SDC4 - syndecan 4 Gene

Also Known as SYND4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6385

About SDC4

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,325,288-45,348,424 (from NCBI)

This gene has 1 transcript (splice variant), 197 orthologues, 3 paralogues and is associated with 48 phenotypes. Broad expression in liver (RPKM 189.5), lung (RPKM 100.6) and 23 other tissues.

Summary

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

SDC4 Products (1)

mRNA Protein Name
NM_002999.4 NP_002990.2 syndecan-4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
18093920 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12571249 GOA
enables thrombospondin receptor activity IMP
IMP: Inferred from mutant phenotype
17879962 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
19350579 GOA
involved in positive regulation of exosomal secretion IMP
IMP: Inferred from mutant phenotype
22660413 GOA
involved in positive regulation of extracellular exosome assembly IMP
IMP: Inferred from mutant phenotype
22660413 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SDC4 Protein Structure

Syndecan

Syndecan: Syndecan domain (138 - 196)

  • 0
  • 100
  • 198 a.a.
Protein Preferred Names Protein Names

syndecan-4

  • amphiglycan

SDC4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SDC4 P31431 SDC2 Homo sapiens P34741
Comigration in Gel
18093920
Intra
SDC4 P31431 PRKCA Homo sapiens P17252
Pull Down
12571249
Intra
SDC4 P31431 SDC3 Homo sapiens O75056
Comigration in Gel
18093920
Intra
SDC4 P31431 PMP22 Homo sapiens Q01453
Validated Y2H
32296183
Intra
SDC4 P31431 SGTA Homo sapiens O43765
Y2H Prey Pooling
25416956
Intra
SDC4 P31431 SGTA Homo sapiens O43765
Validated Y2H
25416956
Intra
SDC4 P31431 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra
SDC4 P31431 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra
SDC4 P31431 SGTA Homo sapiens O43765
Y2H Array
25416956
Intra
SDC4 P31431 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
SDC4 P31431 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
SDC4 P31431 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
SDC4 P31431 IL7R Homo sapiens P16871
Y2H Prey Pooling
32296183
Intra
SDC4 P31431 IL7R Homo sapiens P16871
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SDC4 Proteins

Cat. No. Product Name Accession Purity
HY-P71927 Syndecan-4 Protein, Human P31431-1 (E19-E145) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73623 Syndecan-4 Protein, Human (HEK293, His) P31431-1 (E19-E145) ≥ 95%, as determined by reducing SDS-PAGE.

SDC4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87099 Syndecan 4 Antibody (YA6792) WB Human

Related Diseases

Diseases Alias
Thyroid Carcinoma

  • Thyroid Cancer

  • Malignant Neoplasm Of Thyroid

  • Thyroid Neoplasm
Achromatopsia 7

  • ACHM7

  • Achromatopsia, Type 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-159147 SIA​​IS039 99.68% Unkown
HY-RS17074 Sdc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12582 SDC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23518 Sdc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SDC4 VGNC VGNC:98441
Canis familiaris SDC4 VGNC VGNC:45944
Mus musculus SDC4 MGD MGI:1349164
Rattus norvegicus SDC4 RGD RGD:3650
Bos taurus SDC4 VGNC VGNC:34381
Felis catus SDC4 VGNC VGNC:64946
Others SDC4 NCBI