TNFRSF10D - TNF receptor superfamily member 10d Gene

Also Known as DCR2; CD264; TRUNDD; TRAILR4; TRAIL-R4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8793

About TNFRSF10D

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:23,135,588-23,164,027 (from NCBI)

This gene has 1 transcript (splice variant), 587 orthologues and 21 paralogues. Ubiquitous expression in gall bladder (RPKM 5.6), colon (RPKM 4.7) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce Apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell Apoptosis. [provided by RefSeq, Jul 2008]

TNFRSF10D Products (1)

mRNA	Protein	Name
NM_003840.5	NP_003831.2	tumor necrosis factor receptor superfamily member 10D precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFRSF10D Protein Structure

TNFR_c6

0
100
200
300
386 a.a.

Protein Preferred Names	Protein Names
tumor necrosis factor receptor superfamily member 10D	TNF receptor-related receptor for TRAIL

TNFRSF10D Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNFRSF10D	Q9UBN6	POLL	Homo sapiens	Q9UGP5-2	Validated Y2H	32296183
Intra	TNFRSF10D	Q9UBN6	PITPNC1	Homo sapiens	Q9UKF7-2	Validated Y2H	32296183
Intra	TNFRSF10D	Q9UBN6	MIEF1	Homo sapiens	Q9NQG6	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFRSF10D Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72439	TRAILR4/TNFRSF10D Protein, Human (HEK293, Fc)	Q9UBN6 (A56-H211)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76863	TRAILR4/TNFRSF10D Protein, Human (HEK293, His)	Q9UBN6 (A56-H211)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78221	TRAILR4/TNFRSF10D Protein, Human (Biotinylated, HEK293, His-Avi)	Q9UBN6 (A56-H211)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78531	TRAILR4/TNFRSF10D Protein, Human (HEK293, His-Avi)	Q9UBN6 (A56-H211)	≥ 95%, as determined by Bis-Tris PAGE.

TNFRSF10D Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82843	DcR2 Antibody (YA2588)	WB, IHC-P, ICC/IF	Human
HY-P84855	DcR2 Antibody (YA4552)	WB, ELISA	Human, Monkey
HY-P84855A	DcR2 Antibody (YA4552)(PBS only)	WB, ELISA	Human, Monkey
HY-P84856	DcR2 Antibody (YA4553)	WB, ELISA	Human, Mouse
HY-P84856A	DcR2 Antibody (YA4553)(PBS only)	WB, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
46,Xy Sex Reversal 8	SRXY8 Male Pseudohermaphroditism Due To Deficiency Of Testicular 17,20-Desmolase Tdd 46,Xy Disorder Of Sex Development Due To Testicular 17,20-Desmolase Deficiency 46xy Sex Reversal 8 46xy Sex Reversal 8, Modifier Of Male Pseudohermaphroditism: Deficiency Of Testicular 17,20-Desmolase
Trigonitis	Bladder Trigonitis Pseudomembranous Trigonitis
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Li-Fraumeni Syndrome 1	Lfs1
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14798	TNFRSF10D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TNFRSF10D	MGD	MGI:1341090