MRC1 - mannose receptor C-type 1 Gene

Also Known as MMR; hMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4360

About MRC1

Cytogenetic location: 10p12.33 Genomic coordinates (GRCh38): 10:17,809,348-17,911,164 (from NCBI)

This gene has 1 transcript (splice variant), 423 orthologues and 4 paralogues. Broad expression in lung (RPKM 50.7), spleen (RPKM 28.0) and 19 other tissues.

Summary

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]

MRC1 Products (1)

mRNA Protein Name
NM_002438.4 NP_002429.1 macrophage mannose receptor 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cargo receptor activity IDA
IDA: Inferred from direct assay
20035344 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11222859 GOA
Biological Process GO Annotation Evidence References Source
involved in receptor-mediated endocytosis IDA
IDA: Inferred from direct assay
20035344 GOA
Cellular Component GO Annotation Evidence References Source
located in endosome membrane IDA
IDA: Inferred from direct assay
20035344 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
20035344 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRC1 Protein Structure

Ricin_B_lectin

Ricin_B_lectin: Ricin-type beta-trefoil lectin domain (27 - 105)

fn2

fn2: Fibronectin type II domain (168 - 209)

Lectin_C

Lectin_C: Lectin C-type domain (237 - 342)

Lectin_C

Lectin_C: Lectin C-type domain (384 - 488)

Lectin_C

Lectin_C: Lectin C-type domain (523 - 626)

Lectin_C

Lectin_C: Lectin C-type domain (669 - 778)

Lectin_C

Lectin_C: Lectin C-type domain (817 - 924)

Lectin_C

Lectin_C: Lectin C-type domain (966 - 1081)

Lectin_C

Lectin_C: Lectin C-type domain (1115 - 1214)

Lectin_C

Lectin_C: Lectin C-type domain (1254 - 1357)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1456 a.a.
Protein Preferred Names Protein Names

macrophage mannose receptor 1

  • C-type lectin domain family 13 member D

Recombinant MRC1 Proteins

Cat. No. Product Name Accession Purity
HY-P78736 CD206/MMR Protein, Human (HEK293, His) P22897-1 (L19-A1389) ≥ 95%, as determined by Bis-Tris PAGE.

MRC1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81214 Macrophage mannose receptor 1 Antibody (YA3531) WB Human, Rat
HY-P81214A Macrophage mannose receptor 1 Antibody (YA3531)(PBS only) WB Human, Rat
HY-P84194 Macrophage mannose receptor 1 Antibody (YA3891) ICC/IF, FC Human, Mouse, Rat
HY-P84194A Macrophage mannose receptor 1 Antibody (YA3891)(PBS only) ICC/IF, FC Human, Mouse, Rat
HY-P84195 Macrophage mannose receptor 1 Antibody (YA3892) IHC-P, FC Human
HY-P84195A Macrophage mannose receptor 1 Antibody (YA3892)(PBS only) IHC-P, FC Human
HY-P84974 Macrophage mannose receptor 1 Antibody (YA4666) ELISA Human
HY-P86350 Macrophage mannose receptor 1 Antibody (YA6042) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Dengue Virus

