PF4V1 - platelet factor 4 variant 1 Gene

Also Known as PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5197

About PF4V1

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:73,853,296-73,854,483 (from NCBI)

This gene has 1 transcript (splice variant), 25 orthologues and 12 paralogues. Biased expression in bone marrow (RPKM 2.7), spleen (RPKM 1.4) and 9 other tissues.

Summary

The protein encoded by this gene is a chemokine that is highly similar to Platelet Factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015]

PF4V1 Products (1)

mRNA Protein Name
NM_002620.4 NP_002611.1 platelet factor 4 variant precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28381538 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PF4V1 Protein Structure

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (42 - 100)

  • 0
  • 104 a.a.
Protein Preferred Names Protein Names

platelet factor 4 variant

  • C-X-C motif chemokine 4

PF4V1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PF4V1 P10720 XCL1 Homo sapiens P47992
Filter Binding
28381538
Intra
PF4V1 P10720 CXCL11 Homo sapiens O14625
Filter Binding
28381538
Intra
PF4V1 P10720 CXCL12 Homo sapiens P48061
Filter Binding
28381538
Intra
PF4V1 P10720 CXCL12 Homo sapiens P48061
SPR
28381538
Intra
PF4V1 P10720 CCL25 Homo sapiens O15444
Filter Binding
28381538
Intra
PF4V1 P10720 CCL21 Homo sapiens O00585
Filter Binding
28381538
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PF4V1 Proteins

Cat. No. Product Name Accession Purity
HY-P76539 PF4V1 Protein, Human (HEK293, Fc) NP_002611.1 (F31-S104) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10356 PF4V1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PF4V1 MGD MGI:1888711
Macaca mulatta PF4V1 VGNC VGNC:75954
Others PF4V1 NCBI