Antibody-drug conjugates in gynaecological cancers: opportunities and challenges
- Nat Rev Clin Oncol. 2026 Jun 17. doi: 10.1038/s41571-026-01164-9.
- 1. Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. [email protected].
- 2. Department of Medicine, Mass General Brigham Cancer Institute, Boston, MA, USA.
- 3. Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
- 4. Department of Medicine, Brown University Health, Providence, RI, USA.
- 5. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. [email protected].
Antibody-drug conjugates (ADCs) have transformed the Cancer therapeutic landscape over the past two decades, profoundly shaping treatment outcomes across a wide array of indications. Three ADCs are currently approved for previously treated gynaecological cancers: mirvetuximab soravtansine for folate receptor-α-positive ovarian Cancer, trastuzumab deruxtecan for solid tumours expressing HER2 (defined as a staining intensity on immunohistochemistry of 3+) and tisotumab vedotin for cervical Cancer (independent of tissue factor expression). Current research priorities include identifying novel targets, better understanding mechanisms of resistance and Sequencing strategies, and optimal management of the toxicities of ADCs. Moreover, rational combinations could reinforce and extend the clinical potential of these agents, as has already been demonstrated with the addition of ADCs to immune checkpoint inhibitors in an effort to amplify antitumour immunity and prolong the durability of clinical responses. In this Review, we provide an overview of the current landscape of ADCs in gynaecological malignancies, highlighting key advances and future opportunities.