KNG1 - kininogen 1 Gene

Also Known as BK; HK; BDK; KNG; HAE6; HMWK

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3827

About KNG1

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,717,359-186,744,410 (from NCBI)

This gene has 4 transcripts (splice variants), 181 orthologues, 3 paralogues and is associated with 4 phenotypes. Restricted expression toward liver (RPKM 432.8).

Summary

This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with Antibacterial and Antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reduces or depletes angiotensin converting enzyme 2 (ACE2), which results in an increase in levels of des-Arg(9)-bradykinin, a bioactive metabolite of bradykinin that is associated with lung injury and inflammation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2020]

KNG1 Products (3)

mRNA	Protein	Name
NM_000893.4	NP_000884.1	kininogen-1 isoform 2 precursor
NM_001102416.3	NP_001095886.1	kininogen-1 isoform 1 precursor
NM_001166451.2	NP_001159923.1	kininogen-1 isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	3488317	GOA
enables hormone activity	IDA IDA: Inferred from direct assay	1314587	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8710908	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	11290596	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12074933	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	12074933	GOA
involved in negative regulation of blood coagulation	IDA IDA: Inferred from direct assay	11970955	GOA
involved in negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	11970955	GOA
involved in negative regulation of proteolysis	IDA IDA: Inferred from direct assay	3488317	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	16014619	GOA
involved in vasodilation	IDA IDA: Inferred from direct assay	4322742	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	3488317	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KNG1 Protein Structure

Cystatin

0
100
200
300
400
500
600
644 a.a.

Protein Preferred Names	Protein Names
kininogen-1	alpha-2-thiol proteinase inhibitor

KNG1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KNG1	P01042	C1QBP	Homo sapiens	Q07021	Filter Binding	8710908
Intra	KNG1	P01042	C1QBP	Homo sapiens	Q07021	Affinity Chrom	8710908
Cross	KNG1	P01042	Ance	Drosophila melanogaster	Q10714	X-Ray Diffraction	23082758

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KNG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70956	Kininogen-1 Protein, Human (409a.a, HEK293, His)	P01042-2 (Q19-S427)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73266	Kininogen-1 Protein, Human (626a.a, HEK293, His)	NP_001095886.1 (Q19-S644)	≥ 85%, as determined by reducing SDS-PAGE.

KNG1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82395	Kininogen 1 Antibody (YA2140)	WB, IHC-P, IP	Human