  • Dengue Virus, Susceptibility To

  • Dengue Fever, Protection Against

  • Dengue Fever
Gaucher'S Disease

  • Gaucher Disease

  • Kerasin Thesaurismosis

  • Glucocerebrosidase Deficiency

  • Glucosylceramidase Deficiency

  • Cerebroside Lipidosis Syndrome

  • Acid Beta-Glucosidase Deficiency

  • Glucosylceramide Beta-Glucosidase Deficiency

  • Acute Cerebral Gaucher Disease

  • Gaucher Splenomegaly

  • Glucocerebrosidosis

  • Glucosyl Cerebroside Lipidosis

  • Kerasin Lipoidosis

  • Lipoid Histiocytosis

  • Glocucerebrosidase Deficiency

  • Sphingolipidosis 1

  • Gaucher Syndrome

  • Gauchers Disease

  • Gd

  • Glucosylceramide Lipidosis

  • Kerasin Histiocytosis

  • Gaucher Disease, Type 1

  • Gaucher Disease, Type 2
Hepatitis B

  • Chronic Hepatitis B

  • Hepatitis B Infection

  • Serum Hepatitis

  • HBV

  • Hepatitis B Chronic

  • Hbv, Susceptibility To

  • Hepatitis B, Chronic

  • Chronic Hepatitis B Without Delta Agent

  • Chronic Hbv - [Hepatitis B Virus] Infection

  • Hepatitis B Nos

  • Chronic Type B Viral Hepatitis

  • Hep B Nos
Hepatitis

  • Chronic Hepatitis

  • Chronic Persistent Hepatitis

  • Acute Hepatitis

  • Hepatitis, Chronic

  • Acute And Subacute Liver Necrosis

  • Acute/Subac. Necrosis Of Liver

  • Animal Hepatitis

  • Hepatitis Chronic

  • Hepatitis A

  • Hepatitis, Animal

  • Hepatitis Due To Toxoplasmosis

  • Hepatitis In Toxoplasmosis

  • Toxoplasmal Hepatitis

  • Chronic Hepatitis, Unspecified

  • Chronic Active Hepatitis Nec

  • Other Specified Chronic Hepatitis

  • Chronic Persistent Hepatitis Nec

  • Chronic Lobular Hepatitis Nec
Gastroparesis

  • Gastroparesis Syndrome

  • Delayed Gastric Emptying

  • Gastric Atonia

  • Gastroparalysis
Mycobacterium Tuberculosis 1

  • Tuberculosis

  • Tuberculoma

  • Tuberculosis, Susceptibility To

  • Mycobacterium Tuberculosis, Susceptibility To, 1

  • Mtbs1

  • TB
Tenosynovial Giant Cell Tumor

  • Fibrous Histiocytoma Of Tendon Sheath

  • Giant Cell Tumor Of Tendon Sheath

  • Giant Cell Tumor Of Tenosynovium

  • Giant Cell Tumour Of Tendon Sheath

  • Giant Cell Tumour Of Tenosynovium

  • Tenosynovial Giant Cell Tumour

  • Diffuse-Type Gct

  • Diffuse-Type Giant Cell Tumor

  • Pigmented Villonodular Synovitis

  • Tgct

  • Tsgct
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Interstitial Lung Disease 2

  • Idiopathic Pulmonary Fibrosis

  • Ipf

  • Fibrocystic Pulmonary Dysplasia

  • Pulmonary Fibrosis, Idiopathic

  • Pulmonary Fibrosis, Idiopathic, Susceptibility To

  • Cryptogenic Fibrosing Alveolitis

  • ILD2

  • Idiopathic Pulmonary Fibrosis, Familial

  • Fibrosing Alveolitis, Cryptogenic

  • Uip

  • Fibrosing Alveolitis

  • Interstitial Pneumonitis, Usual

  • Familial Idiopathic Pulmonary Fibrosis

  • Idiopathic Fibrosing Alveolitis, Chronic Form

  • Usual Interstitial Pneumonia

  • Fibrosing Alveolitis Cryptogenic

  • Hamman-Rich Disease

  • Idiopathic Pulmonary Fibrosis Familial

  • Interstitial Pneumonitis Usual

  • Fibrosis Idiopathic Pulmonary

  • Fibrosis, Pulmonary, Idiopathic

  • Hamman-Rich Syndrome

  • Chronic Idiopathic Pulmonary Fibrosis

  • Acute Interstitial Pneumonia

  • Interstitial Pulmonary Fibrosis

  • Ipf - [Idiopathic Pulmonary Fibrosis]

  • Idiopathic Lung Fibrosis

  • Fibrosing Lung Disease

  • Pulmonary Fibrosis Nos

  • Fibrosing Pneumonitis
Nervous System Disease

  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10894 mUNO 97.50% Unkown
HY-107509 LY2389575 hydrochloride Modulator 99.93% Unkown
HY-169859 EP4 receptor antagonist 7 Antagonist 99.9% Unkown
HY-P11462 UNO peptide Ligand / Unkown
HY-RS08641 MRC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19618 Mrc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26113 Mrc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MRC1 VGNC VGNC:31598
Felis catus MRC1 VGNC VGNC:68315
Rattus norvegicus MRC1 RGD RGD:1309353
Mus musculus MRC1 MGD MGI:97142
Macaca mulatta MRC1 VGNC VGNC:74925
Canis familiaris MRC1 VGNC VGNC:43359
Others MRC1 NCBI