2. GPCR/G Protein
  3. G protein-coupled Bile Acid Receptor 1
  4. GPBAR-A

GPBAR-A is a specific agonist of the bile acid receptor GPBAR1. GPBAR-A can be used for the research of diabetes mellitus.

For research use only. We do not sell to patients.

GPBAR-A Chemical Structure

GPBAR-A Chemical Structure

CAS No. : 877052-79-4

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Based on 1 publication(s) in Google Scholar

GPBAR-A Related Antibodies

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Description

GPBAR-A is a specific agonist of the bile acid receptor GPBAR1. GPBAR-A can be used for the research of diabetes mellitus[1].

In Vitro

GPBAR-A (3 μM; 24-36 h) stimulates the release of glucagon-like peptide (GLP-1) in GLUTag cells[1].
GPBAR-A (3 μM; 24-36 h) increases GLP-1 release 4.2-fold in primary colonic cultures[1].
GPBAR-A (3 μM; 24-36 h) increases GLP-1 release 2.6-fold in upper small intestinal cultures[1].
GPBAR-A (3 μM; 24-36 h) also increases the cAMP concentration in GLUTag cells by 57%[1].
GPBAR-A (3 μM; 24-36 h) increases GLP-1 secretion in the presence of diazoxide (KATP channel opener, 340 μM) and 70 mM KCl[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GPBAR-A Related Antibodies
Molecular Weight

484.37

Formula

C23H15F7N2O2
CAS No.
SMILES

O=C1N(CC2=C(C3=C(F)C=CC=C3)C=CN=C2OC1)CC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GPBAR-A Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPBAR-A877052-79-4G protein-coupled Bile Acid Receptor 1G-protein coupled receptor 19GPCR19TGR5GPBAR1GLP-1GLUTag cellscAMPprimary colonic culturesdiabetes mellitusInhibitorinhibitorinhibit

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HY-107612
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