2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. HIF-1α-IN-4

HIF-1α-IN-4 is a HIF-1α inhibitor with an IC50 value of 24 nM (in HEK293T cell). HIF-1α-IN-4 downregulates VEGF and PDK1 mRNA expressions under hypoxia. HIF-1α-IN-4 can be used in the research of cancer.

For research use only. We do not sell to patients.

HIF-1α-IN-4 Chemical Structure

HIF-1α-IN-4 Chemical Structure

CAS No. : 2826221-23-0

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HIF-1α-IN-4 Related Antibodies

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Description

HIF-1α-IN-4 is a HIF-1α inhibitor with an IC50 value of 24 nM (in HEK293T cell). HIF-1α-IN-4 downregulates VEGF and PDK1 mRNA expressions under hypoxia. HIF-1α-IN-4 can be used in the research of cancer[1].

IC50 & Target

HIF-1α[1]
In Vitro

HIF-1α-IN-4 (compound 31, 24 h) shows inhibitory effects against HIF-1α transcription in HEK293T cells, with an IC50 value of 24 nM[1].
HIF-1α-IN-4 (0-50 μM, 24 h) downregulates VEGF and PDK1 mRNA expressions under hypoxia in HEK293T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HIF-1α-IN-4 Related Antibodies

RT-PCR[1]

Cell Line: HEK293T cells under hypoxia
Concentration: 0-50 μM approximately
Incubation Time: 24 h
Result: Dose-dependently reduces VEGF and PDK1 mRNA expression.
Molecular Weight

280.28

Formula

C16H12N2O3
CAS No.
SMILES

O=C(C1=NOC2=CC=CC=C12)NC3=CC=C(C(C)=O)C=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HIF-1α-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIF-1α-IN-42826221-23-0HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHTumorHEK293ThypoxiaVEGFPDK1Inhibitorinhibitorinhibit

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