Related Diseases

Diseases	Alias
Angioedema, Hereditary, 6	HAE6 Angioedema, Hereditary, Type 6
High Molecular Weight Kininogen Deficiency	HMWK DEFICIENCY Fitzgerald Trait Congenital High-Molecular-Weight Kininogen Deficiency Flaujeac Factor Deficiency Kininogen Deficiency, High Molecular Weight Kininogen Deficiency Hmwk High-Molecular-Weight Kininogen Deficiency, Congenital
Hereditary Angioedema With Normal C1inh Not Related To F12 Or Plg Variant
Angioedema	Angioneurotic Oedema Quincke'S Edema Angioneurotic Edema Giant Urticaria
Brain Edema	Cerebral Edema Intracranial Swelling Wet Brain
Hereditary Angioedema	Hereditary Angioneurotic Edema Hereditary Angioedema Type 1 Hane Angioedema, Hereditary Hae Angioedemas, Hereditary Deficiency Of C1 Esterase Inhibitor C1 Esterase Inhibitor Deficiency C1 Inhibitor Deficiency Familial Angioneurotic Edema Hereditary Bradykinine-Induced Angioedema Hereditary Non Histamine-Induced Angioedema Hae 1 Hae-I Hereditary Angioneurotic Edema Type 1 Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor Hereditary Angioedema Types I And Ii Hereditary Angioneurotic Oedema Familial Angioedema Hae - [Hereditary Angioneurotic Oedema] Bannister Disease, Hereditary Quincke Disease Or Oedema Hereditary Quincke Oedema
Allergic Rhinitis	Hay Fever Allergic Rhinitis, Susceptibility To ALRH Atopic Rhinitis Seasonal Allergic Rhinitis Non-Seasonal Allergic Rhinitis Perenial Allergic Rhinitis Pollenosis Rhinitis Allergic Seasonal Rhinitis, Allergic, Perennial Allergic Rhinitis, Cause Unspecified Pollinosis Pollen Allergy Allergy Nos Due To Pollen Summer Catarrh Other Seasonal Allergic Rhinitis
Impotence	Erectile Dysfunction Sexual Impotence Erectile Dysfunction Adverse Event
C1 Inhibitor Deficiency	Quincke Edema Angioedemas, Hereditary Angioedema
Acquired Angioedema	Acquired C1 Inhibitor Deficiency Angioedema, Acquired Aae Acquired Angioneurotic Edema Acquired Bradykinine-Induced Angioedema Acquired Non Histamine-Induced Angioedema Acquired Angioneurotic Oedema Aae - [Acquired Angioneurotic Oedema]
Angina Pectoris	Prinzmetal'S Variant Angina Angina Prinzmetal Angina Variant Angina Angina Inversa Prinzmetal'S Angina Coronary Artery Vasospasm Angina Pectoris, Variant Variant Angina Pectoris Vasospastic Angina Angor Pectoris Anginal Syndrome Ischaemic Chest Pain Angina Pectoris Syndrome Angina Syndrome Cardiac Angina Syndrome Ap - [Angina Pectoris] Angina Nos Ap - [Angina Pectoris] Syndrome Ischaemic Heart Disease With Angina Heart Angina Chest Angina Angina Attack Anginal Cardiopathy Coronary Pain Nos
Rhinitis	Runny Nose
Congestive Heart Failure	Congestive Heart Disease Heart Failure Cardiac Failure Congestive Chf Weak Heart Heart Failure Congestive Ccf - [Congestive Cardiac Failure] Chf - [Congestive Heart Failure] Congestive Cardiac Diseases Congested Heart Failure Congestive Cardiac Failure Cardiac Anasarca Cardiac Oedema Cardiac Stasis Cardiovascular Oedema Cardiac Hydrops Congestive Failure Heart Congestion Heart Fluid Oedematous Heart
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Renal Hypertension	Hypertension Renal Hypertension, Renal
Ischemia	Acute Coronary Syndrome
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
Retinitis Pigmentosa 87 With Choroidal Involvement	RP87 Retinitis Pigmentosa 87 Retinitis Pigmentosa, Type 87, Choroidal Involvement
Cystitis	Infective Cystitis Urocystitis Pyocystitis
Pulmonary Edema
Alveolar Periostitis	Dry Socket Alveolitis Of Jaw Dry Tooth Socket Alveolar Pyorrhea Alveolar Osteitis Alveolitis Sicca Dolorosa Alveolodental Periostitis
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Myofascial Pain Syndrome	Myofascial Pain Syndromes Myofascial Pain Dysfunction Syndrome Fibromyalgia
Whiplash
Cholera	Vibrio Cholerae Infection Cholera - Vibrio Cholerae Cholera Due To Vibrio Cholerae Vibrio Cholerae Cholera Syndrome Asiatic Cholera Epidemic Cholera
Cholinergic Urticaria
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Angioedema, Hereditary, 3	Angioedema, Hereditary, Type Iii Hereditary Angioedema Type Iii Hereditary Angioedema Type 3 HAE3 Estrogen-Related Hae Estrogen-Sensitive Hae Angioneurotic Edema, Hereditary, With Normal C1 Inhibitor Concentration And Function Hae With Normal C1 Inhibitor Concentration And Function Hereditary Angioedema With Normal C1 Inhibitor Activity F12-Related Hereditary Angioedema With Normal C1inh F12-Related Hae With Normal C1 Inhibitor Hae 3 Hae-Iii Hereditary Angioneurotic Edema Type 3 Inherited Estrogen-Associated Angioedema Inherited Estrogen-Associated Angioneurotic Edema Inherited Estrogen-Dependent Angioedema Inherited Estrogen-Dependent Angioneurotic Edema Angioneurotic Edema Hereditary With Normal C1 Inhibitor Concentration And Function Hereditary Angioedema With Normal C1 Esterase Inhibitor Activity
