HIF-1α-IN-4
Based on 1 Customer Validation
HIF-1α-IN-4 is a HIF-1α inhibitor with an IC50 value of 24 nM (in HEK293T cell). HIF-1α-IN-4 downregulates VEGF and PDK1 mRNA expressions under hypoxia. HIF-1α-IN-4 can be used in the research of cancer.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 2826221-23-0
- Formula: C16H12N2O3
- Molecular Weight:280.28
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
HIF-1α[1]
HIF-1α-IN-4 (compound 31, 24 h) shows inhibitory effects against HIF-1α transcription in HEK293T cells, with an IC50 value of 24 nM[1].
HIF-1α-IN-4 (0-50 μM, 24 h) downregulates VEGF and PDK1 mRNA expressions under hypoxia in HEK293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293T cells under hypoxia
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Concentration:0-50 μM approximately
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Incubation Time:24 h
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Result:Dose-dependently reduces VEGF and PDK1 mRNA expression.
Chemical Information
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CAS No. 2826221-23-0
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Appearance Solid
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Molecular Weight 280.28
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Formula C16H12N2O3
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Color White to off-white
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SMILES
O=C(C1=NOC2=CC=CC=C12)NC3=CC=C(C(C)=O)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 83.33 mg/mL (297.31 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5679 mL | 17.8393 mL | 35.6786 mL | 89.1965 mL |
| 5 mM | 0.7136 mL | 3.5679 mL | 7.1357 mL | 17.8393 mL | |
| 10 mM | 0.3568 mL | 1.7839 mL | 3.5679 mL | 8.9197 mL | |
| 15 mM | 0.2379 mL | 1.1893 mL | 2.3786 mL | 5.9464 mL | |
| 20 mM | 0.1784 mL | 0.8920 mL | 1.7839 mL | 4.4598 mL | |
| 25 mM | 0.1427 mL | 0.7136 mL | 1.4271 mL | 3.5679 mL | |
| 30 mM | 0.1189 mL | 0.5946 mL | 1.1893 mL | 2.9732 mL | |
| 40 mM | 0.0892 mL | 0.4460 mL | 0.8920 mL | 2.2299 mL | |
| 50 mM | 0.0714 mL | 0.3568 mL | 0.7136 mL | 1.7839 mL | |
| 60 mM | 0.0595 mL | 0.2973 mL | 0.5946 mL | 1.4866 mL | |
| 80 mM | 0.0446 mL | 0.2230 mL | 0.4460 mL | 1.1150 mL | |
| 100 mM | 0.0357 mL | 0.1784 mL | 0.3568 mL | 0.8920 mL |
HIF-1α-IN-4 Related Classifications
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