IGFBP7 - insulin like growth factor binding protein 7 Gene

Also Known as AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3490

About IGFBP7

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:57,030,773-57,110,385 (from NCBI)

This gene has 3 transcripts (splice variants), 183 orthologues, 2 paralogues and is associated with 3 phenotypes. Broad expression in kidney (RPKM 607.4), gall bladder (RPKM 382.6) and 21 other tissues.

Summary

This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

IGFBP7 Products (2)

mRNA Protein Name
NM_001253835.2 NP_001240764.1 insulin-like growth factor-binding protein 7 isoform 2 precursor
NM_001553.3 NP_001544.1 insulin-like growth factor-binding protein 7 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9388210 GOA
enables receptor ligand activity IDA
IDA: Inferred from direct assay
38218180 GOA
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IDA
IDA: Inferred from direct assay
38218180 GOA
involved in cell adhesion IDA
IDA: Inferred from direct assay
8117260 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGFBP7 Protein Structure

IGFBP

IGFBP: Insulin-like growth factor binding protein (32 - 87)

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (116 - 156)

I-set

I-set: Immunoglobulin I-set domain (160 - 265)

  • 0
  • 100
  • 200
  • 282 a.a.
Protein Preferred Names Protein Names

insulin-like growth factor-binding protein 7

  • IGF-binding protein 7

Recombinant IGFBP7 Proteins

Cat. No. Product Name Accession Purity
HY-P70726 IGFBP-7 Protein, Human (HEK293, His) Q16270-1 (S27-L282) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73142 IGFBP-7 Protein, Human (HEK293, Fc) Q16270-1 (S27-L282) ≥ 95%, as determined by Bis-Tris PAGE.

IGFBP7 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83334 IGFBP7 Antibody (YA3079) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat
HY-P83334A IGFBP7 Antibody (YA3079)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis

  • Familial Retinal Arterial Macroaneurysm

  • RAMSVPS

  • Fram

  • Retinal Arterial Macroaneurysm And Supravalvular Pulmonic Stenosis

  • Macroaneurysm, Arterial, Retinal, With Supravalvular Pulmonic Stenosis
Diabetic Angiopathy

  • Diabetic Angiopathies

  • Diabetic Peripheral Angiopathy

  • Diabetic Vascular Disorder
Pulmonic Stenosis

  • Valvular Pulmonic Stenosis

  • Congenital Pulmonary Valvar Stenosis

  • Congenital Stenosis Of Pulmonary Valve

  • Pulmonary Valve Stenosis

  • Pulmonary Stenosis

  • Congenital Pulmonary Valve Stricture

  • Congenital Pulmonary Valve Stenosis
Spinocerebellar Ataxia, Autosomal Recessive 12

  • Autosomal Recessive Spinocerebellar Ataxia 12

  • SCAR12

  • Spinocerebellar Ataxia With Mental Retardation And Epilepsy

  • Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Wwox Deficiency

  • Autosomal Recessive Spinocerebellar Ataxia Type 12

  • Spinocerebellar Ataxia, Autosomal Recessive, 12

  • Ataxia, Spinocerebellar, Autosomal Recessive, Type 12
Viral Laryngitis
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Bladder Cancer

  • Urinary Bladder Cancer

  • Bladder Carcinoma

  • Urinary Bladder Carcinoma

  • Bladder Neoplasm

  • Bladder Tumor

  • Cancer, Bladder

  • Malignant Neoplasm Of Urinary Bladder

  • Carcinoma Of Bladder

  • Bladder Cancer, Somatic

  • Tumor Of The Bladder

  • Carcinoma Of Urinary Bladder

  • Bladder Carcinoma Urinary

  • Cancer Of The Urinary Bladder

  • Cancer, Urinary Bladder

  • Malignant Bladder Neoplasm

  • Malignant Bladder Tumor

  • Neoplasm Of The Bladder

  • Neoplasm Of The Urinary Bladder

  • Tumor Of The Urinary Bladder

  • Urinary Bladder Neoplasm

  • BLC

  • Urothelial Carcinoma Of The Bladder

  • Bladder Tumors

  • Urinary Bladder Neoplasms

  • Bladder Cancer Nos

  • Vesical Cancer Nos

  • Malignant Neoplasm Of Bladder, Part Unspecified

  • Malignant Tumour Of Urinary Bladder

  • Primary Malignant Neoplasm Of Bladder
Anuria

  • Suppression Of Urinary Secretion
Acute Kidney Tubular Necrosis

  • Acute Tubular Necrosis

  • Acute Renal Failure With Tubular Necrosis

  • Acute Tubule Necrosis

  • Acute Renal Failure With Lesion Of Tubular Necrosis

  • Atn - Acute Tubular Necrosis

  • Tubular Necrosis Acute

  • Kidney Tubular Necrosis, Acute

  • Acute Renal Tubular Necrosis

  • Acute Tubular Nephrosis

  • Ischaemic Acute Tubular Necrosis

  • Ischaemic Tubular Necrosis

  • Kidney Tubular Necrosis

  • Lower Nephron Nephrosis

  • Necrotising Renal Oedema

  • Renal Tubular Necrosis

  • Toxic Tubular Necrosis

  • Tubular Kidney Necrosis

  • Tubular Necrosis Nos

  • Tubular Nephrosis
Prader-Willi Syndrome

  • Prader-Labhart-Willi Syndrome

  • PWS

  • Willi-Prader Syndrome

  • Prader-Willi Syndrome Due To Translocation

  • Prader-Willi Syndrome Due To Imprinting Mutation

  • Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

  • Prader Willi Syndrome

  • Upd(15)Mat
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diabetes Mellitus

  • Diabetes
Meningioma, Familial

  • Meningioma

  • Familial Meningioma

  • Meningioma, Familial, Susceptibility To

  • Meningeal Neoplasm

  • Meningeal Neoplasms

  • Meningiomas

  • Meningioma, Nf2-Related, Somatic

  • Meningioma, Sis-Related

  • Meningothelial Cell Tumor

  • Neoplasm Of The Meninges

  • Primary Meningeal Tumor

  • Familial Multiple Meningioma

  • MNGMA

  • Meningioma, Benign, No Icd-O Subtype

  • Intracranial Meningioma

  • Meningothelial Cell Neoplasm

  • Supratentorial Meningioma

  • Primary Neoplasm Of Spinal Meninges

  • Benign Intracranial Meningioma

  • Benign Meningioma

  • Meningeal Tumours

  • Meningeal Sarcoma Of Unspecified Site

  • Meningothelial Sarcoma Of Unspecified Site
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N1990 Gypenoside XLIX 99.88% Unkown
HY-RS06630 IGFBP7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17134 Igfbp7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23580 Igfbp7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta IGFBP7 VGNC VGNC:73578
Canis familiaris IGFBP7 VGNC VGNC:41908
Rattus norvegicus IGFBP7 RGD RGD:1306201
Bos taurus IGFBP7 VGNC VGNC:30089
Mus musculus IGFBP7 MGD MGI:1352480
Felis catus IGFBP7 VGNC VGNC:78514
Others IGFBP7 NCBI