2. Gene
  3. PF4V1 - platelet factor 4 variant 1 Gene

PF4V1 - platelet factor 4 variant 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1

Gene ID: 5197 | Gene type: protein coding

About PF4V1

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:73,853,296-73,854,483 (from NCBI)

This gene has 1 transcript (splice variant), 25 orthologues and 12 paralogues. Biased expression in bone marrow (RPKM 2.7), spleen (RPKM 1.4) and 9 other tissues.

Summary

The protein encoded by this gene is a chemokine that is highly similar to Platelet Factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015]

PF4V1 Products(1)

mRNA Protein Name
NM_002620.4 NP_002611.1 platelet factor 4 variant precursor

PF4V1 Protein Structure

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (42 - 100)

  • 0
  • 104 a.a.
Protein Preferred Names Protein Names

platelet factor 4 variant

C-X-C motif chemokine 4

Recombinant PF4V1 Proteins

Cat. No. Product Name Accession Purity
HY-P76539 PF4V1 Protein, Human (HEK293, Fc) NP_002611.1 (F31-S104) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10356 PF4V1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PF4V1 MGD MGI:1888711
Macaca mulatta PF4V1 VGNC VGNC:75954
Others PF4V1 NCBI