CXCL1 - C-X-C motif chemokine ligand 1 Gene
Also Known as FSP; GRO1; GROa; MGSA; NAP-3; SCYB1; MGSA-a
Species: Homo sapiens
About CXCL1
This gene has 2 transcripts (splice variants), 26 orthologues and 12 paralogues. Biased expression in spleen (RPKM 42.1), urinary bladder (RPKM 38.5) and 12 other tissues.
Summary
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]
CXCL1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001511.4 | NP_001502.1 | growth-regulated alpha protein precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in antimicrobial humoral immune response mediated by antimicrobial peptide |
IDA
IDA: Inferred from direct assay
|
12949249 | GOA |
| involved in killing of cells of another organism |
IDA
IDA: Inferred from direct assay
|
12949249 | GOA |
CXCL1 Protein Structure
IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (40 - 100)
- 0
- 100
- 107 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
growth-regulated alpha protein |
|
CXCL1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CXCL1 | P09341 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
CXCL1 | P09341 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
CXCL1 | P09341 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 |
Recombinant CXCL1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7187 | GRO-alpha/CXCL1 Protein, Human | P09341 (A35-N107) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7363 | GRO-alpha/CXCL1 Protein, Human (CHO) | P09341 (A35-N107) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70508 | GRO-alpha/CXCL1 Protein, Human (HEK293, His) | P09341 (A35-N107) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700040AF | Animal-Free GRO-alpha/CXCL1 Protein, Human (His) | P09341 (A35-N107) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700558 | GRO-alpha/CXCL1 Protein, Human (His) | P09341 (A35-N107) | ≥ 95%, as determined by reducing SDS-PAGE. |
CXCL1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P811112 | CXCL1 Antibody | WB, IHC-P | Human, Mouse, Rat |
| HY-P86829 | CXCL1/GRO alpha Antibody (YA6522) | WB | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Meningitis |
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| Bacterial Meningitis |
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| Tonsillitis |
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| Duodenal Ulcer |
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| Adult Respiratory Distress Syndrome |
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| Endometritis |
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| Gastritis |
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| Bacteriuria |
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| Pneumonia |
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| Pustular Psoriasis |
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| Cowpox |
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| Yellow Fever |
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| Keratitis, Hereditary |
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| Cystitis |
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| Melanoma |
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| Ileus |
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| Peritonitis |
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| Acute Cystitis |
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| Complement Component 6 Deficiency |
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| Rheumatoid Arthritis |
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| Craniopharyngioma |
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| Inflammatory Bowel Disease |
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| Uterine Corpus Endometrial Carcinoma |
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| Asthma |
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| Psoriasis |
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| Multiple Sclerosis |
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| Urethral Syndrome |
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| Diarrhea |
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| Peptic Ulcer Disease |
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| Human Immunodeficiency Virus Type 1 |
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| Bacterial Pneumonia |
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| Proteasome-Associated Autoinflammatory Syndrome 1 |
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| Cystic Fibrosis |
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| Colorectal Cancer |
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| Interstitial Lung Disease 2 |
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| Ovarian Cancer |
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| Autoimmune Disease Of Skin And Connective Tissue |
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| Pancreatic Cancer |
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| Prostate Cancer |
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| Immune Deficiency Disease |
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| Colonic Benign Neoplasm |
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| Diabetes Mellitus |
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| Stroke, Ischemic |
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| Skin Disease |
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| Alzheimer Disease, Familial, 1 |
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| Connective Tissue Disease |
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| Nervous System Disease |
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