1. Gene
  2. PSMA3 - proteasome 20S subunit alpha 3 Gene

PSMA3 - proteasome 20S subunit alpha 3 Gene

Homo sapiens

Also known as HC8; PSC3

Gene ID: 5684 | Gene type: protein coding

About PSMA3

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:58,244,843-58,272,004 (from NCBI)

This gene has 13 transcripts (splice variants), 245 orthologues and 18 paralogues. Ubiquitous expression in appendix (RPKM 46.2), lymph node (RPKM 44.1) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PSMA3 Products(2)

mRNA Protein Name
NM_002788.4 NP_002779.1 proteasome subunit alpha type-3 isoform 1
NM_152132.3 NP_687033.1 proteasome subunit alpha type-3 isoform 2

PSMA3 Protein Structure

Proteasome_A_N

Proteasome_A_N: Proteasome subunit A N-terminal signature (8 - 30)

Proteasome

Proteasome: Proteasome subunit (31 - 217)

  • 0
  • 100
  • 200
  • 255 a.a.
Protein Preferred Names Protein Names

proteasome subunit alpha type-3

macropain subunit C8

Recombinant PSMA3 Proteins

Cat. No. Product Name Accession Purity
HY-P75988 PSMA3 Protein, Human (His) P25788-1 (M1-M255) ≥95%

Related Diseases

Diseases Alias
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Familial Cold Autoinflammatory Syndrome 4

FCAS4

Nlrc4-Related Familial Cold Autoinflammatory Syndrome

Nlrc4-Related Familial Cold Urticaria

Autoinflammatory, Cold, Familial, Syndrome, Type 4

Renal Wilms' Tumor

Nonanaplastic Renal Wilm'S Tumor

Nonanaplastic Renal Wilm'S Tumour

Nonanaplastic Renal Wilms Tumor

Renal Wilms' Tumour

Atrophoderma Vermiculata

Atrophoderma Vermiculatum

Folliculitis Ulerythematosa Reticulata

Atrophodermia Vermiculata

Honeycomb Atrophy

Atrophodermia Reticulata Symmetrica Faciei

AVA

Atrophodermia Reticulata

Folliculitis Ulerythematosa

Folliculitis Ulerythematosa Reticulate

Burnett Schwartz Berberian Syndrome

Basal Ganglia Calcification

Fahr'S Syndrome

Fahr'S Disease

Fahr Disease

Basal Ganglia Disease

Basal Ganglia Diseases

Basal Ganglia Disorders

Abnormality Of The Basal Ganglia

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PSMA3 RGD RGD:61844
Mus musculus PSMA3 MGD MGI:104883
Canis familiaris PSMA3 VGNC VGNC:45090
Felis catus PSMA3 VGNC VGNC:69106
Bos taurus PSMA3 VGNC VGNC:33438
Others PSMA3 NCBI