Anaplerotic effect of propionyl carnitine in rat heart mitochondria

  • Biochem Biophys Res Commun. 1994 Mar 15;199(2):949-53. doi: 10.1006/bbrc.1994.1321.
V Tassani  1 ,  F Cattapan ,  L Magnanimi ,  A Peschechera
Affiliations
  • 1. Dept. of Biological Chemistry, University of Padova, Italy.
PMID: 8135845 DOI: 10.1006/bbrc.1994.1321
Abstract

Carnitine and propionyl carnitine both increase production of 14CO2 from [1-14C]pyruvate but only the latter, in a process inhibited by malonate, increases oxygen uptake and 14CO2 evolution from [2-14C]pyruvate. Carnitine increases the rate of formation of acetyl carnitine from pyruvate to a greater extent than propionyl carnitine. These effects of carnitine and propionyl carnitine are not detectable in mitochondria (e.g., rat liver) deficient in carnitine acetyl transferase activity.

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