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Cat. No.: HY-105801

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Lydimycin

Name: Lydimycin
Brand: MedChemExpress
SKU: HY-105801
Availability: PreOrder

(Synonyms: α-DHB; α-Dehydrobiotin)

Lydimycin (α-DHB; α-Dehydrobiotin) is an antibiotic produced by Streptomyces lydicus, with antibacterial, antifungal and antiviral activities. Lydimycin inhibits the binding of SARS-CoV-2 S-614G spike protein to human ACE2. The antibacterial activity of Lydimycin can be reversed by Biotin (HY-B0511) in the culture medium. Lydimycin is applicable to infection-related research.

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CAS No.: 10118-85-1
Formule: C₁₀H₁₄N₂O₃S
Masse moléculaire:242.29

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Please store the product under the recommended conditions in the Certificate of Analysis.

Lydimycin Chemical Structure

CAS No.: 10118-85-1

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Description

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Bacterial^[1]

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In Vitro

Lydimycin (compound Ⅰ) displays broad-spectrum in vitro antimicrobial activity against diverse gram-positive bacteria, gram-negative bacteria, and fungi^[1].
Lydimycin (1.25-20.0 μg) inhibits Escherichia coli growth in a synthetic medium in a dose-dependent manner, with its antibacterial activity reversed by increasing concentrations of biotin, showing no inhibition at 0.100 μg/mL Biotin (HY-B0511) across all tested doses^[1].
Lydimycin (0-200 μM) inhibits the binding of SARS-CoV-2 S-614G-Strep spike protein to human ACE2-Fc with an IC₅₀ of 1.6 μM, without non-specific Alpha signal interference^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 10118-85-1
Masse moléculaire 242.29
Formule C₁₀H₁₄N₂O₃S
SMILES

C(C/C=C/C(O)=O)[C@H]1[C@@]2([C@@](NC(=O)N2)(CS1)[H])[H]
Synonyms

α-DHB; α-Dehydrobiotin
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Microorganisms
Streptomyces lydicus
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Hanka L J, et al. Naturally Occurring Antimetabolite Antibiotic Related to Biotin. Science, 1966, 154(3757): 1667-1668.

[2]. Sammons RM, et al. High-Throughput Assay for Identifying Diverse Antagonists of the Binding Interaction between the ACE2 Receptor and the Dynamic Spike Proteins of SARS-CoV-2. ACS infectious diseases. 2022 Nov 11;8(11):2259-2270. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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