IGFBP7 - insulin like growth factor binding protein 7 Gene

Homo sapiens

Also known as AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1

Gene ID: 3490 | Gene type: protein coding

About IGFBP7

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:57,030,773-57,110,385 (from NCBI)

This gene has 3 transcripts (splice variants), 183 orthologues, 2 paralogues and is associated with 3 phenotypes. Broad expression in kidney (RPKM 607.4), gall bladder (RPKM 382.6) and 21 other tissues.

Summary

This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

IGFBP7 Products(2)

mRNA	Protein	Name
NM_001253835.2	NP_001240764.1	insulin-like growth factor-binding protein 7 isoform 2 precursor
NM_001553.3	NP_001544.1	insulin-like growth factor-binding protein 7 isoform 1 precursor

IGFBP7 Protein Structure

IGFBP

Kazal_2

I-set

0
100
200
282 a.a.

Protein Preferred Names

Protein Names

insulin-like growth factor-binding protein 7

IGF-binding protein 7

Recombinant IGFBP7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70726	IGFBP-7 Protein, Human (HEK293, His)	Q16270 (S27-L282)	≥95%
HY-P73142	IGFBP-7 Protein, Human (HEK293, Fc)	Q16270 (S27-L282)	≥95%

Related Diseases

Diseases

Alias

Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis

Familial Retinal Arterial Macroaneurysm	RAMSVPS
Fram	Retinal Arterial Macroaneurysm And Supravalvular Pulmonic Stenosis
Macroaneurysm, Arterial, Retinal, With Supravalvular Pulmonic Stenosis

Diabetic Angiopathy

Diabetic Angiopathies	Diabetic Peripheral Angiopathy
Diabetic Vascular Disorder

Pulmonic Stenosis

Valvular Pulmonic Stenosis	Congenital Pulmonary Valvar Stenosis
Congenital Stenosis Of Pulmonary Valve	Pulmonary Valve Stenosis
Pulmonary Stenosis	Congenital Pulmonary Valve Stricture
Congenital Pulmonary Valve Stenosis

Spinocerebellar Ataxia, Autosomal Recessive 12

Autosomal Recessive Spinocerebellar Ataxia 12	SCAR12
Spinocerebellar Ataxia With Mental Retardation And Epilepsy	Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Wwox Deficiency
Autosomal Recessive Spinocerebellar Ataxia Type 12	Spinocerebellar Ataxia, Autosomal Recessive, 12
Ataxia, Spinocerebellar, Autosomal Recessive, Type 12

Viral Laryngitis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Anuria

Suppression Of Urinary Secretion

Acute Kidney Tubular Necrosis

Acute Tubular Necrosis	Acute Renal Failure With Tubular Necrosis
Acute Tubule Necrosis	Acute Renal Failure With Lesion Of Tubular Necrosis
Atn - Acute Tubular Necrosis	Tubular Necrosis Acute
Kidney Tubular Necrosis, Acute	Acute Renal Tubular Necrosis
Acute Tubular Nephrosis	Ischaemic Acute Tubular Necrosis
Ischaemic Tubular Necrosis	Kidney Tubular Necrosis
Lower Nephron Nephrosis	Necrotising Renal Oedema
Renal Tubular Necrosis	Toxic Tubular Necrosis
Tubular Kidney Necrosis	Tubular Necrosis Nos
Tubular Nephrosis

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diabetes Mellitus

Diabetes

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06630	IGFBP7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IGFBP7	VGNC	VGNC:73578
Canis familiaris	IGFBP7	VGNC	VGNC:41908
Rattus norvegicus	IGFBP7	RGD	RGD:1306201
Bos taurus	IGFBP7	VGNC	VGNC:30089
Mus musculus	IGFBP7	MGD	MGI:1352480
Felis catus	IGFBP7	VGNC	VGNC:78514
Others	IGFBP7	NCBI

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