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Cat. No.: HY-W1063697

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5,8-Dimethoxyquinoxaline

5,8-Dimethoxyquinoxaline is a drug intermediate that can be used in studies related to organic synthesis. The derived cyclization product of 5,8-Dimethoxyquinoxaline specifically blocks TOP1-mediated DNA cleavage reactions.

For research use only. We do not sell to patients.

CAS No.: 19506-19-5
Formula: C₁₀H₁₀N₂O₂
Molecular Weight:190.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

5,8-Dimethoxyquinoxaline Chemical Structure

CAS No.: 19506-19-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

5,8-Dimethoxyquinoxaline serves as the core synthetic precursor of TU100 quinoxaline analogs; all its derivatives inhibit the viability of BT5 breast cancer and PC3 prostate cancer cells^[1].
5,8-Dimethoxyquinoxaline undergoes oxidation and chlorination to yield a dichloro intermediate, which then undergoes cyclization to form indoloquinoxaline derivatives targeting TOP1^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 19506-19-5
Molecular Weight 190.20
Formula C₁₀H₁₀N₂O₂
SMILES

N=1C=CN=C2C1C(OC)=CC=C2OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Oladapo F T. Synthesis of TU100 Analogs and Biological Assays. College of Graduate Studies: Theses & Dissertations, 2025, 2959.

[2]. Shen D Q, et al. Design, Synthesis, and Cytotoxicity of Indolizinoquinoxaline-5,12-dione Derivatives, Novel DNA Topoisomerase IB Inhibitors. Australian Journal of Chemistry, 2010, 63(7): 1116-1121.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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