2. PROTAC Immunology/Inflammation
  3. PROTACs STING
  4. SN38-(PEG)2-Pom-α

SN38-(PEG)2-Pom-α is a selective PROTAC RPL15 degrader. SN38-(PEG)2-Pom-α induces ubiquitin-mediated degradation of RPL15 without affecting TOP1. SN38-(PEG)2-Pom-α induces damage-associated molecular pattern (DAMP) secretion from cancer cells, which activated cGAS-STING signaling in dendritic cells. SN38-(PEG)2-Pom-α enhances anti-PD-1 immunotherapy in a murine melanoma tumor model expressing human CRBN. SN38-(PEG)2-Pom-α can be used for melanoma research.
(Pink: Topoisomerase ligand (HY-13704); Blue: Ligands for E3 Ligase and Cereblon ligand (HY-W023573); Black: linker).

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SN38-(PEG)2-Pom-α

SN38-(PEG)2-Pom-α Chemical Structure

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SN38-(PEG)2-Pom-α Related Antibodies

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Description

SN38-(PEG)2-Pom-α is a selective PROTAC RPL15 degrader. SN38-(PEG)2-Pom-α induces ubiquitin-mediated degradation of RPL15 without affecting TOP1. SN38-(PEG)2-Pom-α induces damage-associated molecular pattern (DAMP) secretion from cancer cells, which activated cGAS-STING signaling in dendritic cells. SN38-(PEG)2-Pom-α enhances anti-PD-1 immunotherapy in a murine melanoma tumor model expressing human CRBN. SN38-(PEG)2-Pom-α can be used for melanoma research[1]. (Pink: Topoisomerase ligand (HY-13704); Blue: Ligands for E3 Ligase and Cereblon ligand (HY-W023573); Black: linker).

Molecular Weight

918.90

Formula

C46H46N8O13
SMILES

CCC1=C2C(C=CC(OCC3=CN(CCOCCOCCOCC(NC4=CC(C(N(C5CCC(NC5=O)=O)C6=O)=O)=C6C=C4)=O)N=N3)=C2)=NC7=C1CN(C8=O)C7=CC9=C8COC([C@@]9(CC)O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SN38-(PEG)2-Pom-α Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SN38-(PEG)2-Pom-αPROTACsSTINGStimulator of Interferon GenesTMEM173MITAERISMPYSdamage-associated molecular patterncGAS-STING signalingdendritic cellsmurine melanoma tumor modelInhibitorinhibitorinhibit

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SN38-(PEG)2-Pom-α
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