TOP1 - DNA topoisomerase I Gene

Also Known as TOP

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 477229

About TOP1

Primary_assembly 24: 29,781,498-29,872,296 forward strand.ROS_Cfam_1.0:CM025123.1

This gene has 1 transcript (splice variant) and 273 orthologues.

TOP1 Products (1)

mRNA Protein Name
XM_038433832.1 XP_038289760.1 DNA topoisomerase 1

TOP1 Protein Structure

Topoisomer_IB_N_htopoI_like

Topoisomer_IB_N_htopoI_like: cd03488 (220 - 434)

TOPEUc

TOPEUc: smart00435 (364 - 741)

  • 0
  • 200
  • 400
  • 600
  • 770 a.a.
Protein Preferred Names Protein Names

DNA topoisomerase 1

  • topoisomerase (DNA) I

  • topoisomerase I

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16560 Camptothecin 99.77% Unkown

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-164734 Raludotatug Deruxtecan 99.29% Phase 3
HY-171689 Puxitatug samrotecan Inhibitor 98.51% Phase 2
HY-168739 Topoisomerase I inhibitor 17 / Phase 2
HY-171124 Tilatamig samrotecan Inhibitor 95.26% Phase 1
HY-U00248 LMP744 Inhibitor 98.33% Phase 1
HY-18350 Indimitecan Inhibitor 98.30% Phase 1
HY-U00248A LMP744 hydrochloride Inhibitor 99.08% Phase 1

Pre-clinical Phase

Bioactive Molecules (30)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148819A NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride Inhibitor 98.46% Unkown
HY-148819 NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT Inhibitor 98.71% Unkown
HY-163099 P5(PEG24)-VC-PAB-Exatecan 99.74% Unkown
HY-153278 Q901 Inhibitor 98.38% Unkown
HY-153278A Q901 TFA Inhibitor / Unkown
HY-160005 LMP517 Inhibitor 99.58% Unkown
HY-175203 Topi MF-6 Inhibitor 99.79% Unkown
HY-W008874 meso-Tetra(4-pyridyl)porphine Inhibitor ≥97.0% Unkown
HY-N0114A (±)-Evodiamine 99.74% Unkown
HY-126142 Top1 inhibitor 1 Inhibitor 99.67% Unkown
HY-RS14893 TOP1MT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-118942 Topovale Inhibitor 99.94% Unkown
HY-143265 Topoisomerase I inhibitor 2 / Unkown
HY-144794 EGFR-IN-46 / Unkown
HY-146437 Topoisomerase I inhibitor 6 Inhibitor / Unkown
HY-149348 DiPT-4 / Unkown
HY-159935 Top1-IN-2 Inhibitor / Unkown
HY-161957 Top1/2-IN-1 Inhibitor / Unkown
HY-16560B (R)-Camptothecin Control / Unkown
HY-178036 ZM484 Inhibitor / Unkown
HY-180555 SN38-(PEG)2-Pom-α Activator / Unkown
HY-181080 TOP1/TDP1-IN-1 / Unkown
HY-18350A Indimitecan hydrochloride Inhibitor / Unkown
HY-184245 Hsp90-IN-48 Inhibitor / Unkown
HY-N15249 4"-Isovalerylspiramycin I / Unkown
HY-RS14890 TOP1 Human Pre-designed siRNA Set A / Unkown
HY-RS14891 Top1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS14892 Top1 Rat Pre-designed siRNA Set A / Unkown
HY-W654323 PNU-142586 sodium Inhibitor / Unkown
HY-133219 Guajadial C Inhibitor / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990947 Tilatamig Inhibitor 99.99% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens TOP1 NCBI NCBI:7150