Cdkn2a - cyclin dependent kinase inhibitor 2A Gene

Also Known as Arf; p16; MTS1; Pctr1; p19ARF; p16INK4a; p19; ARF-INK4a; INK4a-ARF; Ink4a/Arf; p16(INK4a)

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12578

Summary

Enables MDM2/MDM4 family protein binding activity; enzyme inhibitor activity; and protein N-terminus binding activity. Involved in several processes, including negative regulation of lymphocyte proliferation; positive regulation of apoptotic process; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including negative regulation of cellular protein metabolic process; negative regulation of mammary gland epithelial cell proliferation; and positive regulation of apoptotic process involved in mammary gland involution. Located in cytoplasm and granular component. Part of protein-containing complex. Is expressed in several structures, including bone marrow; central nervous system; dorsal root ganglion; eye; and testis. Human ortholog(s) of this gene implicated in several diseases, including breast Cancer (multiple); carcinoma (multiple); hematologic Cancer (multiple); melanoma (multiple); and nervous system Cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A). [provided by Alliance of Genome Resources, Apr 2022]

Cdkn2a Products (2)

mRNA Protein Name
NM_001040654.1 NP_001035744.1 cyclin-dependent kinase inhibitor 2A p16INK4a
NM_009877.2 NP_034007.1 cyclin-dependent kinase inhibitor 2A p19ARF
Protein Preferred Names Protein Names

cyclin-dependent kinase inhibitor 2A

  • CDK4I

  • alternative reading frame

  • cyclin-dependent kinase 4 inhibitor A

  • cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4)

  • cyclin-dependent kinase inhibitor protein

  • mitochondrial smARF

  • p16-INK4

  • p16-INK4a

Cdkn2a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cdkn2a Q64364 Mta1 Mus musculus Q8K4B0
Anti Bait CoIP
21555589
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119344 MS37452 Inhibitor 99.81% Unkown
HY-138684 MRTX9768 Inhibitor 99.60% Unkown
HY-138684A MRTX9768 hydrochloride Inhibitor 99.88% Unkown
HY-RS02414 CDKN2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16723 Cdkn2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23159 Cdkn2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdkn2a NCBI NCBI:1029