2. Anti-infection Metabolic Enzyme/Protease
  3. SARS-CoV Angiotensin-converting Enzyme (ACE)
  4. Regdanvimab

Regdanvimab  (Synonyms: CT-P59)

Cat. No.: HY-P99346 Purity: 95.00%
COA

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Regdanvimab (CT-P59) is a human monoclonal antibody that targets the receptor-binding domain of SARS-CoV-2 spike protein, blocking interaction with ACE2 for viral entry. Regdanvimab can be used for the research of COVID-19.

For research use only. We do not sell to patients.

Regdanvimab Chemical Structure

Regdanvimab Chemical Structure

CAS No. : 2444308-95-4

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5 mg USD 680 In-stock
10 mg USD 1080 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Regdanvimab (CT-P59) is a human monoclonal antibody that targets the receptor-binding domain of SARS-CoV-2 spike protein, blocking interaction with ACE2 for viral entry. Regdanvimab can be used for the research of COVID-19[1].

IC50 & Target

SARS-CoV-2, ACE2[1]
In Vitro

Regdanvimab (CT-P59) (0-1000 ng/mL; 72 h) can neutralize Gamma, Delta and Epsilon variants with IC50s of 161.5-1237 ng/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Regdanvimab Related Antibodies
In Vivo

Regdanvimab (CT-P59) (5-80 mg/kg; i.p.; single dose) has an ability to lower viral burden against Gamma and Delta variants in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: hACE2 transgenic (TG) mice inoculated with Gamma or Delta variant[1]
Dosage: 5, 20, 40, and 80 mg/kg
Administration: Intraperitoneal injection, 8 h post-inoculation, single dose
Result: Delayed body weight loss and showed a statistically significant difference compared to the placebo group. Prevented the weight loss of the mice infected with Delta variant. Significantly inhibited the virus replication in the respiratory tract.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Regdanvimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 95.00%

COA (231 KB)

Handling Instructions (2659 KB)
References
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Regdanvimab Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Regdanvimab2444308-95-4CT-P59SARS-CoVAngiotensin-converting Enzyme (ACE)SARS coronavirusCOVID-19Gamma variantDelta variantEpsilon variantInhibitorinhibitorinhibit

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