NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride
Based on 1 Customer Validation
NH2-bicyclopentane-7-MAD-MDCPT hydrochloride (Formula I) is a topoisomerase I (TOP1) inhibitor. NH2-bicyclopentane-7-MAD-MDCPT hydrochloride is applicable to the synthesis of the ADC ABBV-969. NH2-bicyclopentane-7-MAD-MDCPT hydrochloride is used in research on lung adenocarcinoma and melanoma.
For research use only. We do not sell to patients.
- Purity : 98.46%
- Formula: C26H24ClN3O6
- Molecular Weight:509.94
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
![NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride Chemical Structure](https://file.medchemexpress.com/product_pic/hy-148819a.gif "Click to View NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride Chemical Structure")
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
![Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT](https://file.medchemexpress.com/product_pic/hy-148820.gif)
All Topoisomerase Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
Topoisomerase I |
In Vitro
(7S)-14-(3-aminobicyclo[1.1.1]pentan-1-yl)-7-ethyl-7-hydroxy-2H,10H-[1,3]dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11(7H,13H)-dione (Example 1G) potently inhibits the viability of Calu-6 human lung adenocarcinoma cells and A375 human malignant melanoma cells with EC50 values of 0.57 nM and 0.50 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 509.94
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Formula C26H24ClN3O6
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Color Yellow to brown
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SMILES
NC12CC(C2)(C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(OCO8)=C8C=C73)C1.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (49.03 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9610 mL | 9.8051 mL | 19.6102 mL | 49.0254 mL |
| 5 mM | 0.3922 mL | 1.9610 mL | 3.9220 mL | 9.8051 mL | |
| 10 mM | 0.1961 mL | 0.9805 mL | 1.9610 mL | 4.9025 mL | |
| 15 mM | 0.1307 mL | 0.6537 mL | 1.3073 mL | 3.2684 mL | |
| 20 mM | 0.0981 mL | 0.4903 mL | 0.9805 mL | 2.4513 mL | |
| 25 mM | 0.0784 mL | 0.3922 mL | 0.7844 mL | 1.9610 mL | |
| 30 mM | 0.0654 mL | 0.3268 mL | 0.6537 mL | 1.6342 mL | |
| 40 mM | 0.0490 mL | 0.2451 mL | 0.4903 mL | 1.2256 mL |
NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride Related Classifications
HY-148819A Related Classifications
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Keywords
- NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT
- ADC Payloads
- Topoisomerase
- malignant melanoma
- female C.B-17 SCID mice
- pancreatic ductal adenocarcinoma
- A375 human malignant melanoma cells
- NCI-H441 NSCLC xenografts
- non-small cell lung cancer
- Hs 746T gastric carcinoma xenografts
- topoisomerase I (TOP1)
- Calu-6 human lung adenocarcinoma cells
- gastric carcinoma
- Inhibitor
- inhibitor
- inhibit