Mta1 - metastasis associated 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 116870

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coactivator activity. Involved in several processes, including circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and locomotor rhythm. Located in cytoplasm and nucleus. Part of NuRD complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and long bone epiphysis. Orthologous to human MTA1 (metastasis associated 1). [provided by Alliance of Genome Resources, Apr 2022]

Mta1 Products (6)

mRNA Protein Name
NM_001346696.1 NP_001333625.1 metastasis-associated protein MTA1 isoform 2
NM_001364620.1 NP_001351549.1 metastasis-associated protein MTA1 isoform 3
NM_001364621.1 NP_001351550.1 metastasis-associated protein MTA1 isoform 4
NM_001364622.1 NP_001351551.1 metastasis-associated protein MTA1 isoform 5
NM_001364623.1 NP_001351552.1 metastasis-associated protein MTA1 isoform 6
NM_054081.2 NP_473422.2 metastasis-associated protein MTA1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
24089055 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11836251 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
24089055 MGI
enables transcription coactivator activity IMP
IMP: Inferred from mutant phenotype
21965678 MGI
Biological Process GO Annotation Evidence References Source
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24089055 MGI
involved in double-strand break repair IMP
IMP: Inferred from mutant phenotype
19805145 MGI
involved in entrainment of circadian clock by photoperiod IMP
IMP: Inferred from mutant phenotype
24089055 MGI
involved in locomotor rhythm IMP
IMP: Inferred from mutant phenotype
24089055 MGI
involved in response to ionizing radiation IDA
IDA: Inferred from direct assay
19805145 MGI
Cellular Component GO Annotation Evidence References Source
part of NuRD complex IPI
IPI: Inferred from physical interaction
16462733 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15978591 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11483358 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metastasis-associated protein MTA1

Mta1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Mta1 Q8K4B0 Six3 Mus musculus Q62233
Anti Bait CoIP
17666527
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08746 MTA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19921 Mta1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26423 Mta1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mta1 NCBI NCBI:9112