UGT1A8 - UDP glucuronosyltransferase family 1 member A8 Gene

Also Known as GNT1; UGT1; UDPGT; UGT1A; UGT1H; UGT-1A; UGT-1H; UGT1.1; UGT1.8; UGT1A1; UGT1-01; UGT1-08; UGT1A8S; hUG-BR1; UDPGT 1-1; UDPGT 1-8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54576

About UGT1A8

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,617,633-233,773,300 (from NCBI)

This gene has 1 transcript (splice variant), 1221 orthologues and 21 paralogues.

Summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as Steroids, bilirubin, Hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including Coumarins, Phenols, Anthraquinones, Flavones, and some opioids. [provided by RefSeq, Jul 2008]

UGT1A8 Products (1)

mRNA	Protein	Name
NM_019076.5	NP_061949.3	UDP-glucuronosyltransferase 1A8 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	17179145	GOA
enables enzyme inhibitor activity	IDA IDA: Inferred from direct assay	19996319	GOA
enables enzyme inhibitor activity	IGI IGI: Inferred from genetic interaction	20610558	GOA
enables fatty acid binding	IDA IDA: Inferred from direct assay	19996319	GOA
enables glucuronosyltransferase activity	IDA IDA: Inferred from direct assay	18052087	GOA
NOT enables glucuronosyltransferase activity	IGI IGI: Inferred from genetic interaction	20610558	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	20610558	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17179145	GOA
enables steroid binding	IDA IDA: Inferred from direct assay	19996319	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular glucuronidation	IDA IDA: Inferred from direct assay	20610558	GOA
involved in fatty acid metabolic process	IDA IDA: Inferred from direct assay	20610558	GOA
involved in flavone metabolic process	IDA IDA: Inferred from direct assay	18052087	GOA
involved in flavonoid glucuronidation	IDA IDA: Inferred from direct assay	20056724	GOA
involved in negative regulation of cellular glucuronidation	IDA IDA: Inferred from direct assay	20610558	GOA
involved in negative regulation of fatty acid metabolic process	IDA IDA: Inferred from direct assay	20610558	GOA
involved in steroid metabolic process	IDA IDA: Inferred from direct assay	15472229	GOA
involved in xenobiotic glucuronidation	IDA IDA: Inferred from direct assay	20056724	GOA
NOT involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	20610558	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	20610558	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17179145	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UGT1A8 Protein Structure

UDPGT

0
100
200
300
400
500
530 a.a.

Protein Preferred Names	Protein Names
UDP-glucuronosyltransferase 1A8	Bilirubin-specific UDPGT isozyme 1

