LRRK2 - leucine rich repeat kinase 2 Gene

Canis lupus familiaris (sub-species: familiaris)

Gene ID: 486608 | Gene type: protein coding

About LRRK2

Primary_assembly 27: 13,454,985-13,594,935 reverse strand.ROS_Cfam_1.0:CM025126.1

This gene has 1 transcript (splice variant), 191 orthologues and 22 paralogues.

LRRK2 Products(1)

mRNA	Protein	Name
XM_038438515.1	XP_038294443.1	leucine-rich repeat serine/threonine-protein kinase 2

LRRK2 Protein Structure

LRR_RI

LRR

LRR_RI

P-loop_NTPase

COR

STKc_LRRK2

0
400
800
1200
1600
2000
2400
2527 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat serine/threonine-protein kinase 2

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112809	GSK2646264	Inhibitor	98.39%	Phase 1

Pre-clinical Phase

Bioactive Molecules (61)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100411	MLi-2	Inhibitor	99.80%	Unkown
HY-13687	IKK 16	Inhibitor	99.88%	Unkown
HY-10875	LRRK2-IN-1	Inhibitor	99.04%	Unkown
HY-148030	XL01126	Inhibitor	98.90%	Unkown
HY-12477	PF-06447475	Inhibitor	99.94%	Unkown
HY-40294	Indazole	Inhibitor	99.83%	Unkown
HY-15796	GNE0877	Inhibitor	99.81%	Unkown
HY-13237	GSK2578215A	Inhibitor	99.82%	Unkown
HY-18163	GNE-7915	Inhibitor	99.82%	Unkown
HY-13687A	IKK 16 hydrochloride	Inhibitor	99.95%	Unkown
HY-13488	HG-10-102-01	Inhibitor	99.55%	Unkown
HY-120085	PFE-360	Inhibitor	99.10%	Unkown
HY-P5979	LRRKtide	Substrate	99.94%	Unkown
HY-12282	GNE-9605	Inhibitor	99.51%	Unkown
HY-15800A	CZC-25146	Inhibitor	99.10%	Unkown
HY-155150	JH-XII-03-02	Inhibitor	99.41%	Unkown
HY-111493	LRRK2 inhibitor 1	Inhibitor	99.80%	Unkown
HY-152107	LRRK2-IN-7	Inhibitor	98.03%	Unkown
HY-156429	MK-1468	Inhibitor	99.69%	Unkown
HY-B0792	CZC-54252	Inhibitor	98.05%	Unkown
HY-142647	EB-42486	Inhibitor	99.62%	Unkown
HY-163064	CC-3240	Degrader	98.23%	Unkown
HY-16936	JH-II-127	Inhibitor	98.0%	Unkown
HY-18163A	GNE-7915 tosylate	Inhibitor	99.06%	Unkown
HY-112855	PF-06454589	Inhibitor	99.91%	Unkown
HY-W107722	IN04		98.51%	Unkown
HY-148353	PF-06455943	Inhibitor	98.21%	Unkown
HY-75368	SRI-31255	Inhibitor	99.88%	Unkown
HY-152107A	(R,R)-LRRK2-IN-7	Inhibitor	/	Unkown
HY-145317	LRRK2-IN-2	Inhibitor	/	Unkown
HY-145318	LRRK2-IN-3	Inhibitor	/	Unkown
HY-175651	LRRK2-IN-20	Inhibitor	/	Unkown
HY-156167	LRRK2-IN-10	Inhibitor	/	Unkown
HY-162699	LY2023-001	Inhibitor	/	Unkown
HY-153058	LRRK2-IN-8	Inhibitor	/	Unkown
HY-174420	RN277	Inhibitor	/	Unkown
HY-158365	LRRK2-IN-14	Inhibitor	/	Unkown
HY-177016	LRRK2-IN-19	Inhibitor	/	Unkown
HY-168041	LRRK2-IN-15	Inhibitor	/	Unkown
HY-171802	PROTAC LRRK2 Degrader-2	Degrader	/	Unkown
HY-151444	LRRK2-IN-6	Inhibitor	/	Unkown
HY-182928	LRRK2-IN-21	Inhibitor	/	Unkown
HY-172952	LRRK2-IN-17	Inhibitor	/	Unkown
HY-178796	PROTAC LRRK2 Degrader-4	Degrader	/	Unkown
HY-171801	PROTAC LRRK2 Degrader-1	Degrader	/	Unkown
HY-151441	LRRK2-IN-5	Inhibitor	/	Unkown
HY-161571	LRRK2-IN-13	Inhibitor	/	Unkown
HY-178797	PROTAC LRRK2 Degrader-3	Degrader	/	Unkown
HY-186110	PROTAC LRRK2 Degrader-5	Degrader	/	Unkown
HY-180320	Lu AF58786	Inhibitor	/	Unkown
HY-165543	SRI-29132	Inhibitor	/	Unkown
HY-134562	PF-06371900	Inhibitor	99.43%	Unkown
HY-169576	LRRK2-IN-16	Inhibitor	/	Unkown
HY-174427	RN341	Inhibitor	/	Unkown
HY-144074	LRRK2-IN-4	Inhibitor	/	Unkown
HY-161570	LRRK2-IN-12	Inhibitor	/	Unkown
HY-B0792A	CZC-54252 hydrochloride	Inhibitor	98.44%	Unkown
HY-153103	LRRK2/NUAK1/TYK2-IN-1	Inhibitor	/	Unkown
HY-P10636	Nictide		/	Unkown
HY-15800	CZC-25146 hydrochloride	Inhibitor	/	Unkown
HY-181046	Multi-kinase-IN-14	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	LRRK2	NCBI	NCBI:120892

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