Torvutatug
Based on 1 Customer Validation
Torvutatug (AZD5335 Antibody) is a human IgG1 κ monoclonal antibody against FRα, with an IC50 value of 7.4 nM against hFRα. Torvutatug can serve as an ADC antibody for the synthesis of ADC, such as AZD5335. Torvutatug is applicable to ovarian cancer-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.00%
- CAS 番号: 2975630-15-8
- 分子量:145.532 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
FRα 7.4 nM (IC50) |
体外実験
Torvutatug binds specifically to cynomolgus monkey FRα, and shows no cross-reactivity with non-target folate receptor paralogs or rodent FRα[1].
Torvutatug exhibits similarly high affinity for cynomolgus monkey FRα, but extremely low affinity for mouse FRα[1].
Torvutatug binds to cell-surface FRα with high specificity, and exhibits negligible off-target binding to DLL1 only at extremely high concentrations[1].
Torvutatug (up to 8 h) is rapidly internalized and trafficked to lysosomes in FRα-expressing KB cells, and its internalization level is significantly higher than that of the isotype control antibody[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
遺伝子ID
アクセッション番号
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IgG1-kappa
アプリケーション
ELISA, FACS, Functional assay
Verified Bioactivity
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Loaded Torvutatug on ProA biosensor, can bind HY-P70296 FOLR1 Protein, Human (HEK293, His) with an affinity constant of 2.582E-08 M as determined in BLI assay.
化学情報
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CAS 番号 2975630-15-8
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性状 Liquid
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分子量 145.532 kDa
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Color Colorless to light yellow
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SMILES
[Torvutatug]
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別名
AZD5335 Antibody; INT-019
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
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データシート (258 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
[1]. Zoeller JJ, et al. Derivation of AZD5335, a Novel FRα-Targeted TOP1i-Loaded ADC, for the Treatment of FRα-Expressing Cancers. Clinical cancer research : an official journal of the American Association for Cancer Research. 2025 Dec 15;31(24):5261-5275. [Content Brief]
[3]. Moore KN, et al. Antibody-drug conjugates in gynaecological cancers: opportunities and challenges. Nat Rev Clin Oncol. 2026 Jun 17. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Torvutatug 関連分類
HY-P991164 関連分類
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