Related Diseases

Diseases	Alias
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Gilbert Syndrome	Gilbert Disease Gilbert'S Disease Gilbert'S Syndrome Cholemia, Familial Familial Nonhemolytic Jaundice Meulengracht Syndrome Gilbert Syndrome, Susceptibility To Hyperbilirubinemia, Gilbert Type Hblrg Hyperbilirubinemia, Arias Type Hyperbilirubinemia I Constitutional Hyperbilirubinemia Gilbert-Meulengracht Syndrome Hereditary Nonhemolytic Jaundice Hyperbilirubinemia Arias Type Hyperbilirubinemia Type 1 Constitutional Liver Dysfunction Gilbert-Lereboullet Syndrome Hyperbilirubinemia 1 Unconjugated Benign Bilirubinemia GILBS Gilberts Syndrome Familial Nonhaemolytic Jaundice Constitutional Hyperbilirubinaemia Hereditary Nonhaemolytic Bilirubinaemia Familial Nonhaemolytic Bilirubinaemia Idiopathic Hyperbilirubinaemia Icterus Intermittens Juvenilis Chronic Intermittent Juvenile Jaundice Low-Grade Chronic Hyperbilirubinaemia Syndrome Benign Unconjugated Bilirubinaemia Syndrome Hereditary Nonhaemolytic Jaundice Idiopathic Unconjugated Hyperbilirubinaemia Gilbert--Lereboullet Syndrome Constitutional Hepatic Dysfunction Meulengracht Icterus Cholaemia Familiaris Simplex Familial Cholaemia Congenital Familial Cholaemia Physiologic Cholaemia Hyperbilirubinaemia Type 1 Gilbert Cholaemia
Crigler-Najjar Syndrome, Type I	Crigler-Najjar Syndrome Crigler-Najjar Syndrome Type 1 Bilirubin Udp Glucuronyl Transferase Deficiency Crigler Najjar Syndrome Crigler Najjar Syndrome, Type 1 Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Bilirubin-Ugt Deficiency Hyperbilirubinemia, Crigler-Najjar Type I Hblrcn1 Familial Nonhemolytic Unconjugated Hyperbilirubinemia Hereditary Unconjugated Hyperbilirubinemia Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1 Bilirubin-Ugt Deficiency Type 1 Crigler-Najjar Syndrome 1 CN1 Cn-I Crigler-Najjar Syndrome Type I Hereditary Unconjugated Hyperbilirubinaemia Ugt Deficiency Bilirubin Glucuronosyltransferase Deficiency Crigler-Najjar Disease Or Syndrome Deficiency Of Glucuronosyltransferase Glucuronyl Transferase Deficiency Glucuronyltransferase Deficiency Udp Glucuronyl Transferase Deficiency Cns - [Crigler-Najjar Syndrome] Congenital Familial Nonhemolytic Jaundice
Bilirubin, Serum Level Of, Quantitative Trait Locus 1	Bilirubin, Serum Level Of, Qtl1 BILIQTL1 Bilirubin, Serum Level Of, Quantitative Trait Locus, Type 1
Hyperbilirubinemia, Transient Familial Neonatal	Lucey-Driscoll Syndrome Transient Familial Neonatal Hyperbilirubinemia HBLRTFN Hyperbilirubinemia, Familial Transient Neonatal Hyperbilirubinemia Transient Familial Neonatal Transient Familial Hyperbilirubinemia
Crigler-Najjar Syndrome, Type Ii	Crigler-Najjar Syndrome Type 2 Hyperbilirubinemia, Crigler-Najjar Type Ii Hblrcn2 Arias Syndrome Crigler Najjar Syndrome Type 2 Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 2 Bilirubin-Ugt Deficiency Type 2 Crigler-Najjar Syndrome 2 CN2 Cn-Ii Crigler-Najjar Syndrome Type Ii Crigler Najjar Syndrome, Type 2
Cholelithiasis
Kernicterus	Bilirubin Encephalopathy Hyperbilirubinemic Encephalopathy Kernicterus Spectrum Disorder
Pigmentation Disease	Pigmentation Disorders Skin Pigmentation Disorder
Epicardium Cancer	Malignant Neoplasm Of Epicardium Epicardial Tumor Malignant Epicardial Tumor Neoplasm Of Epicardium
Neonatal Jaundice	Neonatal Hyperbilirubinemia Neonatal Icterus Jaundice Neonatal Jaundice, Neonatal Hyperbilirubinemia, Neonatal
Dihydropyrimidine Dehydrogenase Deficiency	Dpd Deficiency Familial Pyrimidinemia Hereditary Thymine-Uraciluria Dihydropyrimidinuria Dpyd Deficiency Thymine-Uraciluria, Hereditary Pyrimidinemia, Familial 5-Fluorouracil Toxicity Dihydrouracil Dehydrogenase Deficiency Familial Pyrimidinaemia Thymine-Uracilurea Familial Pyrimidemia Pyrimidinemia Familial DPYDD
