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GKN1 - gastrokine 1 Gene

Also Known as FOV; CA11; AMP18; BRICD1; foveolin

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56287

About GKN1

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:68,974,636-68,980,976 (from NCBI)

This gene has 3 transcripts (splice variants), 126 orthologues and 2 paralogues. Restricted expression toward stomach (RPKM 11425.3).

Summary

The protein encoded by this gene is found to be down-regulated in human gastric Cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008]

GKN1 Products (1)

mRNA	Protein	Name
NM_019617.4	NP_062563.4	gastrokine-1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	15221938	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GKN1 Protein Structure

BRICHOS

0
100
199 a.a.

Protein Preferred Names	Protein Names
gastrokine-1	18 kDa antrum mucosa protein

GKN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GKN1	Q9NS71	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	32296183
Intra	GKN1	Q9NS71	VAPA	Homo sapiens	Q9P0L0	Validated Y2H	32296183
Intra	GKN1	Q9NS71	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	GKN1	Q9NS71	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	GKN1	Q9NS71	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	GKN1	Q9NS71	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	GKN1	Q9NS71	TREX1	Homo sapiens	Q9NSU2-1	Validated Y2H	32296183
Intra	GKN1	Q9NS71	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	GKN1	Q9NS71	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	GKN1	Q9NS71	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	GKN1	Q9NS71	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	GKN1	Q9NS71	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	GKN1	Q9NS71	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
Intra	GKN1	Q9NS71	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
Intra	GKN1	Q9NS71	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
Intra	GKN1	Q9NS71	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	GKN1	Q9NS71	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	GKN1	Q9NS71	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	GKN1	Q9NS71	UBE2J1	Homo sapiens	Q9Y385	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GKN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76356	Gastrokine 1 Protein, Human (sf9, His)	Q9NS71 (N21-N185)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Granulomatous Disease, Chronic, Autosomal Recessive, 2	Chronic Granulomatous Disease Due To Deficiency Of Ncf-2 CGD2 Ncf2 Deficiency P67-Phox Deficiency Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Ii Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 2 Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Ii Cgd, Autosomal Recessive Cytochrome B-Positive, Type Ii Granulomatous Disease, Chronic, Due To Ncf2 Deficiency Neutrophil Cytosol Factor 2 Deficiency Chronic Granulomatous Disease 2, Autosomal Recessive Autosomal Recessive Chronic Granulomatous Disease 2 Cdg2 Deficiency Of Ncf2 Deficiency Of P67-Phox Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Ii Deficiency Of Neutrophil Cytosol Factor 2 Avellino Corneal Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05461	GKN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19606	Gkn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26102	Gkn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GKN1	VGNC	VGNC:41246
Mus musculus	GKN1	MGD	MGI:1913533
Bos taurus	GKN1	VGNC	VGNC:29388
Felis catus	GKN1	VGNC	VGNC:62570
Rattus norvegicus	GKN1	RGD	RGD:735014
Others	GKN1	NCBI