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CLDN9 - claudin 9 Gene

Also Known as DFNB116

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9080

About CLDN9

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,012,923-3,014,505 (from NCBI)

This gene has 1 transcript (splice variant), 86 orthologues, 22 paralogues and is associated with 1 phenotype.

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein is one of the entry cofactors for hepatitis C virus. Mouse studies revealed that this gene is required for the preservation of sensory cells in the hearing organ and the gene deficiency is associated with deafness. [provided by RefSeq, Jun 2010]

CLDN9 Products (1)

mRNA	Protein	Name
NM_020982.4	NP_066192.1	claudin-9

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20375010	GOA
enables virus receptor activity	IMP IMP: Inferred from mutant phenotype	20375010	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	20375010	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	31175426	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN9 Protein Structure

PMP22_Claudin

0
100
200
217 a.a.

Protein Preferred Names	Protein Names
claudin-9

CLDN9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CLDN9	O95484	GRM2	Homo sapiens	Q14416	Validated Y2H	32296183
Intra	CLDN9	O95484	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	CLDN9	O95484	ADIPOQ	Homo sapiens	Q15848	Validated Y2H	32296183
Intra	CLDN9	O95484	ERMP1	Homo sapiens	Q7Z2K6	Validated Y2H	32296183
Intra	CLDN9	O95484	PLPP6	Homo sapiens	Q8IY26	Validated Y2H	32296183
Intra	CLDN9	O95484	C4orf3	Homo sapiens	Q8WVX3-2	Validated Y2H	32296183
Intra	CLDN9	O95484	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	CLDN9	O95484	VSTM1	Homo sapiens	Q6UX27-3	Validated Y2H	32296183
Intra	CLDN9	O95484	PLPPR2	Homo sapiens	Q96GM1	Y2H Array	32296183
Intra	CLDN9	O95484	PLPPR2	Homo sapiens	Q96GM1	Y2H Prey Pooling	32296183
Intra	CLDN9	O95484	PLPPR2	Homo sapiens	Q96GM1	Validated Y2H	32296183
Intra	CLDN9	O95484	EXTL1	Homo sapiens	Q92935	Validated Y2H	32296183
Intra	CLDN9	O95484	AMIGO1	Homo sapiens	Q86WK6	Validated Y2H	32296183
Intra	CLDN9	O95484	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	CLDN9	O95484	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	CLDN9	O95484	AOC3	Homo sapiens	Q16853	Validated Y2H	32296183
Intra	CLDN9	O95484	MAL	Homo sapiens	P21145	Validated Y2H	32296183
Intra	CLDN9	O95484	EMP1	Homo sapiens	P54849	Validated Y2H	32296183
Intra	CLDN9	O95484	IGFBP5	Homo sapiens	P24593	Validated Y2H	32296183
Intra	CLDN9	O95484	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	CLDN9	O95484	BNIP3	Homo sapiens	Q12983	Validated Y2H	32296183
Intra	CLDN9	O95484	MALL	Homo sapiens	Q13021	Validated Y2H	32296183
Intra	CLDN9	O95484	CYB561	Homo sapiens	P49447	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLDN9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700407	Claudin-9/CLDN9 Protein-VLP, Human (HEK293, His)	O95484 (M1-V217)	Purity analysis by SDS-PAGE is not available for VLP proteins.

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 116	DFNB116 Deafness, Autosomal Recessive, 116
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus
Sacrum Chordoma
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Deafness, Autosomal Recessive 29	DFNB29 Autosomal Recessive Nonsyndromic Deafness 29 Autosomal Recessive Deafness 29 Deafness, Autosomal Recessive, 29 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 29 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 29 Deafness, Autosomal Recessive, Type 29
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Deafness, Autosomal Recessive 49	DFNB49 Autosomal Recessive Nonsyndromic Deafness 49 Autosomal Recessive Deafness 49 Deafness, Autosomal Recessive, 49 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 49 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 49 Deafness, Autosomal Recessive, Type 49
Deafness, Autosomal Recessive 86	DFNB86 Autosomal Recessive Nonsyndromic Deafness 86 Autosomal Recessive Deafness 86 Deafness, Autosomal Recessive, 86 Deafness, Nonsyndromic, Autosomal Recessive, Type 86
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Autosomal Recessive Nonsyndromic Deafness	Deafness, Autosomal Recessive, Nonsyndromic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02777	CLDN9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20380	Cldn9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26890	Cldn9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992221	Anti-CLDN9 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CLDN9	VGNC	VGNC:27420
Canis familiaris	CLDN9	VGNC	VGNC:39323
Rattus norvegicus	CLDN9	RGD	RGD:1308999
Felis catus	CLDN9	VGNC	VGNC:60939
Mus musculus	CLDN9	MGD	MGI:1913100
Others	CLDN9	NCBI