Blood Group Incompatibility
Coumarin Resistance	Warfarin Resistance Warfarin Sensitivity Coumadin Sensitivity Warfarin Response Poor Metabolism Of Coumarin Coumarin, Poor Metabolism Of CMRES
Cardiomyopathy, Dilated, With Hypergonadotropic Hypogonadism	Malouf Syndrome Najjar Syndrome Dilated Cardiomyopathy-Hypergonadotropic Hypogonadism Syndrome Cardiogenital Syndrome Genital Anomaly With Cardiomyopathy Cardiomyopathy With Primary Testicular Failure Dilated Cardiomyopathy With Hypergonadotropic Hypogonadism Cardiomyopathy, Congestive, With Hypergonadotropic Hypogonadism Cardiomyopathy, Dilated, With Premature Ovarian Failure Cardiomyopathy Eith Primary Testicular Failure Congestive Cardiomyopathy With Hypergonadotropic Hypogonadism Dilated Cardiomyopathy With Premature Ovarian Failure CMDHH Cardiomyopathy Congestive With Hypergonadotropic Hypogonadism Cardiomyopathy Dilated With Premature Ovarian Failure
Glucosephosphate Dehydrogenase Deficiency	G6pd Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency Deficiency Of Glucose-6-Phosphate Dehydrogenase Glucose 6 Phosphate Dehydrogenase Deficiency Deficiency Of G-6pd G6pdd
Thiopurines, Poor Metabolism Of, 1	Thiopurine S-Methyltransferase Deficiency Tpmt Deficiency Thiopurine Methyltransferase Deficiency Thiopurine S Methyltranferase Deficiency THPM1 Tpmtd Poor Metabolism Of Thiopurines-1 6-Mercaptopurine Sensitivity Thiopurines, Poor Metabolism Of Poor Metabolism Of Thiopurines
Nephrotic Syndrome, Type 20	NPHS20 Nephrotic Syndrome Type 20 Nephrotic Syndrome 20
Hereditary Spherocytosis	Congenital Spherocytic Hemolytic Anemia Spherocytic Anemia Congenital Spherocytosis Spherocytosis, Type 1 Minkowski Chauffard Syndrome Hs Minkowski-Chauffard Disease Minkowski-Chauffard Syndrome Spherocytosis Hereditary Spherocytosis, Hereditary Anemia, Hereditary Spherocytic Hemolytic
Autosomal Dominant Beta Thalassemia	Inclusion Body Beta-Thalassemia
Sickle Cell Anemia	Hemoglobin Sc Disease Anemia, Sickle Cell Hbsc Disease Sickle Cell-Hemoglobin C Disease Syndrome Hb Ss Disease Sickle Cell Trait Drepanocytosis Haemoglobin Sc Disease Hb Sc Disease Hb-S/Hb-C Disease Hb-Ss Disease Without Crisis Hemoglobin S Disease Without Crisis Sickle Cell Anaemia Sickle-Cell/Hb-C Disease Without Crisis Sickle Cell - Hemoglobin C Disease Hbs Disease Hemoglobin S Disease Sickling Disorder Due To Hemoglobin S SKCA Sickle Cell Disease Sickle Cell-Hemoglobin C Disease Sickle-Cell Disease Carrier Sickle-Cell Heterozygous Disorder Haemoglobin A-S Genotype Hb-S - [Sickle Cell Haemoglobin] Carrier Sickle Cell Haemoglobin Trait As - [Sickle Cell Trait] Hbas - [Sickle Cell Haemoglobin Trait] Sickle-Cell Trait Haemoglobin Disease Haemoglobin Sickle Cell Trait Disorder Heterozygous Sickle Cell Trait Hbas - [Heterozygous Haemoglobin S]
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130046	16-Epiestriol	Inhibitor	99.04%	Unkown
HY-135582	Raloxifene 4'-glucuronide	Modulator	98.19%	Unkown
HY-135581	Raloxifene 6-glucuronide	Modulator	96.14%	Unkown
HY-135581S1	Raloxifene 6-glucuronide-d4 lithium	Modulator	/	Unkown
HY-135582S	Raloxifene 4'-glucuronide-d4	Modulator	/	Unkown
HY-135582S1	Raloxifene 4'-glucuronide-d4 lithium	Modulator	/	Unkown
HY-E72110	Human UGT1A8		/	Unkown
HY-N19800	Anhydroicaritin-3,7-di-O-glucuronide		/	Unkown
HY-RS15432	UGT1A8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19083	Ugt1a8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W739842	8-Hydroxywarfarin	Inhibitor	95.0%	Unkown