NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride

Name: NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride
Brand: MedChemExpress
SKU: HY-148819A
Rating: 4.5 (0 reviews)

Art. -Nr.: HY-148819A Reinheit: 98.46%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

NH2-bicyclopentane-7-MAD-MDCPT hydrochloride (Formula I) is a topoisomerase I (TOP1) inhibitor. NH2-bicyclopentane-7-MAD-MDCPT hydrochloride is applicable to the synthesis of the ADC ABBV-969. NH2-bicyclopentane-7-MAD-MDCPT hydrochloride is used in research on lung adenocarcinoma and melanoma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride Chemische Struktur

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
200 mg	Angebot einholen
500 mg	Angebot einholen

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Other Forms of NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride:

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT In-stock

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle ADC Payload Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

Alle Topoisomerase Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Topoisomerase Topo I Topo II DNA gyrase

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

IC₅₀ & Target^[1]

Topoisomerase I

In Vitro

(7S)-14-(3-aminobicyclo[1.1.1]pentan-1-yl)-7-ethyl-7-hydroxy-2H,10H-[1,3]dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione (Example 1G) potently inhibits the viability of Calu-6 human lung adenocarcinoma cells and A375 human malignant melanoma cells with EC₅₀ values of 0.57 nM and 0.50 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

509.94

Formel

C₂₆H₂₄ClN₃O₆

Appearance

Solid

Color

Yellow to brown

SMILES

NC12CC(C2)(C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(OCO8)=C8C=C73)C1.[H]Cl

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 25 mg/mL (49.03 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9610 mL	9.8051 mL	19.6101 mL
5 mM	0.3922 mL	1.9610 mL	3.9220 mL
10 mM	0.1961 mL	0.9805 mL	1.9610 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 98.46%

Select Batch:

Data Sheet (279 KB) SDS (252 KB)

COA (260 KB) HNMR (414 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Andrew C. Phillips, et al. Anti-c-met antibody drug conjugates.WO2022232834.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9610 mL	9.8051 mL	19.6102 mL	49.0254 mL
	5 mM	0.3922 mL	1.9610 mL	3.9220 mL	9.8051 mL
	10 mM	0.1961 mL	0.9805 mL	1.9610 mL	4.9025 mL
	15 mM	0.1307 mL	0.6537 mL	1.3073 mL	3.2684 mL
	20 mM	0.0981 mL	0.4903 mL	0.9805 mL	2.4513 mL
	25 mM	0.0784 mL	0.3922 mL	0.7844 mL	1.9610 mL
	30 mM	0.0654 mL	0.3268 mL	0.6537 mL	1.6342 mL
	40 mM	0.0490 mL	0.2451 mL	0.4903 mL	1.2256 mL