Cxcl1 - C-X-C motif chemokine ligand 1 Gene

Also Known as Gro1; CINC-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81503

Summary

Enables chemokine activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of ion transport; and response to amphetamine. Located in extracellular space. Biomarker of several diseases, including acute necrotizing pancreatitis; pneumonia (multiple); prostatitis; severe acute respiratory syndrome; and status epilepticus. Orthologous to human CXCL1 (C-X-C motif chemokine ligand 1); CXCL2 (C-X-C motif chemokine ligand 2); and CXCL3 (C-X-C motif chemokine ligand 3). [provided by Alliance of Genome Resources, Apr 2022]

Cxcl1 Products (1)

mRNA Protein Name
NM_030845.2 NP_110472.2 growth-regulated alpha protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chemokine activity IDA
IDA: Inferred from direct assay
10975996 RGD
Biological Process GO Annotation Evidence References Source
involved in neutrophil chemotaxis IDA
IDA: Inferred from direct assay
12709409 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
10975996 RGD
involved in positive regulation of potassium ion transport IDA
IDA: Inferred from direct assay
19476648 RGD
involved in positive regulation of sodium ion transport IDA
IDA: Inferred from direct assay
18816377 RGD
involved in response to amphetamine IEP
IEP: Inferred from expression pattern
19582783 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
20709317 RGD
involved in response to gamma radiation IEP
IEP: Inferred from expression pattern
20185578 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
20728373 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19390478 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
21442011 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth-regulated alpha protein

  • C-X-C motif chemokine 1

  • chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

  • cytokine-induced neutrophil chemoattractant 1

  • gro

  • platelet-derived growth factor-inducible protein KC

Recombinant Cxcl1 Proteins

Cat. No. Product Name Accession Purity
HY-P7189 GRO-alpha/CXCL1 Protein, Rat P14095 (A25-K96) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115644 BMS-470539 dihydrochloride Agonist 99.85% Unkown
HY-12927 SX-517 Antagonist 99.90% Unkown
HY-163475 CXCL-CXCR1/2-IN-1 Inhibitor 99.64% Unkown
HY-176464 GSK2220691 Inhibitor 99.96% Unkown
HY-169859 EP4 receptor antagonist 7 Antagonist 99.9% Unkown
HY-106463 Hexaprofen / Unkown
HY-114366 BC-1485 Inhibitor / Unkown
HY-120544 BAY-386 Antagonist / Unkown
HY-180831 BRD4 D1-IN-3 Inhibitor / Unkown
HY-N2573 Corydalmine Inhibitor 99.74% Unkown
HY-N2573A Corydalmine hydrochloride Inhibitor / Unkown
HY-RS03383 CXCL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174727 Human CXCR2 mRNA / Unkown
HY-RS16613 Cxcl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23048 Cxcl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99127 Anti-Mouse CD54 Antibody (YN1/1.7.4) Inhibitor 95.00% Unkown
HY-P99120 Anti-Mouse CD11a Antibody (FD441.8) Inhibitor 95.00% Unkown
HY-P992045 HZD37-5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cxcl1 NCBI NCBI:2919