C1QBP - complement C1q binding protein Gene

Also Known as p32; HABP1; gC1qR; GC1QBP; SF2p32; gC1Q-R; COXPD33; SF2AP32

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 708

About C1QBP

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:5,432,777-5,439,155 (from NCBI)

This gene has 7 transcripts (splice variants), 210 orthologues and is associated with 2 phenotypes. Ubiquitous expression in colon (RPKM 56.9), kidney (RPKM 48.1) and 25 other tissues.

Summary

The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum Complement System. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq, Jul 2008]

C1QBP Products (1)

mRNA	Protein	Name
NM_001212.4	NP_001203.1	complement component 1 Q subcomponent-binding protein, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables complement component C1q complex binding	IDA IDA: Inferred from direct assay	8195709	GOA
enables deoxyribonuclease inhibitor activity	IDA IDA: Inferred from direct assay	31353207	GOA
enables enzyme inhibitor activity	IDA IDA: Inferred from direct assay	31353207	GOA
enables hyaluronic acid binding	IDA IDA: Inferred from direct assay	8567680	GOA
enables kininogen binding	IDA IDA: Inferred from direct assay	8662673	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8710908	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	15243141	GOA
enables transcription factor binding	IDA IDA: Inferred from direct assay	15243141	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytosolic ribosome assembly	IMP IMP: Inferred from mutant phenotype	21536856	GOA
involved in negative regulation of MDA-5 signaling pathway	IDA IDA: Inferred from direct assay	19164550	GOA
involved in negative regulation of RIG-I signaling pathway	IDA IDA: Inferred from direct assay	19164550	GOA
involved in negative regulation of defense response to virus	IMP IMP: Inferred from mutant phenotype	19164550	GOA
involved in negative regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	31353207	GOA
involved in negative regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	16177118	GOA
involved in negative regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	10022843	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15243141	GOA
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	17881511	GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	16177118	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15031724	GOA
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	20810993	GOA
involved in positive regulation of dendritic cell chemotaxis	IMP IMP: Inferred from mutant phenotype	16140380	GOA
involved in positive regulation of neutrophil chemotaxis	IDA IDA: Inferred from direct assay	9461517	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	16177118	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	11859136	GOA
involved in positive regulation of trophoblast cell migration	IMP IMP: Inferred from mutant phenotype	20810993	GOA
involved in regulation of complement activation	IDA IDA: Inferred from direct assay	8195709	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	17881511	GOA
located in cytosol	IDA IDA: Inferred from direct assay	15243141	GOA
located in membrane	IDA IDA: Inferred from direct assay	8662673	GOA
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	9305894	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	11083468	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15243141	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1QBP Protein Structure

MAM33

0
100
200
282 a.a.

Protein Preferred Names	Protein Names
complement component 1 Q subcomponent-binding protein, mitochondrial	ASF/SF2-associated protein p32

C1QBP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	C1QBP	Q07021	VTN	Homo sapiens	P04004	Pull Down	8900153
Intra	C1QBP	Q07021	VTN	Homo sapiens	P04004	ELISA	8900153
Intra	C1QBP	Q07021	LBR	Homo sapiens	Q14739	Anti Tag CoIP	28565870
Intra	C1QBP	Q07021	FOXC1	Homo sapiens	Q12948	Anti Tag CoIP	18676636
Intra	C1QBP	Q07021	FOXC1	Homo sapiens	Q12948	Pull Down	18676636
Intra	C1QBP	Q07021	PRKD1	Homo sapiens	Q15139	Anti Bait CoIP	10831594
Intra	C1QBP	Q07021	PRKD1	Homo sapiens	Q15139	Confocal	10831594
Intra	C1QBP	Q07021	PRKD1	Homo sapiens	Q15139	Protein Kinase Assay	10831594
Intra	C1QBP	Q07021	PRKD1	Homo sapiens	Q15139	Pull Down	10831594
Intra	C1QBP	Q07021	PRKD1	Homo sapiens	Q15139	Y2H	10831594
Cross	C1QBP	Q07021	Cdkn2a	Mus musculus	Q64364	Anti Bait CoIP	17486078
Cross	C1QBP	Q07021	Cdkn2a	Mus musculus	Q64364	Anti Tag CoIP	17486078
Cross	C1QBP	Q07021	Cdkn2a	Mus musculus	Q64364	IF	17486078
Intra	C1QBP	Q07021	PRKCZ	Homo sapiens	Q05513	Anti Bait CoIP	10831594
Intra	C1QBP	Q07021	YBX1	Homo sapiens	P67809	Anti Bait CoIP	25497084
Intra	C1QBP	Q07021	YBX1	Homo sapiens	P67809	BN-PAGE	26184334
Intra	C1QBP	Q07021	YBX1	Homo sapiens	P67809	Y2H Pooling	21653829
Intra	C1QBP	Q07021	CDKN2A	Homo sapiens	Q8N726	Pull Down	17486078
Intra	C1QBP	Q07021	CDK13	Homo sapiens	Q14004-2	Anti Bait CoIP	16721827
Intra	C1QBP	Q07021	CDK13	Homo sapiens	Q14004-2	Y2H	16721827
Intra	C1QBP	Q07021	KNG1	Homo sapiens	P01042	Affinity Chrom	8710908
Intra	C1QBP	Q07021	KNG1	Homo sapiens	P01042	Filter Binding	8710908
Intra	C1QBP	Q07021	F12	Homo sapiens	P00748	Filter Binding	8710908
Intra	C1QBP	Q07021	HRK	Homo sapiens	O00198	IF	15031724
Intra	C1QBP	Q07021	HRK	Homo sapiens	O00198	Anti Tag CoIP	15031724
Intra	C1QBP	Q07021	HRK	Homo sapiens	O00198	Pull Down	15031724
Intra	C1QBP	Q07021	APOA1	Homo sapiens	P02647	Anti Tag CoIP	28565870
Intra	C1QBP	Q07021	APOA1	Homo sapiens	P02647	Anti Bait CoIP	28565870
Intra	C1QBP	Q07021	KLF1	Homo sapiens	Q13351	Y2H Prey Pooling	32296183
Intra	C1QBP	Q07021	KLF1	Homo sapiens	Q13351	Validated Y2H	32296183
Intra	C1QBP	Q07021	KLF1	Homo sapiens	Q13351	Y2H Array	32296183
Intra	C1QBP	Q07021	MAVS	Homo sapiens	Q7Z434	Anti Bait CoIP	19164550
Intra	C1QBP	Q07021	MAVS	Homo sapiens	Q7Z434	FRET	19164550
Cross	C1QBP	Q07021	P08563-PRO_0000041302	Rubella virus	P08563-PRO_0000041302	IF	24955142
Cross	C1QBP	Q07021	P08563-PRO_0000041302	Rubella virus	P08563-PRO_0000041302	Pull Down	24955142
Cross	C1QBP	Q07021	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	Y2H	11086025
Cross	C1QBP	Q07021	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	Pull Down	11086025
Cross	C1QBP	Q07021	P07566-PRO_0000041308	Rubella virus	P07566-PRO_0000041308	Y2H	12034482
Cross	C1QBP	Q07021	O40955-PRO_0000240177	Rubella virus	O40955-PRO_0000240177	Pull Down	22238231

