2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Topoisomerase ADC Cytotoxin
  4. NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride 

Cat. No.: HY-148819A Purity: 95.10%
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NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (compound I) hydrochloride is a topoisomerase I inhibitor, which can be delivered to cells through conjugated antibody targeting, and has good ADC activity in vivo and in vitro.

For research use only. We do not sell to patients.

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride Chemical Structure

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride Chemical Structure

Size Price Stock Quantity
1 mg USD 424 In-stock
5 mg USD 975 In-stock
10 mg USD 1561 In-stock
25 mg USD 3278 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride:

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All Topoisomerase Isoform Specific Products:

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Topoisomerase Topo I Topo II

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Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

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Description

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (compound I) hydrochloride is a topoisomerase I inhibitor, which can be delivered to cells through conjugated antibody targeting, and has good ADC activity in vivo and in vitro[1].

Molecular Weight

509.94

Formula

C26H24ClN3O6
Appearance

Solid

Color

Yellow to brown

SMILES

NC12CC(C2)(C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(OCO8)=C8C=C73)C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (196.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9610 mL 9.8051 mL 19.6101 mL
5 mM 0.3922 mL 1.9610 mL 3.9220 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9610 mL 9.8051 mL 19.6102 mL 49.0254 mL
5 mM 0.3922 mL 1.9610 mL 3.9220 mL 9.8051 mL
10 mM 0.1961 mL 0.9805 mL 1.9610 mL 4.9025 mL
15 mM 0.1307 mL 0.6537 mL 1.3073 mL 3.2684 mL
20 mM 0.0981 mL 0.4903 mL 0.9805 mL 2.4513 mL
25 mM 0.0784 mL 0.3922 mL 0.7844 mL 1.9610 mL
30 mM 0.0654 mL 0.3268 mL 0.6537 mL 1.6342 mL
40 mM 0.0490 mL 0.2451 mL 0.4903 mL 1.2256 mL
50 mM 0.0392 mL 0.1961 mL 0.3922 mL 0.9805 mL
60 mM 0.0327 mL 0.1634 mL 0.3268 mL 0.8171 mL
80 mM 0.0245 mL 0.1226 mL 0.2451 mL 0.6128 mL
100 mM 0.0196 mL 0.0981 mL 0.1961 mL 0.4903 mL
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NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPTTopoisomeraseADC CytotoxinADC PayloadInhibitorinhibitorinhibit

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