Six3 - sine oculis-related homeobox 3 Gene

Also Known as Six3a; Six3b; Six3beta; Six3alpha; E130112M24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20473

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and transcription corepressor binding activity. Involved in several processes, including animal organ development; lens fiber cell apoptotic process; and neuroblast migration. Acts upstream of or within several processes, including animal organ development; circadian behavior; and protein import into nucleus. Located in nucleus. Is expressed in several structures, including embryo ectoderm; limb; maxillary process; nervous system; and sensory organ. Used to study holoprosencephaly 2. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 2. Orthologous to human SIX3 (SIX homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Six3 Products (1)

mRNA Protein Name
NM_011381.4 NP_035511.2 homeobox protein SIX3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12050133 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17066077 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12569128 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17066077 MGI
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
17666527 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12050133 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8814301 MGI
enables transcription corepressor binding IPI
IPI: Inferred from physical interaction
17666527 MGI
Biological Process GO Annotation Evidence References Source
involved in apoptotic process involved in development IMP
IMP: Inferred from mutant phenotype
18694563 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
12569128 MGI
acts upstream of or within camera-type eye development IGI
IGI: Inferred from genetic interaction
12072567 MGI
involved in cell proliferation in forebrain IMP
IMP: Inferred from mutant phenotype
18694563 MGI
acts upstream of or within circadian behavior IMP
IMP: Inferred from mutant phenotype
21525287 MGI
acts upstream of or within diencephalon development IGI
IGI: Inferred from genetic interaction
18094027 MGI
involved in epithelial cell maturation IMP
IMP: Inferred from mutant phenotype
22071110 MGI
acts upstream of or within eye development IDA
IDA: Inferred from direct assay
12050133 MGI
acts upstream of or within forebrain anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
18094027 MGI
acts upstream of or within forebrain anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
18094027 MGI
acts upstream of or within gonad development IGI
IGI: Inferred from genetic interaction
18775421 MGI
involved in lens development in camera-type eye IDA
IDA: Inferred from direct assay
11139622 MGI
involved in lens fiber cell apoptotic process IDA
IDA: Inferred from direct assay
12072567 MGI
involved in lens fiber cell differentiation IDA
IDA: Inferred from direct assay
12072567 MGI
acts upstream of or within lens induction in camera-type eye IMP
IMP: Inferred from mutant phenotype
17066077 MGI
acts upstream of or within multicellular organism growth IGI
IGI: Inferred from genetic interaction
18775421 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12050133 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11139622 MGI
acts upstream of or within negative regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
12569128 MGI
involved in negative regulation of neuron differentiation IDA
IDA: Inferred from direct assay
17576749 MGI
involved in neuroblast differentiation IMP
IMP: Inferred from mutant phenotype
22071110 MGI
involved in neuroblast migration IMP
IMP: Inferred from mutant phenotype
22071110 MGI
involved in optic vesicle morphogenesis IDA
IDA: Inferred from direct assay
11458394 MGI
acts upstream of or within pituitary gland development IGI
IGI: Inferred from genetic interaction
18775421 MGI
involved in pituitary gland development IMP
IMP: Inferred from mutant phenotype
18775421 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17066077 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17066077 MGI
acts upstream of or within protein import into nucleus IDA
IDA: Inferred from direct assay
16024294 MGI
involved in proximal/distal axis specification IDA
IDA: Inferred from direct assay
12163408 MGI
involved in regulation of cell cycle phase transition IDA
IDA: Inferred from direct assay
17576749 MGI
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18775421 MGI
involved in regulation of neural precursor cell proliferation IDA
IDA: Inferred from direct assay
17576749 MGI
involved in regulation of neural retina development IMP
IMP: Inferred from mutant phenotype
20890044 MGI
involved in regulation of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
22071110 MGI
acts upstream of or within telencephalon development IMP
IMP: Inferred from mutant phenotype
18094027 MGI
involved in telencephalon development IMP
IMP: Inferred from mutant phenotype
18694563 MGI
involved in telencephalon regionalization IMP
IMP: Inferred from mutant phenotype
18694563 MGI
acts upstream of or within thyroid gland development IGI
IGI: Inferred from genetic interaction
18775421 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
8814301 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein SIX3

  • sine oculis homeobox homolog 3

  • sine oculis-related homeobox 3 homolog

Six3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Six3 Q62233 Mta1 Mus musculus Q8K4B0
Pull Down
17666527
Intra
Six3 Q62233 Hdac2 Mus musculus P70288
Pull Down
17666527
Intra
Six3 Q62233 Hdac2 Mus musculus P70288
Anti Bait CoIP
17666527
Intra
Six3 Q62233 Tle5 Mus musculus P63002
Y2H
12050133
Cross
Six3 Q62233 gro Drosophila melanogaster P16371
Pull Down
12050133
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12960 SIX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21433 Six3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27951 Six3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Six3 NCBI NCBI:6496