Propionyl-DL-carnitine chloride
Based on 1 Customer Validation
Propionyl-DL-carnitine chloride is a carnitine derivative. Propionyl-DL-carnitine chloride can be used for the research of inflammation.
For research use only. We do not sell to patients.
- Purity: 98.10%
- CAS No.: 18828-58-5
- Formula: C10H20ClNO4
- Molecular Weight:253.72
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Propionyl-DL-carnitine chloride shows protection to beta-thalassaemic erythrocytes from oxidative stress[1]. Propionyl-DL-carnitine chloride increases production of 14CO2 from [1-14C]pyruvate and increases the rate of formation of acetyl camitine from pyruvate[2]. Propionyl-DL-carnitine chloride allows the endothelial cells to maintain their functionality and regulatory role on vessel activity for a longer time and decreases the formation of oxygen reactive species due to xanthine oxidase activity on hypoxanthine formed by adenine nucleotide catabolism[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult age-matched male C57BL/6 mice[3]
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Dosage:2 mM/kg
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Administration:Oral gavage; 2 mM/kg/day for 4 weeks
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Result:Increased plasma and urine total carnitine concentrations, but showed no effect on the skeletal muscle carnitine content of mice.
Chemical Information
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CAS No. 18828-58-5
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Appearance Solid
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Molecular Weight 253.72
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Formula C10H20ClNO4
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Color White to off-white
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SMILES
CCC(OC(CC(O)=O)C[N+](C)(C)C)=O.[Cl-]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
Methanol : 250 mg/mL (985.34 mM; Need ultrasonic)
DMSO : 100 mg/mL (394.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Palmieri L, et al. Protection of beta-thalassaemic erythrocytes from oxidative stress by propionyl carnitine. Int J Tissue React. 1994;16(3):121-9. [Content Brief]
[2]. Tassani V, et al. Anaplerotic effect of propionyl carnitine in rat heart mitochondria. Biochem Biophys Res Commun. 1994 Mar 15;199(2):949-53. [Content Brief]
[3]. Morand R, et al. Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. Eur J Nutr. 2014 Sep;53(6):1313-25. [Content Brief]
[4]. Bertelli A, et al. Effect of propionyl carnitine on energy charge and adenine nucleotide content of cardiac endothelial cells during hypoxia. Int J Tissue React. 1991;13(1):37-40. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / Methanol | 1 mM | 3.9414 mL | 19.7068 mL | 39.4135 mL | 98.5338 mL |
| 5 mM | 0.7883 mL | 3.9414 mL | 7.8827 mL | 19.7068 mL | |
| 10 mM | 0.3941 mL | 1.9707 mL | 3.9414 mL | 9.8534 mL | |
| 15 mM | 0.2628 mL | 1.3138 mL | 2.6276 mL | 6.5689 mL | |
| 20 mM | 0.1971 mL | 0.9853 mL | 1.9707 mL | 4.9267 mL | |
| 25 mM | 0.1577 mL | 0.7883 mL | 1.5765 mL | 3.9414 mL | |
| 30 mM | 0.1314 mL | 0.6569 mL | 1.3138 mL | 3.2845 mL | |
| 40 mM | 0.0985 mL | 0.4927 mL | 0.9853 mL | 2.4633 mL | |
| 50 mM | 0.0788 mL | 0.3941 mL | 0.7883 mL | 1.9707 mL | |
| 60 mM | 0.0657 mL | 0.3284 mL | 0.6569 mL | 1.6422 mL | |
| 80 mM | 0.0493 mL | 0.2463 mL | 0.4927 mL | 1.2317 mL | |
| 100 mM | 0.0394 mL | 0.1971 mL | 0.3941 mL | 0.9853 mL |
Propionyl-DL-carnitine chloride Related Classifications
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