 VGNC VGNC:37505
Bos taurus ACER2 VGNC VGNC:25537
Mus musculus ACER2 MGD MGI:1920932
Macaca mulatta ACER2 VGNC VGNC:103235