2. Metabolic Enzyme/Protease
  3. Phosphorylase
  4. GPi688

GPi688 is a potent and orally active glycogen phosphorylase (GPa) inhibitor with IC50s of 19 nM, 61 nM and 12 nM for human liver GPa, rat liver GPa and human skeletal muscle GPa, respectively. GPi688 can inhibit glucagons-mediated glucose output in rat primary hepatocytes. GPi688 can be used for researching glucagon-mediated hyperglycaemia.

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GPi688

GPi688 화학구조

CAS No. : 918902-32-6

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GPi688 Related Antibodies

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제품 설명

GPi688 is a potent and orally active glycogen phosphorylase (GPa) inhibitor with IC50s of 19 nM, 61 nM and 12 nM for human liver GPa, rat liver GPa and human skeletal muscle GPa, respectively[1]. GPi688 can inhibit glucagons-mediated glucose output in rat primary hepatocytes. GPi688 can be used for researching glucagon-mediated hyperglycaemia[2].

IC50 & Target

IC50: 19 nM (human liver GPa), 61 nM (rat liver GPa), 12 nM (human skeletal muscle GPa)[1]
Cellular Effect
Cell Line Type Value Description References
Hepatocyte IC50
1.1 μM
Compound: 33
Inhibition of glucose output in glucagon challenged primary rat hepatocytes
Inhibition of glucose output in glucagon challenged primary rat hepatocytes
[PMID: 17095214]
분자량

419.88

화학식

C19H18ClN3O4S
CAS No.
SMILES

O=C(C1=CC(C=C(Cl)S2)=C2N1)NC3C(N(C[C@@H](O)CO)C4=C(C=CC=C4)C3)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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GPi688 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPi688918902-32-6GPi 688GPi-688PhosphorylaseHyperglycaemiaGlucagonsHepatocytesGlycogen phosphorylaseInhibitorinhibitorinhibit

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상품명:
GPi688
Cat. No.:
HY-108614
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