Rocuronium Allergy	Esmeron Allergy Zemuron Allergy
Pre-Eclampsia	Preeclampsia Gestational Hypertension Hypertension Induced By Pregnancy Pre-Eclamptic Toxaemia Pregnancy Associated Hypertension Proteinuric Hypertension Of Pregnancy Hypertension, Pregnancy-Induced, Susceptibility To Preeclampsia/Eclampsia Pregnancy Toxemia Toxaemia Of Pregnancy Gestational Proteinuric Hypertension Pregnancy-Induced Hypertension Toxemia Of Pregnancy Preeclampsia, Susceptibility To Transient Hypertension Of Pregnancy Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria Gestational Hypertension Nos Mild Proteinuric Hypertension Of Pregnancy Pih - [Pregnancy-Induced Hypertension] Pregnancy-Induced Hypertension Nos Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria Pe - [Pre-Eclampsia] Pre-Eclampsia Nos Pre-Eclamptic Nos Pregnancy Pre-Eclampsia Puerperal Pre-Eclampsia Pre-Eclampsia Toxaemia Toxaemia In Pregnancy Pet - [Pre-Eclamptic Toxaemia] Maternal Toxaemia
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Properdin Deficiency, X-Linked	Properdin Deficiency PFD CFPD Properdin P Factor Deficiency Complement Factor Properdin Deficiency X-Linked Properdin Deficiency Properdin Deficiency, Type I Properdin Deficiency, Type 1 Properdin Deficiency Disease
Renovascular Hypertension	Hypertension, Renovascular Hypertension Renovascular
Allergic Disease	Hypersensitivity Allergic Hypersensitivity Disease Allergic Condition Allergic Reaction Allergic Disposition
Toxic Myocarditis
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Varicose Veins	Varices Varix Venous Ectasia Venous Varices Varicosity
Pyruvate Kinase Deficiency Of Red Cells	Pyruvate Kinase Deficiency Pk Deficiency Pyruvate Kinase Deficiency Of Erythrocyte Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency Pyruvate Kinase Deficiency Of Erythrocytes Pkd PKRD Hereditary Non-Spherocytic Hemolytic Anemia Due To Pyruvate Kinase Deficiency Hnsha Pyruvate Kinase-Deficient Hemolytic Anemia Red Cell Pyruvate Kinase Deficiency Deficiency Of Pyruvate Kinase Anemia, Hemolytic, Congenital Nonspherocytic
Chronic Inducible Urticaria
Pulpitis	Pulp Stones Pulpitis Nos
Complex Regional Pain Syndrome	Complex Regional Pain Syndromes Reflex Sympathetic Dystrophy Crps
Congenital Nonspherocytic Hemolytic Anemia	Hereditary Non-Spherocytic Hemolytic Anemia Hereditary Nonspherocytic Hemolytic Anemia Anemia, Hemolytic, Congenital Nonspherocytic Congenital Nonspherocytic Hemolytic Anaemia Hereditary Nonspherocytic Hemolytic Anaemia Hnsha
Angioedema, Hereditary, 1	Hereditary Angioedema Type I Hereditary Angioneurotic Edema Hane C1 Esterase Inhibitor Deficiency Angioedema, Hereditary, 1 And 2 HAE1 Angioneurotic Edema, Hereditary Angioedema, Hereditary, Type I Hereditary Angioedema Type 2 Hae 2 Hae-Ii Hereditary Angioneurotic Edema Type 2 Angioedema, Hereditary HAE Angioedema, Hereditary, Types I And Ii Hereditary Angioedema, Type Ii Angioedema, Hereditary, Type 1 Angioedemas, Hereditary Hereditary C1 Esterase Inhibitor Deficiency - Dysfunctional Factor Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor Hereditary Angioedema Types I And Ii
Factor Xii Deficiency	Hageman Factor Deficiency Haf Deficiency Factor Xii Deficiency Disease F12 Deficiency Deficiency, Hageman Coagulation Factor 12 Deficiency Factor 12 Deficiency Congenital Factor Xii Deficiency Congenital Hageman Factor Deficiency FA12D Factor Xii Deficiency, Factor Xii
Physical Urticaria	Symptomatic Dermographism
Causalgia	Complex Regional Pain Syndrome, Type Ii Complex Regional Pain Syndrome Type 2
Thiopental Allergy	Penthiobarbital Allergy Pentothiobarbital Allergy
Dermatographia	Dermatographic Urticaria Dermographism Symptomatic Dermographism Urticaria Factitia Factitious Urticaria Dermatographism
Zebrafish Allergy	Danio Rerio Allergy
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Myocardial Stunning
Coronary Artery Vasospasm	Coronary Vasospasm Coronary Artery Spasm
Chronic Spontaneous Urticaria	Chronic Idiopathic Urticaria
Acute Kidney Failure	Acute Renal Failure Acute Kidney Injury Renal Failure Acute Kidney Failure, Acute Pre-Renal Acute Kidney Injury Nontraumatic Acute Kidney Injury Aki - [Acute Kidney Injury] Arf - [Acute Kidney Failure] Acute Kidney Disease Acute Kidney Impairment Acute Ischaemic Renal Failure Acute Hypoxic Kidney Failure Acute Kidney Shutdown Acute Renal Oedema Acute Renal Impairment Acute Kidney Collapse Acute Necrotising Kidney Acute Renal Suppression
