2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Glisoxepide

Glisoxepide, a sulphonamide derivative, is an orally available nonselective K(ATP) channel blocker, with antihyperglycemic activity and cardiovascular regulation effect.

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Glisoxepide

Glisoxepide 構造式

CAS 番号 : 25046-79-1

容量 価格（税別） 在庫状況
5 mg $425 見積もりとリードタイムを求めるのご確認
10 mg $685 見積もりとリードタイムを求めるのご確認

* アイテムを追加する前、数量をご選択ください

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Glisoxepide 関連抗体

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製品説明

Glisoxepide, a sulphonamide derivative, is an orally available nonselective K(ATP) channel blocker, with antihyperglycemic activity and cardiovascular regulation effect[1][2][3].

IC50 & Target

K(ATP) channel[1]
体外実験

Glisoxepide inhibits the uptake of bile acids into isolated rat hepatocytes[3].
Glisoxepide noncompetitively inhibits the cholate uptake with a Ki of 200 μM[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glisoxepide 関連抗体
分子量

449.52

分子式

C20H27N5O5S
CAS 番号
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(C1=NOC(C)=C1)NCCC2=CC=C(S(=O)(NC(NN3CCCCCC3)=O)=O)C=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 4.5 mg/mL (10.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2246 mL 11.1230 mL 22.2460 mL
5 mM 0.4449 mL 2.2246 mL 4.4492 mL
10 mM 0.2225 mL 1.1123 mL 2.2246 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2246 mL 11.1230 mL 22.2460 mL 55.6149 mL
5 mM 0.4449 mL 2.2246 mL 4.4492 mL 11.1230 mL
10 mM 0.2225 mL 1.1123 mL 2.2246 mL 5.5615 mL
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Glisoxepide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glisoxepide25046-79-1Potassium ChannelKcsAsulphonamidesulfonylureasK(ATP)potassiumchannelantihyperglycemicsulphonylureacardiovascularregulationInhibitorinhibitorinhibit

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製品名:
Glisoxepide
製品番号:
HY-A0176
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