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant C1QBP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7692	HABP1/C1QBP Protein, Human (His)	Q07021 (L74-Q282)	≥ 95%, as determined by reducing SDS-PAGE.

C1QBP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82566	GC1q R Antibody (YA2311)	WB, IP	Human, Mouse, Rat
HY-P82566A	GC1q R Antibody (YA2311)(PBS only)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Combined Oxidative Phosphorylation Deficiency 33	COXPD33
Rubella	German Measles Three Day Measles Rubella Nos
Hantavirus Hemorrhagic Fever With Renal Syndrome	Hemorrhagic Fever, Russian Hemorrhagic Nephrosonephritis Hfrs Puumala Virus Nephropathy Hemorrhagic Fever With Renal Syndrome
Cryoglobulinemia	Cryoimmunoglobulinaemia
Korean Hemorrhagic Fever	Hemorrhagic Fever With Renal Syndrome
Angioedema	Angioneurotic Oedema Quincke'S Edema Angioneurotic Edema Giant Urticaria
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Ectodermal Dysplasia 14, Hair/Tooth Type With Or Without Hypohidrosis	ECTD14 Ectodermal Dysplasia 14 Ectn14
Myopathy	Muscular Diseases Myopathies
Hantavirus Pulmonary Syndrome	Hps Four Corners Hantavirus Hards Hantavirus Hantavirus-Associated Respiratory Distress Syndrome Hanta Virus Hantavirus Cardiopulmonary Syndrome Hps - [Hantavirus Pulmonary Syndrome] Hcps - [Hantavirus Cardiopulmonary Syndrome]
Hereditary Angioedema	Hereditary Angioneurotic Edema Hereditary Angioedema Type 1 Hane Angioedema, Hereditary Hae Angioedemas, Hereditary Deficiency Of C1 Esterase Inhibitor C1 Esterase Inhibitor Deficiency C1 Inhibitor Deficiency Familial Angioneurotic Edema Hereditary Bradykinine-Induced Angioedema Hereditary Non Histamine-Induced Angioedema Hae 1 Hae-I Hereditary Angioneurotic Edema Type 1 Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor Hereditary Angioedema Types I And Ii Hereditary Angioneurotic Oedema Familial Angioedema Hae - [Hereditary Angioneurotic Oedema] Bannister Disease, Hereditary Quincke Disease Or Oedema Hereditary Quincke Oedema

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS17652	C1qbp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01720	C1QBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24112	C1qbp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990844	Anti-GC1q R/C1QBP Antibody (60.11)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	C1QBP	RGD	RGD:2230
Felis catus	C1QBP	VGNC	VGNC:98772
Canis familiaris	C1QBP	VGNC	VGNC:38578
Mus musculus	C1QBP	MGD	MGI:1194505
Bos taurus	C1QBP	VGNC	VGNC:26618
Macaca mulatta	C1QBP	VGNC	VGNC:97742
Others	C1QBP	NCBI