Laryngeal Small Cell Carcinoma	Small Cell Carcinoma Of Larynx
Allergic Urticaria
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Pain Agnosia	Analgesia
Complement Deficiency	Complement Deficiency Disease Hereditary Complement Deficiency Diseases
Pleurisy
Epiglottitis	Acute Epiglottitis Acute Epiglottitis And Supraglottitis Acute Epiglottiditis Epiglottiditis Epiglottitis Nos
Vasomotor Rhinitis	Rhinitis, Vasomotor Rhinitis Vasomotor Vmr - [Vasomotor Rhinitis]
Malignant Secondary Hypertension
Pericoronitis	Operculitis
Agnosia	Dyspraxia Primary Visual Agnosia Dyspraxia Syndrome Monomodal Visual Amnesia Visual Amnesia Agnosia, Primary Visual Apraxias Alexia
Trigeminal Nerve Disease	Trigeminal Nerve Diseases Disorders Of 5th Cranial Nerve Disorders Of The Fifth Cranial Nerve
Interstitial Cystitis	Bladder Pain Syndrome Painful Bladder Syndrome Ulcerative Cystitis Ic/Bps Ic/Pbs Interstitial Cystitis/Bladder Pain Syndrome Interstitial Cystitis/Painful Bladder Syndrome Cystitis, Interstitial Chronic Interstitial Cystitis Pelvic Congestion Syndrome Trigonitis
Bursitis	Bursitis, Not Otherwise Specified Inflammation Of Bursa
Carotid Artery Occlusion	Occlusion And Stenosis Of Carotid Artery
Factor Xi Deficiency	Plasma Thromboplastin Antecedent Deficiency Rosenthal Syndrome Pta Deficiency Hemophilia C Rosenthal Factor Deficiency F11 Deficiency Congenital Factor Xi Deficiency Hereditary Factor Xi Deficiency Disease Haemophilia C Factor Xi Deficiency, Autosomal Dominant Rosenthal'S Disease Factor 11 Deficiency Factor Xi Factor Xi Deficiency, Autosomal Recessive Factor Xi Deficiency, Congenital FA11D Thromboplastin Antecedent Deficiency Pta - [Plasma Thromboplastin Antecedent] Deficiency Congenital Factor Xi Deficiency Disease Rosenthal Disease
Somatoform Disorder	Physiological Malfunction Arising From Mental Factor Psychosomatic Disorder Psychophysiologic Disorders
Acute Salpingo-Oophoritis	Acute Salpingitis And Oophoritis
Occlusion Precerebral Artery	Occlusion And Stenosis Of Multiple And Bilateral Precerebral Arteries Occlusion And Stenosis Of Precerebral Artery
Uvulitis	Acute Uvulitis
Perianal Hematoma	External Thrombosed Haemorrhoids Thrombosed External Hemorrhoids
Autonomic Nervous System Disease	Autonomic Nervous System Dysfunction Autonomic Nervous System Disorders Autonomic Nervous System Disorder Autonomic Nervous System Diseases Abnormality Of The Autonomic Nervous System
Oxirane Allergy	Ethylene Oxide Allergy Eto Allergy
Hypertrophy Of Tongue Papillae	Tongue Papillary Hypertrophy Hypertrophy Of Foliate Papillae
Paine Syndrome	Pain Disorder Pain Microcephaly With Spastic Diplegia Pain Syndrome
Retinitis Pigmentosa 46	RP46 Retinitis Pigmentosa, Autosomal Recessive, Idh3b-Related Retinitis Pigmentosa Autosomal Recessive Idh3b-Related Retinitis Pigmentosa, Type 46
Interval Angle-Closure Glaucoma	Intermittent Angle-Closure Glaucoma Angle-Closure Glaucoma, Subacute Prodromal Angle Closure Glaucoma
Integumentary System Disease
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Diabetes Mellitus	Diabetes
Ventricular Fibrillation, Paroxysmal Familial, 1	Paroxysmal Familial Ventricular Fibrillation Ivf Ventricular Fibrillation, Idiopathic Ventricular Fibrillation VF1 Vf Ventricular Fibrillation, Familial, 1 Paroxysmal Ventricular Fibrillation Idiopathic Ventricular Fibrillation Ventricular Fibrillation, Paroxysmal Familial, Type 1 Ventricular Fibrillation, Paroxysmal Familial Familial Paroxysmal Ventricular Fibrillation 1 Susceptibility To Ventricular Fibrillation During Myocardial Infarction Ventricular Fibrillation Adverse Event
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Night Blindness, Congenital Stationary, Type 1h	Congenital Stationary Night Blindness 1h CSNB1H Congenital Stationary Night Blindness Type 1h Night Blindness, Congenital Stationary, 1h
Combined Oxidative Phosphorylation Deficiency 33	COXPD33
Akinetopsia
Phenytoin Allergy	Dilantin Allergy
Endobronchial Lipoma
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Respiratory Disease Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N4067	Isochenodeoxycholic acid	Agonist	99.90%	Unkown
HY-RS17640	Kng1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07411	KNG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24100	Kng1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KNG1	VGNC	VGNC:102765
Canis familiaris	KNG1	VGNC	VGNC:53466
Rattus norvegicus	KNG1	RGD	RGD:2980
Bos taurus	KNG1	VGNC	VGNC:53586
Macaca mulatta	KNG1	VGNC	VGNC:74198
Others	KNG1	NCBI