PWWP2B - PWWP domain containing 2B Gene

Also Known as PWWP2; pp8607; bA432J24.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 170394

Summary

Enables NuRD complex binding activity. Predicted to be involved in chromatin remodeling; positive regulation of transcription elongation by RNA polymerase II; and regulation of cold-induced thermogenesis. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in spleen (RPKM 6.8), colon (RPKM 6.1) and 25 other tissues.

PWWP2B Products (2)

mRNA Protein Name
NM_001098637.2 NP_001092107.1 PWWP domain-containing protein 2B isoform 2
NM_138499.4 NP_612508.3 PWWP domain-containing protein 2B isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables NuRD complex binding IDA
IDA: Inferred from direct assay
30228260 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PWWP2B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PWWP2B Q6NUJ5 ABI2 Homo sapiens Q9NYB9-2
Y2H Prey Pooling
32296183
Intra
PWWP2B Q6NUJ5 ABI2 Homo sapiens Q9NYB9-2
Y2H Array
32296183
Intra
PWWP2B Q6NUJ5 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra
PWWP2B Q6NUJ5 PSMA3 Homo sapiens P25788
Validated Y2H
25416956
Intra
PWWP2B Q6NUJ5 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
PWWP2B Q6NUJ5 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11477 PWWP2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown