1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. (R)-MLN-4760

(R)-MLN-4760 

Cat. No.: HY-19414A
Handling Instructions

(R)-MLN-4760, the R-enantiomer of MLN-4760, is a potent and selective ACE2 inhibitor, with an IC50 of 0.44 nM for human ACE2. (R)-MLN-4760 shows more than 5000-fold selectivity for ACE2 over ACE (IC50>100 μM) and CPDA (IC50=27 μM).

For research use only. We do not sell to patients.

(R)-MLN-4760 Chemical Structure

(R)-MLN-4760 Chemical Structure

CAS No. : 305335-29-9

Size Price Stock Quantity
1 mg USD 200 In-stock
Estimated Time of Arrival: December 31
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 800 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (R)-MLN-4760:

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Description

(R)-MLN-4760, the R-enantiomer of MLN-4760, is a potent and selective ACE2 inhibitor, with an IC50 of 0.44 nM for human ACE2. (R)-MLN-4760 shows more than 5000-fold selectivity for ACE2 over ACE (IC50>100 μM) and CPDA (IC50=27 μM)[1].

IC50 & Target

IC50: 0.44 nM (human ACE2)[1]

In Vitro

(R)-MLN-4760 shows more than 5000-fold selectivity for human ACE2 over human testicular ACE (IC50>100 μM) and Bovine CPDA (IC50=27 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

428.31

Formula

C₁₉H₂₃Cl₂N₃O₄

CAS No.
SMILES

O=C(O)[[email protected]](CC1=CN=CN1CC2=CC(Cl)=CC(Cl)=C2)N[[email protected]@H](C(O)=O)CC(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (33.36 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3348 mL 11.6738 mL 23.3476 mL
5 mM 0.4670 mL 2.3348 mL 4.6695 mL
10 mM 0.2335 mL 1.1674 mL 2.3348 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

(R)-MLN-4760Angiotensin-converting Enzyme (ACE)ACE2ACECPDAInhibitorinhibitorinhibit

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(R)-MLN-4760
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